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ROS1 ROS proto-oncogene 1, receptor tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 6098, updated on 4-Jan-2025

Summary

Official Symbol
ROS1provided by HGNC
Official Full Name
ROS proto-oncogene 1, receptor tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:10261
See related
Ensembl:ENSG00000047936 MIM:165020; AllianceGenome:HGNC:10261
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROS; MCF3; c-ros-1
Summary
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward lung (RPKM 10.3) See more
Orthologs
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Genomic context

See ROS1 in Genome Data Viewer
Location:
6q22.1
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (117287353..117425942, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (118471267..118609847, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (117608516..117747105, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377964 Neighboring gene vestigial like family member 2 Neighboring gene RN7SK pseudogene 18 Neighboring gene RN7SK pseudogene 51 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_88320 Neighboring gene RAP1B pseudogene 3 Neighboring gene RNA, U6 small nuclear 253, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.
EBI GWAS Catalog
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of ROS in umbilical cord blood mononuclear cells and T-cell lines PubMed
Tat tat HIV-1 Tat induces endoplasmic reticulum (ER) stress response proteins CASP12 (Caspase 12), DDIT3 (CHOP), ROS1, ERN-1 (p-IRE1), EIF2AK3 (p-PERK), and ATF6 in human brain microvascular endothelial cells (HBMECs) PubMed
tat Treatment of astrocytes with cell-permeable superoxide dismutase (SOD) leads to a decrease in Tat-induced ROS generation and NF-kappaB activation PubMed
Vpr vpr Administration of recombinant Vpr to human neurons results in a slow but sustained elevation of intracellular calcium, which leads to ROS production and impairs glutamate signaling PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding  
enables GPI-linked ephrin receptor activity  
enables boss receptor activity  
enables brain-derived neurotrophic factor receptor activity  
enables epidermal growth factor receptor activity  
enables fibroblast growth factor receptor activity  
enables hepatocyte growth factor receptor activity  
enables histone H2AXY142 kinase activity  
enables histone H3Y41 kinase activity  
enables insulin receptor activity  
enables insulin-like growth factor receptor activity  
enables macrophage colony-stimulating factor receptor activity  
enables placental growth factor receptor activity  
enables platelet-derived growth factor alpha-receptor activity  
enables platelet-derived growth factor beta-receptor activity  
enables protein binding PubMed 
enables protein phosphatase binding PubMed 
enables protein tyrosine kinase activity PubMed 
enables protein tyrosine kinase collagen receptor activity  
enables stem cell factor receptor activity  
enables transmembrane receptor protein tyrosine kinase activity  
enables transmembrane-ephrin receptor activity  
enables vascular endothelial growth factor receptor activity  
Process Evidence Code Pubs
involved_in Kit signaling pathway  
involved_in brain-derived neurotrophic factor receptor signaling pathway  
involved_in cell differentiation  
involved_in cell surface receptor protein tyrosine kinase signaling pathway  
involved_in chromatin remodeling  
involved_in collagen-activated tyrosine kinase receptor signaling pathway  
involved_in columnar/cuboidal epithelial cell development  
involved_in ephrin receptor signaling pathway  
involved_in epidermal growth factor receptor signaling pathway  
involved_in fibroblast growth factor receptor signaling pathway  
involved_in hepatocyte growth factor receptor signaling pathway  
involved_in insulin receptor signaling pathway  
involved_in insulin-like growth factor receptor signaling pathway  
involved_in macrophage colony-stimulating factor signaling pathway  
involved_in multicellular organism development  
involved_in platelet-derived growth factor receptor-alpha signaling pathway  
involved_in platelet-derived growth factor receptor-beta signaling pathway  
involved_in protein phosphorylation PubMed 
involved_in regulation of ERK1 and ERK2 cascade  
involved_in regulation of TOR signaling  
involved_in regulation of TOR signaling PubMed 
involved_in regulation of cell growth PubMed 
involved_in spermatogenesis  
involved_in vascular endothelial growth factor receptor-1 signaling pathway  
involved_in vascular endothelial growth factor signaling pathway  
Component Evidence Code Pubs
located_in membrane PubMed 
is_active_in plasma membrane  
part_of receptor complex  

General protein information

Preferred Names
proto-oncogene tyrosine-protein kinase ROS
Names
ROS proto-oncogene 1 , receptor tyrosine kinase
c-ros oncogene 1 , receptor tyrosine kinase
proto-oncogene c-Ros-1
transmembrane tyrosine-specific protein kinase
v-ros avian UR2 sarcoma virus oncogene homolog 1
NP_001365820.1
NP_001365831.1
NP_002935.2
XP_006715611.1
XP_011534351.1
XP_011534352.1
XP_011534353.1
XP_011534355.1
XP_011534356.1
XP_011534357.1
XP_011534358.1
XP_011534359.1
XP_011534360.1
XP_016866661.1
XP_016866662.1
XP_047275187.1
XP_047275188.1
XP_054212147.1
XP_054212148.1
XP_054212149.1
XP_054212150.1
XP_054212151.1
XP_054212152.1
XP_054212153.1
XP_054212154.1
XP_054212155.1
XP_054212156.1
XP_054212157.1
XP_054212158.1
XP_054212159.1
XP_054212160.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033929.1 RefSeqGene

    Range
    5001..142489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_997

mRNA and Protein(s)

  1. NM_001378891.1NP_001365820.1  proto-oncogene tyrosine-protein kinase ROS isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL132671, Z98880
    Conserved Domains (2) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05044
    Location:19462212
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
  2. NM_001378902.1NP_001365831.1  proto-oncogene tyrosine-protein kinase ROS isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL132671, Z98880
    Consensus CDS
    CCDS93994.1
    UniProtKB/TrEMBL
    Q5H8Y1
    Related
    ENSP00000357493.3, ENST00000368507.8
  3. NM_002944.3NP_002935.2  proto-oncogene tyrosine-protein kinase ROS isoform 1 precursor

    See identical proteins and their annotated locations for NP_002935.2

    Status: REVIEWED

    Source sequence(s)
    AL132671, Z98880
    Consensus CDS
    CCDS5116.1
    UniProtKB/Swiss-Prot
    P08922, Q15368, Q5TDB5
    Related
    ENSP00000357494.3, ENST00000368508.7
    Conserved Domains (3) summary
    cd00063
    Location:202281
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05044
    Location:19502216
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
    pfam07714
    Location:19452215
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    117287353..117425942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011173.2XP_016866662.1  proto-oncogene tyrosine-protein kinase ROS isoform X6

  2. XM_017011172.2XP_016866661.1  proto-oncogene tyrosine-protein kinase ROS isoform X5

  3. XM_011536051.3XP_011534353.1  proto-oncogene tyrosine-protein kinase ROS isoform X3

    Conserved Domains (3) summary
    cd00063
    Location:202281
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05044
    Location:19512217
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
    pfam07714
    Location:19462216
    Pkinase_Tyr; Protein tyrosine kinase
  4. XM_011536053.3XP_011534355.1  proto-oncogene tyrosine-protein kinase ROS isoform X7

    Conserved Domains (3) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05044
    Location:19022168
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
    pfam07714
    Location:18972167
    Pkinase_Tyr; Protein tyrosine kinase
  5. XM_006715548.5XP_006715611.1  proto-oncogene tyrosine-protein kinase ROS isoform X4

    Conserved Domains (3) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05044
    Location:19452211
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
    pfam07714
    Location:19402210
    Pkinase_Tyr; Protein tyrosine kinase
  6. XM_011536050.3XP_011534352.1  proto-oncogene tyrosine-protein kinase ROS isoform X2

    Conserved Domains (3) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05044
    Location:19592225
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
    pfam07714
    Location:19542224
    Pkinase_Tyr; Protein tyrosine kinase
  7. XM_011536054.3XP_011534356.1  proto-oncogene tyrosine-protein kinase ROS isoform X8

    Conserved Domains (3) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:19552200
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:19602200
    PKc_like; Protein Kinases, catalytic domain
  8. XM_011536049.3XP_011534351.1  proto-oncogene tyrosine-protein kinase ROS isoform X1

    Conserved Domains (2) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05044
    Location:19602226
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
  9. XM_011536055.3XP_011534357.1  proto-oncogene tyrosine-protein kinase ROS isoform X9

    Conserved Domains (1) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  10. XM_011536056.3XP_011534358.1  proto-oncogene tyrosine-protein kinase ROS isoform X10

    Conserved Domains (1) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  11. XM_011536057.4XP_011534359.1  proto-oncogene tyrosine-protein kinase ROS isoform X11

    Conserved Domains (1) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  12. XM_047419232.1XP_047275188.1  proto-oncogene tyrosine-protein kinase ROS isoform X14

  13. XM_047419231.1XP_047275187.1  proto-oncogene tyrosine-protein kinase ROS isoform X13

  14. XM_011536058.3XP_011534360.1  proto-oncogene tyrosine-protein kinase ROS isoform X12

    Conserved Domains (1) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    118471267..118609847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356177.1XP_054212152.1  proto-oncogene tyrosine-protein kinase ROS isoform X6

  2. XM_054356176.1XP_054212151.1  proto-oncogene tyrosine-protein kinase ROS isoform X5

  3. XM_054356174.1XP_054212149.1  proto-oncogene tyrosine-protein kinase ROS isoform X3

  4. XM_054356178.1XP_054212153.1  proto-oncogene tyrosine-protein kinase ROS isoform X7

  5. XM_054356175.1XP_054212150.1  proto-oncogene tyrosine-protein kinase ROS isoform X4

  6. XM_054356173.1XP_054212148.1  proto-oncogene tyrosine-protein kinase ROS isoform X2

  7. XM_054356179.1XP_054212154.1  proto-oncogene tyrosine-protein kinase ROS isoform X8

  8. XM_054356172.1XP_054212147.1  proto-oncogene tyrosine-protein kinase ROS isoform X1

  9. XM_054356180.1XP_054212155.1  proto-oncogene tyrosine-protein kinase ROS isoform X9

  10. XM_054356181.1XP_054212156.1  proto-oncogene tyrosine-protein kinase ROS isoform X10

  11. XM_054356182.1XP_054212157.1  proto-oncogene tyrosine-protein kinase ROS isoform X11

  12. XM_054356185.1XP_054212160.1  proto-oncogene tyrosine-protein kinase ROS isoform X14

  13. XM_054356184.1XP_054212159.1  proto-oncogene tyrosine-protein kinase ROS isoform X13

  14. XM_054356183.1XP_054212158.1  proto-oncogene tyrosine-protein kinase ROS isoform X12

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