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LTC4S leukotriene C4 synthase [ Canis lupus familiaris (dog) ]

Gene ID: 607316, updated on 5-Mar-2024

Summary

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Official Symbol
LTC4Sprovided by VGNC
Official Full Name
leukotriene C4 synthaseprovided by VGNC
Primary source
VGNC:VGNC:51742
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
5
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 11 NC_051815.1 (1863608..1871298, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 11 NC_006593.4 (2012534..2020224, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 11 NC_049232.1 (2154596..2162286, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 11 NC_049271.1 (1835205..1842895, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 11 NC_049752.1 (1914372..1922062, complement)

Chromosome 11 - NC_051815.1Genomic Context describing neighboring genes Neighboring gene MRN complex interacting protein Neighboring gene uncharacterized LOC119881637 Neighboring gene sequestosome 1 Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Neighboring gene mastermind like transcriptional coactivator 1 Neighboring gene calnexin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables leukotriene-C4 synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in leukotriene biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
leukotriene C4 synthase
XP_038345662.1
XP_038345663.1
XP_038345664.1
XP_038345665.1
XP_038345666.1
XP_038407681.1
XP_038407683.1
XP_038407684.1
XP_038407685.1
XP_038407686.1
XP_038471569.1
XP_038471570.1
XP_038471571.1
XP_038471572.1
XP_038471573.1
XP_038520029.1
XP_038520036.1
XP_038520043.1
XP_038520048.1
XP_038520056.1
XP_038537057.1
XP_038537058.1
XP_038537059.1
XP_038537060.1
XP_038537061.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051815.1 Reference ROS_Cfam_1.0

    Range
    1863608..1871298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038681132.1 → XP_038537060.1  leukotriene C4 synthase isoform X4

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 129
    MAPEG; MAPEG family

  2. XM_038681133.1 → XP_038537061.1  leukotriene C4 synthase isoform X5

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 129
    MAPEG; MAPEG family

  3. XM_038681130.1 → XP_038537058.1  leukotriene C4 synthase isoform X2

    Conserved Domains (1) summary
    pfam01124
    Location:18 → 121
    MAPEG; MAPEG family

  4. XM_038681129.1 → XP_038537057.1  leukotriene C4 synthase isoform X1

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 129
    MAPEG; MAPEG family

  5. XM_038681131.1 → XP_038537059.1  leukotriene C4 synthase isoform X3

    UniProtKB/TrEMBL
    A0A8C0JMF2, A0A8C0QRC4
    Conserved Domains (1) summary
    pfam01124
    Location:8 → 100
    MAPEG; MAPEG family

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049271.1 Alternate UMICH_Zoey_3.1

    Range
    1835205..1842895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038489737.1 → XP_038345665.1  leukotriene C4 synthase isoform X4

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 129
    MAPEG; MAPEG family

  2. XM_038489738.1 → XP_038345666.1  leukotriene C4 synthase isoform X5

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 129
    MAPEG; MAPEG family

  3. XM_038489735.1 → XP_038345663.1  leukotriene C4 synthase isoform X2

    Conserved Domains (1) summary
    pfam01124
    Location:18 → 121
    MAPEG; MAPEG family

  4. XM_038489734.1 → XP_038345662.1  leukotriene C4 synthase isoform X1

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 129
    MAPEG; MAPEG family

  5. XM_038489736.1 → XP_038345664.1  leukotriene C4 synthase isoform X3

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 100
    MAPEG; MAPEG family

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049752.1 Alternate UNSW_CanFamBas_1.0

    Range
    1914372..1922062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038615644.1 → XP_038471572.1  leukotriene C4 synthase isoform X4

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 129
    MAPEG; MAPEG family

  2. XM_038615645.1 → XP_038471573.1  leukotriene C4 synthase isoform X5

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 129
    MAPEG; MAPEG family

  3. XM_038615642.1 → XP_038471570.1  leukotriene C4 synthase isoform X2

    Conserved Domains (1) summary
    pfam01124
    Location:18 → 121
    MAPEG; MAPEG family

  4. XM_038615641.1 → XP_038471569.1  leukotriene C4 synthase isoform X1

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 129
    MAPEG; MAPEG family

  5. XM_038615643.1 → XP_038471571.1  leukotriene C4 synthase isoform X3

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 100
    MAPEG; MAPEG family

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049232.1 Alternate UU_Cfam_GSD_1.0

    Range
    2154596..2162286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038551757.1 → XP_038407685.1  leukotriene C4 synthase isoform X4

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 129
    MAPEG; MAPEG family

  2. XM_038551758.1 → XP_038407686.1  leukotriene C4 synthase isoform X5

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 129
    MAPEG; MAPEG family

  3. XM_038551755.1 → XP_038407683.1  leukotriene C4 synthase isoform X2

    Conserved Domains (1) summary
    pfam01124
    Location:18 → 121
    MAPEG; MAPEG family

  4. XM_038551753.1 → XP_038407681.1  leukotriene C4 synthase isoform X1

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 129
    MAPEG; MAPEG family

  5. XM_038551756.1 → XP_038407684.1  leukotriene C4 synthase isoform X3

    UniProtKB/TrEMBL
    A0A8C0JMF2, A0A8C0QRC4
    Conserved Domains (1) summary
    pfam01124
    Location:8 → 100
    MAPEG; MAPEG family

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006593.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    2012534..2020224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038664120.1 → XP_038520048.1  leukotriene C4 synthase isoform X4

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 129
    MAPEG; MAPEG family

  2. XM_038664128.1 → XP_038520056.1  leukotriene C4 synthase isoform X5

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 129
    MAPEG; MAPEG family

  3. XM_038664108.1 → XP_038520036.1  leukotriene C4 synthase isoform X2

    Conserved Domains (1) summary
    pfam01124
    Location:18 → 121
    MAPEG; MAPEG family

  4. XM_038664101.1 → XP_038520029.1  leukotriene C4 synthase isoform X1

    Conserved Domains (1) summary
    pfam01124
    Location:8 → 129
    MAPEG; MAPEG family

  5. XM_038664115.1 → XP_038520043.1  leukotriene C4 synthase isoform X3

    UniProtKB/TrEMBL
    A0A8C0JMF2, A0A8C0QRC4
    Conserved Domains (1) summary
    pfam01124
    Location:8 → 100
    MAPEG; MAPEG family
Nucleotide Protein
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