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HDAC4 histone deacetylase 4 [ Canis lupus familiaris (dog) ]

Gene ID: 607662, updated on 5-Mar-2024

Summary

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Official Symbol
HDAC4provided by VGNC
Official Full Name
histone deacetylase 4provided by VGNC
Primary source
VGNC:VGNC:50629
See related
Ensembl:ENSCAFG00845030282
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 25
Exon count:
31
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 25 NC_051829.1 (49702537..49976665, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 25 NC_006607.4 (49810705..50083929, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 25 NC_049246.1 (49597454..49869914, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 25 NC_049285.1 (49576470..49848695, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 25 NC_049766.1 (49364978..49638565, complement)

Chromosome 25 - NC_051829.1Genomic Context describing neighboring genes Neighboring gene twist family bHLH transcription factor 2 Neighboring gene uncharacterized LOC119865867 Neighboring gene uncharacterized LOC111092423 Neighboring gene reactive oxygen species modulator 1 pseudogene Neighboring gene uncharacterized LOC119865868

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of histone deacetylase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone deacetylase 4
XP_038291885.1
XP_038291886.1
XP_038291887.1
XP_038291888.1
XP_038291889.1
XP_038291890.1
XP_038291891.1
XP_038291892.1
XP_038314124.1
XP_038314125.1
XP_038314126.1
XP_038314127.1
XP_038314128.1
XP_038314129.1
XP_038314130.1
XP_038314131.1
XP_038366807.1
XP_038366808.1
XP_038366809.1
XP_038366810.1
XP_038366811.1
XP_038366812.1
XP_038366813.1
XP_038366814.1
XP_038430304.1
XP_038430305.1
XP_038430306.1
XP_038430307.1
XP_038430308.1
XP_038430310.1
XP_038430311.1
XP_038430312.1
XP_038494539.1
XP_038494540.1
XP_038494541.1
XP_038494542.1
XP_038494543.1
XP_038494544.1
XP_038494545.1
XP_038494546.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051829.1 Reference ROS_Cfam_1.0

    Range
    49702537..49976665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038435961.1 → XP_038291889.1  histone deacetylase 4 isoform X5

    UniProtKB/TrEMBL
    A0A8I3Q401, A0A8P0TJ56
    Related
    ENSCAFP00845042244.1, ENSCAFT00845053756.1
    Conserved Domains (2) summary
    cd10162
    Location:88 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:648 → 1051
    HDAC4; Histone deacetylase 4

  2. XM_038435960.1 → XP_038291888.1  histone deacetylase 4 isoform X4

    UniProtKB/TrEMBL
    A0A8I3Q401, A0A8P0TJ56
    Related
    ENSCAFP00845042225.1, ENSCAFT00845053735.1
    Conserved Domains (2) summary
    cd10162
    Location:88 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:648 → 1056
    HDAC4; Histone deacetylase 4

  3. XM_038435962.1 → XP_038291890.1  histone deacetylase 4 isoform X6

    UniProtKB/TrEMBL
    A0A8I3Q401, A0A8P0TJ56
    Conserved Domains (2) summary
    cd10162
    Location:83 → 147
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:643 → 1051
    HDAC4; Histone deacetylase 4

  4. XM_038435963.1 → XP_038291891.1  histone deacetylase 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C0TIE4
    Conserved Domains (2) summary
    cd10162
    Location:61 → 125
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:621 → 1029
    HDAC4; Histone deacetylase 4

  5. XM_038435958.1 → XP_038291886.1  histone deacetylase 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0TIE4
    Conserved Domains (2) summary
    cd10162
    Location:95 → 159
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:653 → 1061
    HDAC4; Histone deacetylase 4

  6. XM_038435959.1 → XP_038291887.1  histone deacetylase 4 isoform X3

    UniProtKB/TrEMBL
    A0A8C0TIE4
    Conserved Domains (2) summary
    cd10162
    Location:95 → 159
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:655 → 1058
    HDAC4; Histone deacetylase 4

  7. XM_038435957.1 → XP_038291885.1  histone deacetylase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0TIE4
    Conserved Domains (2) summary
    cd10162
    Location:95 → 159
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:655 → 1063
    HDAC4; Histone deacetylase 4

  8. XM_038435964.1 → XP_038291892.1  histone deacetylase 4 isoform X8

    UniProtKB/TrEMBL
    A0A8C0TIE4
    Conserved Domains (2) summary
    cd10162
    Location:40 → 104
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:600 → 1008
    HDAC4; Histone deacetylase 4

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049285.1 Alternate UMICH_Zoey_3.1

    Range
    49576470..49848695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038510883.1 → XP_038366811.1  histone deacetylase 4 isoform X5

    Conserved Domains (2) summary
    cd10162
    Location:88 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:648 → 1051
    HDAC4; Histone deacetylase 4

  2. XM_038510882.1 → XP_038366810.1  histone deacetylase 4 isoform X4

    Conserved Domains (2) summary
    cd10162
    Location:88 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:648 → 1056
    HDAC4; Histone deacetylase 4

  3. XM_038510884.1 → XP_038366812.1  histone deacetylase 4 isoform X6

    Conserved Domains (2) summary
    cd10162
    Location:83 → 147
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:643 → 1051
    HDAC4; Histone deacetylase 4

  4. XM_038510885.1 → XP_038366813.1  histone deacetylase 4 isoform X7

    Conserved Domains (2) summary
    cd10162
    Location:61 → 125
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:621 → 1029
    HDAC4; Histone deacetylase 4

  5. XM_038510880.1 → XP_038366808.1  histone deacetylase 4 isoform X2

    Conserved Domains (2) summary
    cd10162
    Location:95 → 159
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:653 → 1061
    HDAC4; Histone deacetylase 4

  6. XM_038510881.1 → XP_038366809.1  histone deacetylase 4 isoform X3

    Conserved Domains (2) summary
    cd10162
    Location:95 → 159
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:655 → 1058
    HDAC4; Histone deacetylase 4

  7. XM_038510879.1 → XP_038366807.1  histone deacetylase 4 isoform X1

    Conserved Domains (2) summary
    cd10162
    Location:95 → 159
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:655 → 1063
    HDAC4; Histone deacetylase 4

  8. XM_038510886.1 → XP_038366814.1  histone deacetylase 4 isoform X8

    Conserved Domains (2) summary
    cd10162
    Location:40 → 104
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:600 → 1008
    HDAC4; Histone deacetylase 4

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049766.1 Alternate UNSW_CanFamBas_1.0

    Range
    49364978..49638565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038638615.1 → XP_038494543.1  histone deacetylase 4 isoform X5

    Conserved Domains (2) summary
    cd10162
    Location:88 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:648 → 1051
    HDAC4; Histone deacetylase 4

  2. XM_038638614.1 → XP_038494542.1  histone deacetylase 4 isoform X4

    Conserved Domains (2) summary
    cd10162
    Location:88 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:648 → 1056
    HDAC4; Histone deacetylase 4

  3. XM_038638616.1 → XP_038494544.1  histone deacetylase 4 isoform X6

    Conserved Domains (2) summary
    cd10162
    Location:83 → 147
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:643 → 1051
    HDAC4; Histone deacetylase 4

  4. XM_038638617.1 → XP_038494545.1  histone deacetylase 4 isoform X7

    Conserved Domains (2) summary
    cd10162
    Location:61 → 125
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:621 → 1029
    HDAC4; Histone deacetylase 4

  5. XM_038638612.1 → XP_038494540.1  histone deacetylase 4 isoform X2

    Conserved Domains (2) summary
    cd10162
    Location:95 → 159
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:653 → 1061
    HDAC4; Histone deacetylase 4

  6. XM_038638613.1 → XP_038494541.1  histone deacetylase 4 isoform X3

    Conserved Domains (2) summary
    cd10162
    Location:95 → 159
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:655 → 1058
    HDAC4; Histone deacetylase 4

  7. XM_038638611.1 → XP_038494539.1  histone deacetylase 4 isoform X1

    Conserved Domains (2) summary
    cd10162
    Location:95 → 159
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:655 → 1063
    HDAC4; Histone deacetylase 4

  8. XM_038638618.1 → XP_038494546.1  histone deacetylase 4 isoform X8

    Conserved Domains (2) summary
    cd10162
    Location:40 → 104
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:600 → 1008
    HDAC4; Histone deacetylase 4

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049246.1 Alternate UU_Cfam_GSD_1.0

    Range
    49597454..49869914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038574380.1 → XP_038430308.1  histone deacetylase 4 isoform X5

    UniProtKB/TrEMBL
    A0A8I3Q401, A0A8P0TJ56

  2. XM_038574379.1 → XP_038430307.1  histone deacetylase 4 isoform X4

    UniProtKB/TrEMBL
    A0A8I3Q401, A0A8P0TJ56

  3. XM_038574382.1 → XP_038430310.1  histone deacetylase 4 isoform X6

    UniProtKB/TrEMBL
    A0A8I3Q401, A0A8P0TJ56

  4. XM_038574383.1 → XP_038430311.1  histone deacetylase 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C0TIE4

  5. XM_038574377.1 → XP_038430305.1  histone deacetylase 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0TIE4

  6. XM_038574378.1 → XP_038430306.1  histone deacetylase 4 isoform X3

    UniProtKB/TrEMBL
    A0A8C0TIE4

  7. XM_038574376.1 → XP_038430304.1  histone deacetylase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0TIE4

  8. XM_038574384.1 → XP_038430312.1  histone deacetylase 4 isoform X8

    UniProtKB/TrEMBL
    A0A8C0TIE4

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    49810705..50083929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038458200.1 → XP_038314128.1  histone deacetylase 4 isoform X5

    UniProtKB/TrEMBL
    A0A8I3Q401, A0A8P0TJ56
    Conserved Domains (2) summary
    cd10162
    Location:88 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:648 → 1051
    HDAC4; Histone deacetylase 4

  2. XM_038458199.1 → XP_038314127.1  histone deacetylase 4 isoform X4

    UniProtKB/TrEMBL
    A0A8I3Q401, A0A8P0TJ56
    Conserved Domains (2) summary
    cd10162
    Location:88 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:648 → 1056
    HDAC4; Histone deacetylase 4

  3. XM_038458201.1 → XP_038314129.1  histone deacetylase 4 isoform X6

    UniProtKB/TrEMBL
    A0A8I3Q401, A0A8P0TJ56
    Conserved Domains (2) summary
    cd10162
    Location:83 → 147
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:643 → 1051
    HDAC4; Histone deacetylase 4

  4. XM_038458202.1 → XP_038314130.1  histone deacetylase 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C0TIE4
    Conserved Domains (2) summary
    cd10162
    Location:61 → 125
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:621 → 1029
    HDAC4; Histone deacetylase 4

  5. XM_038458197.1 → XP_038314125.1  histone deacetylase 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0TIE4
    Conserved Domains (2) summary
    cd10162
    Location:95 → 159
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:653 → 1061
    HDAC4; Histone deacetylase 4

  6. XM_038458198.1 → XP_038314126.1  histone deacetylase 4 isoform X3

    UniProtKB/TrEMBL
    A0A8C0TIE4
    Conserved Domains (2) summary
    cd10162
    Location:95 → 159
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:655 → 1058
    HDAC4; Histone deacetylase 4

  7. XM_038458196.1 → XP_038314124.1  histone deacetylase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0TIE4
    Conserved Domains (2) summary
    cd10162
    Location:95 → 159
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:655 → 1063
    HDAC4; Histone deacetylase 4

  8. XM_038458203.1 → XP_038314131.1  histone deacetylase 4 isoform X8

    UniProtKB/TrEMBL
    A0A8C0TIE4
    Conserved Domains (2) summary
    cd10162
    Location:40 → 104
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:600 → 1008
    HDAC4; Histone deacetylase 4
Nucleotide Protein
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