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PAK1 p21 (RAC1) activated kinase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 607885, updated on 5-Mar-2024

Summary

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Official Symbol
PAK1provided by VGNC
Official Full Name
p21 (RAC1) activated kinase 1provided by VGNC
Primary source
VGNC:VGNC:52285
See related
Ensembl:ENSCAFG00845009162
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (21465428..21609203)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (21157810..21301590)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (21380679..21525504)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (21241163..21385037)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (21457239..21600991)

Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene chloride nucleotide-sensitive channel 1A Neighboring gene uncharacterized LOC111091522 Neighboring gene aquaporin 11 Neighboring gene 40S ribosomal protein S10-like Neighboring gene ribosomal protein L23a pseudogene Neighboring gene nucleophosmin-like Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene myosin VIIA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pak1 regulates the orientation of apical polarization and lumen formation by distinct pathways. deLeon O, et al. PLoS One, 2012. PMID 22815903, Free PMC Article
  2. Cadherins and Pak1 control contact inhibition of proliferation by Pak1-betaPIX-GIT complex-dependent regulation of cell-matrix signaling. Liu F, et al. Mol Cell Biol, 2010 Apr. PMID 20154149, Free PMC Article
  3. Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine. Tang DD, et al. Biochem J, 2005 Jun 15. PMID 15766329, Free PMC Article
  4. Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation. Whalley HJ, et al. Nat Commun, 2015 Jun 16. PMID 26078008, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pak1 and Pak2 counteract centrosome separation in a kinase-dependent manner.
    Title: Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation.
  2. Pak1 regulates the orientation of apical polarization and lumen formation by distinct pathways
    Title: Pak1 regulates the orientation of apical polarization and lumen formation by distinct pathways.
  3. Data suggest that cadherins are involved in regulation of contact inhibition by controlling the function of the Pak1-betaPIX-GIT complex at focal contacts.
    Title: Cadherins and Pak1 control contact inhibition of proliferation by Pak1-betaPIX-GIT complex-dependent regulation of cell-matrix signaling.
  4. results suggest that the PAK1-mediated site-specific phosphorylation of vimentin may play a role in regulating the reorganization of vimentin intermediate filaments during stimulation of smooth muscle cells with 5-HT
    Title: Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase PAK 1
Names
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
XP_022263333.2
XP_038285916.1
XP_038285917.1
XP_038285918.1
XP_038312241.1
XP_038312242.1
XP_038361297.1
XP_038361298.1
XP_038361299.1
XP_038424447.1
XP_038424448.1
XP_038424449.1
XP_038488604.1
XP_038488605.1
XP_038488606.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051825.1 Reference ROS_Cfam_1.0

    Range
    21465428..21609203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038429989.1 → XP_038285917.1  serine/threonine-protein kinase PAK 1

    UniProtKB/TrEMBL
    A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
    Related
    ENSCAFP00845012600.1, ENSCAFT00845016197.1
    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  2. XM_038429990.1 → XP_038285918.1  serine/threonine-protein kinase PAK 1

    UniProtKB/TrEMBL
    A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
    Related
    ENSCAFP00845012560.1, ENSCAFT00845016147.1
    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  3. XM_038429988.1 → XP_038285916.1  serine/threonine-protein kinase PAK 1

    UniProtKB/TrEMBL
    A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
    Related
    ENSCAFP00845012633.1, ENSCAFT00845016239.1
    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049281.1 Alternate UMICH_Zoey_3.1

    Range
    21241163..21385037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038505370.1 → XP_038361298.1  serine/threonine-protein kinase PAK 1

    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  2. XM_038505371.1 → XP_038361299.1  serine/threonine-protein kinase PAK 1

    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  3. XM_038505369.1 → XP_038361297.1  serine/threonine-protein kinase PAK 1

    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

    Range
    21457239..21600991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038632677.1 → XP_038488605.1  serine/threonine-protein kinase PAK 1

    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  2. XM_038632678.1 → XP_038488606.1  serine/threonine-protein kinase PAK 1

    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  3. XM_038632676.1 → XP_038488604.1  serine/threonine-protein kinase PAK 1

    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

    Range
    21380679..21525504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038568521.1 → XP_038424449.1  serine/threonine-protein kinase PAK 1

    UniProtKB/TrEMBL
    A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  2. XM_038568520.1 → XP_038424448.1  serine/threonine-protein kinase PAK 1

    UniProtKB/TrEMBL
    A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  3. XM_038568519.1 → XP_038424447.1  serine/threonine-protein kinase PAK 1

    UniProtKB/TrEMBL
    A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    21157810..21301590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038456313.1 → XP_038312241.1  serine/threonine-protein kinase PAK 1

    UniProtKB/TrEMBL
    A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  2. XM_038456314.1 → XP_038312242.1  serine/threonine-protein kinase PAK 1

    UniProtKB/TrEMBL
    A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  3. XM_022407625.2 → XP_022263333.2  serine/threonine-protein kinase PAK 1

    UniProtKB/TrEMBL
    A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
    Conserved Domains (2) summary
    cd06654
    Location:248 → 543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain
Nucleotide Protein
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