U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

VAV2 vav guanine nucleotide exchange factor 2 [ Canis lupus familiaris (dog) ]

Gene ID: 608060, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
VAV2provided by VGNC
Official Full Name
vav guanine nucleotide exchange factor 2provided by VGNC
Primary source
VGNC:VGNC:58344
See related
Ensembl:ENSCAFG00845011337
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 9
Exon count:
31
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (50977087..51137042, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (49384008..49543991, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (50158900..50319194, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (49738436..49898214, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (50081036..50241047, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097472 Neighboring gene dopamine beta-hydroxylase Neighboring gene sarcosine dehydrogenase Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102156402 Neighboring gene BRD3 opposite strand

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
guanine nucleotide exchange factor VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2
Names
vav 2 oncogene

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    50977087..51137042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038678070.1 → XP_038533998.1  guanine nucleotide exchange factor VAV2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PQL6, A0A8I3NE35, A0A8I3NEZ8
    Related
    ENSCAFP00845015773.1, ENSCAFT00845020123.1
    Conserved Domains (7) summary
    cd10406
    Location:667 → 769
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:819 → 876
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:590 → 649
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:202 → 375
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:389 → 516
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2 → 120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:519 → 576
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  2. XM_038678073.1 → XP_038534001.1  guanine nucleotide exchange factor VAV2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0JJV1, A0A8I3NG32, A0A8P0TF08
    Related
    ENSCAFP00845016338.1, ENSCAFT00845020817.1
    Conserved Domains (7) summary
    cd10406
    Location:657 → 759
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:780 → 837
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:580 → 639
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:197 → 370
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:384 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2 → 120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:509 → 566
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  3. XM_038678072.1 → XP_038534000.1  guanine nucleotide exchange factor VAV2 isoform X3

    UniProtKB/TrEMBL
    A0A8I3NE35, A0A8P0NKU4
    Conserved Domains (7) summary
    cd10406
    Location:657 → 759
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:809 → 866
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:580 → 639
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:197 → 370
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:384 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2 → 120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:509 → 566
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  4. XM_038678071.1 → XP_038533999.1  guanine nucleotide exchange factor VAV2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LR72
    Conserved Domains (7) summary
    cd10406
    Location:663 → 765
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:815 → 872
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:586 → 645
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:198 → 371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:385 → 512
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd20868
    Location:515 → 572
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein
    cl00030
    Location:67 → 121
    CH_SF; calponin homology (CH) domain superfamily

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    49738436..49898214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038486999.1 → XP_038342927.1  guanine nucleotide exchange factor VAV2 isoform X1

    Conserved Domains (7) summary
    cd10406
    Location:667 → 769
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:819 → 876
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:590 → 649
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:202 → 375
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:389 → 516
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2 → 120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:519 → 576
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  2. XM_038487002.1 → XP_038342930.1  guanine nucleotide exchange factor VAV2 isoform X4

    Conserved Domains (7) summary
    cd10406
    Location:657 → 759
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:780 → 837
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:580 → 639
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:197 → 370
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:384 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2 → 120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:509 → 566
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  3. XM_038487001.1 → XP_038342929.1  guanine nucleotide exchange factor VAV2 isoform X3

    Conserved Domains (7) summary
    cd10406
    Location:657 → 759
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:809 → 866
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:580 → 639
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:197 → 370
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:384 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2 → 120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:509 → 566
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  4. XM_038487000.1 → XP_038342928.1  guanine nucleotide exchange factor VAV2 isoform X2

    Conserved Domains (7) summary
    cd10406
    Location:663 → 765
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:815 → 872
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:586 → 645
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:198 → 371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:385 → 512
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd20868
    Location:515 → 572
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein
    cl00030
    Location:67 → 121
    CH_SF; calponin homology (CH) domain superfamily

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    50081036..50241047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038612775.1 → XP_038468703.1  guanine nucleotide exchange factor VAV2 isoform X1

    Conserved Domains (7) summary
    cd10406
    Location:667 → 769
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:819 → 876
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:590 → 649
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:202 → 375
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:389 → 516
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2 → 120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:519 → 576
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  2. XM_038612778.1 → XP_038468706.1  guanine nucleotide exchange factor VAV2 isoform X4

    Conserved Domains (7) summary
    cd10406
    Location:657 → 759
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:780 → 837
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:580 → 639
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:197 → 370
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:384 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2 → 120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:509 → 566
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  3. XM_038612777.1 → XP_038468705.1  guanine nucleotide exchange factor VAV2 isoform X3

    Conserved Domains (7) summary
    cd10406
    Location:657 → 759
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:809 → 866
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:580 → 639
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:197 → 370
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:384 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2 → 120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:509 → 566
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  4. XM_038612776.1 → XP_038468704.1  guanine nucleotide exchange factor VAV2 isoform X2

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    50158900..50319194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038548841.1 → XP_038404769.1  LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PQL6, A0A8I3NE35, A0A8I3NEZ8
    Conserved Domains (7) summary
    cd10406
    Location:667 → 769
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:819 → 876
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:590 → 649
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:202 → 375
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:389 → 516
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2 → 120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:519 → 576
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    49384008..49543991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038615522.1 → XP_038471450.1  guanine nucleotide exchange factor VAV2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PQL6, A0A8I3NE35, A0A8I3NEZ8
    Conserved Domains (7) summary
    cd10406
    Location:667 → 769
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:819 → 876
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:590 → 649
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:202 → 375
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:389 → 516
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2 → 120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:519 → 576
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  2. XM_038615531.1 → XP_038471459.1  guanine nucleotide exchange factor VAV2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0JJV1, A0A8I3NG32, A0A8P0TF08
    Conserved Domains (7) summary
    cd10406
    Location:657 → 759
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:780 → 837
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:580 → 639
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:197 → 370
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:384 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2 → 120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:509 → 566
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  3. XM_038615530.1 → XP_038471458.1  guanine nucleotide exchange factor VAV2 isoform X3

    UniProtKB/TrEMBL
    A0A8I3NE35, A0A8P0NKU4
    Conserved Domains (7) summary
    cd10406
    Location:657 → 759
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:809 → 866
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:580 → 639
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:197 → 370
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:384 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2 → 120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:509 → 566
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  4. XM_038615524.1 → XP_038471452.1  guanine nucleotide exchange factor VAV2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LR72
    Conserved Domains (7) summary
    cd10406
    Location:663 → 765
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:815 → 872
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:586 → 645
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:198 → 371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:385 → 512
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd20868
    Location:515 → 572
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein
    cl00030
    Location:67 → 121
    CH_SF; calponin homology (CH) domain superfamily
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous