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SHH sonic hedgehog signaling molecule [ Canis lupus familiaris (dog) ]

Gene ID: 608860, updated on 5-Mar-2024

Summary

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Official Symbol
SHHprovided by VGNC
Official Full Name
sonic hedgehog signaling moleculeprovided by VGNC
Primary source
VGNC:VGNC:46147
See related
Ensembl:ENSCAFG00845013237
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
3
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (20382879..20392367, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (19286449..19295913, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (19386812..19396258, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (18753210..18762671, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (19333131..19342583, complement)

Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene canopy FGF signaling regulator 1 Neighboring gene RNA binding motif protein 33 Neighboring gene developmental pluripotency-associated protein 2-like Neighboring gene uncharacterized LOC119869608 Neighboring gene uncharacterized LOC102155425 Neighboring gene uncharacterized LOC119869530

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primates. Dorus S, et al. Hum Mol Genet, 2006 Jul 1. PMID 16687440
  2. Quantitative analysis of mRNA transcripts of Hox, SHH, PTCH, Wnt, and Fzd genes in canine hematopoietic progenitor cells and various in vitro colonies differentiated from the cells. Ide K, et al. J Vet Med Sci, 2009 Jan. PMID 19194078

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables patched binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell fate specification IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intein-mediated protein splicing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein autoprocessing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sonic hedgehog protein
Names
sonic hedgehog homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051820.1 Reference ROS_Cfam_1.0

    Range
    20382879..20392367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038689583.1 → XP_038545511.1  sonic hedgehog protein

    UniProtKB/TrEMBL
    A0A8C0JX79, A0A8C0JXL5, A0A8C0NU16, A0A8I3NQ51
    Related
    ENSCAFP00845018508.1, ENSCAFT00845023574.1
    Conserved Domains (2) summary
    pfam01079
    Location:187 → 447
    Hint; Hint module
    pfam01085
    Location:39 → 184
    HH_signal; Hedgehog amino-terminal signalling domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049276.1 Alternate UMICH_Zoey_3.1

    Range
    18753210..18762671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038497393.1 → XP_038353321.1  sonic hedgehog protein

    Conserved Domains (2) summary
    pfam01079
    Location:187 → 447
    Hint; Hint module
    pfam01085
    Location:39 → 184
    HH_signal; Hedgehog amino-terminal signalling domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

    Range
    19333131..19342583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038623817.1 → XP_038479745.1  sonic hedgehog protein

    Conserved Domains (2) summary
    pfam01079
    Location:187 → 447
    Hint; Hint module
    pfam01085
    Location:39 → 184
    HH_signal; Hedgehog amino-terminal signalling domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

    Range
    19386812..19396258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038559814.1 → XP_038415742.1  sonic hedgehog protein

    UniProtKB/TrEMBL
    A0A8C0JX79, A0A8C0JXL5, A0A8C0NU16, A0A8I3NQ51
    Conserved Domains (2) summary
    pfam01079
    Location:187 → 447
    Hint; Hint module
    pfam01085
    Location:39 → 184
    HH_signal; Hedgehog amino-terminal signalling domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    19286449..19295913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_845357.5 → XP_850450.1  sonic hedgehog protein

    UniProtKB/TrEMBL
    A0A8C0JX79, A0A8C0JXL5, A0A8C0NU16, A0A8I3NQ51
    Conserved Domains (2) summary
    pfam01079
    Location:187 → 447
    Hint; Hint module
    pfam01085
    Location:39 → 184
    HH_signal; Hedgehog amino-terminal signalling domain
Nucleotide Protein Strain
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