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FES FES proto-oncogene, tyrosine kinase [ Canis lupus familiaris (dog) ]

Gene ID: 609483, updated on 5-Mar-2024

Summary

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Official Symbol
FESprovided by VGNC
Official Full Name
FES proto-oncogene, tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:40825
See related
Ensembl:ENSCAFG00845002249
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
19
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 3 NC_051807.1 (53763060..53772711, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 3 NC_006585.4 (55984668..55994302, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 3 NC_049224.1 (53833898..53843534, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 3 NC_049263.1 (53282201..53291832, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 3 NC_049744.1 (53493421..53503070, complement)

Chromosome 3 - NC_051807.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene mannosidase alpha class 2A member 2 Neighboring gene furin, paired basic amino acid cleaving enzyme Neighboring gene uncharacterized LOC119870811

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase Fes/Fps
Names
feline sarcoma oncogene
feline sarcoma protooncogene
XP_038327877.1
XP_038388811.1
XP_038453136.1
XP_038517317.1
XP_851836.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051807.1 Reference ROS_Cfam_1.0

    Range
    53763060..53772711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038661389.1 → XP_038517317.1  tyrosine-protein kinase Fes/Fps

    UniProtKB/TrEMBL
    A0A8C0KTR4, A0A8C0M251, A0A8C0RWB5, A0A8I3MKV4
    Related
    ENSCAFP00845003250.1, ENSCAFT00845004064.1
    Conserved Domains (3) summary
    cd10361
    Location:451 → 535
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:562 → 813
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    cl12013
    Location:7 → 237
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049263.1 Alternate UMICH_Zoey_3.1

    Range
    53282201..53291832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038471949.1 → XP_038327877.1  tyrosine-protein kinase Fes/Fps

    Conserved Domains (3) summary
    cd10361
    Location:451 → 535
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:562 → 813
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    cl12013
    Location:7 → 237
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049744.1 Alternate UNSW_CanFamBas_1.0

    Range
    53493421..53503070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038597208.1 → XP_038453136.1  tyrosine-protein kinase Fes/Fps

    Conserved Domains (3) summary
    cd10361
    Location:451 → 535
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:562 → 813
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    cl12013
    Location:7 → 237
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049224.1 Alternate UU_Cfam_GSD_1.0

    Range
    53833898..53843534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038532883.1 → XP_038388811.1  tyrosine-protein kinase Fes/Fps

    UniProtKB/TrEMBL
    A0A8C0KTR4, A0A8C0M251, A0A8C0RWB5, A0A8I3MKV4
    Conserved Domains (3) summary
    cd10361
    Location:451 → 535
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:562 → 813
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    cl12013
    Location:7 → 237
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006585.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    55984668..55994302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_846743.6 → XP_851836.1  tyrosine-protein kinase Fes/Fps

    UniProtKB/TrEMBL
    A0A8C0KTR4, A0A8C0M251, A0A8C0RWB5, A0A8I3MKV4
    Conserved Domains (3) summary
    cd10361
    Location:451 → 535
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:562 → 813
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    cl12013
    Location:7 → 237
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein
Heading Accession and Version

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