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Ppp2r2b protein phosphatase 2, regulatory subunit B, beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 60660, updated on 13-Apr-2024

Summary

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Official Symbol
Ppp2r2bprovided by RGD
Official Full Name
protein phosphatase 2, regulatory subunit B, betaprovided by RGD
Primary source
RGD:631441
See related
Ensembl:ENSRNOG00000018851 AllianceGenome:RGD:631441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pppr2b2
Summary
Predicted to enable protein phosphatase regulator activity. Involved in several processes, including mitochondrion organization; nervous system development; and positive regulation of neuron apoptotic process. Located in cytosol and mitochondrial outer membrane. Part of protein phosphatase type 2A complex. Colocalizes with cytoskeleton. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to human PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 247.9), Testes (RPKM 74.2) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18p11
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (34904686..35357299, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (34653716..35080889, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (36985709..37421383, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-40S ribosomal protein S27a pseudogene Neighboring gene G protein-coupled receptor 151 Neighboring gene uncharacterized LOC134482938 Neighboring gene uncharacterized LOC108353168 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene serine/threonine kinase 32A Neighboring gene rhox homeobox family member 1-like Neighboring gene dihydropyrimidinase-like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Induction of PP2A Bβ, a regulator of IL-2 deprivation-induced T-cell apoptosis, is deficient in systemic lupus erythematosus. Crispín JC, et al. Proc Natl Acad Sci U S A, 2011 Jul 26. PMID 21746932, Free PMC Article
  2. A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence. Vazquez A, et al. Int J Cancer, 2011 May 15. PMID 20669227, Free PMC Article
  3. Spinocerebellar ataxia type 12 identified in two Italian families may mimic sporadic ataxia. Brussino A, et al. Mov Disord, 2010 Jul 15. PMID 20629122
  4. The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission. Dagda RK, et al. J Biol Chem, 2008 Dec 26. PMID 18940801, Free PMC Article
  5. Unfolding-resistant translocase targeting: a novel mechanism for outer mitochondrial membrane localization exemplified by the Bbeta2 regulatory subunit of protein phosphatase 2A. Dagda RK, et al. J Biol Chem, 2005 Jul 22. PMID 15923182, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Select PP2A heterotrimers oppose desensitization of the TrkA receptor tyrosine kinase, perhaps through dephosphorylation of inhibitory Ser/Thr phosphorylation sites on the receptor itself.
    Title: The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation.
  2. spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission [SCA12]
    Title: The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial fission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial fragmentation involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein phosphatase type 2A complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Names
BRbeta B-regulatory subunit of protein phosphatase 2A
NP_001389311.1
NP_071545.2
XP_017456515.1
XP_017456517.1
XP_038952986.1
XP_038952987.1
XP_038952988.1
XP_038952990.1
XP_038952991.1
XP_038952992.1
XP_038952993.1
XP_038952994.1
XP_038952996.1
XP_038952997.1
XP_038952999.1
XP_038953000.1
XP_063133596.1
XP_063133597.1
XP_063133598.1
XP_063133599.1
XP_063133601.1
XP_063133602.1
XP_063133603.1
XP_063133604.1
XP_063133605.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402382.1 → NP_001389311.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    P36877, Q80W84
    UniProtKB/TrEMBL
    A6J3L2

  2. NM_022209.4 → NP_071545.2  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 1

    See identical proteins and their annotated locations for NP_071545.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6J3L0, Z4YNW7
    Related
    ENSRNOP00000077436.1, ENSRNOT00000107651.1
    Conserved Domains (3) summary
    COG5170
    Location:25 → 441
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:30 → 78
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:24 → 369
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_073588.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    34904686..35357299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277535.1 → XP_063133605.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X14

  2. XM_039097058.2 → XP_038952986.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2

    UniProtKB/TrEMBL
    Z4YNW7
    Conserved Domains (2) summary
    COG5170
    Location:25 → 468
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:30 → 105
    7WD40; WD40 repeat [structural motif]

  3. XM_017601028.3 → XP_017456517.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X12

    UniProtKB/TrEMBL
    A0A0G2K165, Z4YNW7
    Related
    ENSRNOP00000071716.2

  4. XM_063277532.1 → XP_063133602.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X12

    UniProtKB/TrEMBL
    A0A0G2K165

  5. XM_063277533.1 → XP_063133603.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X12

    UniProtKB/TrEMBL
    A0A0G2K165

  6. XM_039097068.2 → XP_038952996.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X7

    UniProtKB/TrEMBL
    Z4YNW7
    Conserved Domains (2) summary
    COG5170
    Location:6 → 447
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:9 → 84
    7WD40; WD40 repeat [structural motif]

  7. XM_039097065.2 → XP_038952993.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X7

    UniProtKB/TrEMBL
    Z4YNW7
    Conserved Domains (2) summary
    COG5170
    Location:6 → 447
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:9 → 84
    7WD40; WD40 repeat [structural motif]

  8. XM_063277528.1 → XP_063133598.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3

  9. XM_039097060.2 → XP_038952988.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3

    UniProtKB/TrEMBL
    Z4YNW7
    Conserved Domains (2) summary
    COG5170
    Location:22 → 465
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:27 → 102
    7WD40; WD40 repeat [structural motif]

  10. XM_039097066.2 → XP_038952994.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X7

    UniProtKB/TrEMBL
    Z4YNW7
    Conserved Domains (2) summary
    COG5170
    Location:6 → 447
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:9 → 84
    7WD40; WD40 repeat [structural motif]

  11. XM_063277531.1 → XP_063133601.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X12

    UniProtKB/TrEMBL
    A0A0G2K165

  12. XM_039097072.2 → XP_038953000.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X14

    UniProtKB/TrEMBL
    A6K6P2
    Conserved Domains (2) summary
    COG5170
    Location:2 → 283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:21 → 57
    7WD40; WD40 repeat [structural motif]

  13. XM_039097069.2 → XP_038952997.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X8

    UniProtKB/TrEMBL
    Z4YNW7
    Conserved Domains (2) summary
    COG5170
    Location:3 → 444
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:6 → 81
    7WD40; WD40 repeat [structural motif]

  14. XM_039097059.2 → XP_038952987.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3

    UniProtKB/TrEMBL
    Z4YNW7
    Conserved Domains (2) summary
    COG5170
    Location:22 → 465
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:27 → 102
    7WD40; WD40 repeat [structural motif]

  15. XM_063277527.1 → XP_063133597.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3

  16. XM_039097071.2 → XP_038952999.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X10

    UniProtKB/TrEMBL
    A0A8I6ANA4, Z4YNW7
    Related
    ENSRNOP00000096088.1
    Conserved Domains (2) summary
    COG5170
    Location:5 → 422
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:11 → 59
    7WD40; WD40 repeat [structural motif]

  17. XM_039097063.2 → XP_038952991.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X5

    UniProtKB/TrEMBL
    Z4YNW7
    Conserved Domains (2) summary
    COG5170
    Location:5 → 449
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:11 → 86
    7WD40; WD40 repeat [structural motif]

  18. XM_063277534.1 → XP_063133604.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X13

    UniProtKB/TrEMBL
    A0A8I6AXN0

  19. XM_039097064.2 → XP_038952992.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X6

    UniProtKB/TrEMBL
    Z4YNW7
    Conserved Domains (2) summary
    COG5170
    Location:1 → 448
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:10 → 85
    7WD40; WD40 repeat [structural motif]

  20. XM_017601026.3 → XP_017456515.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X11

    UniProtKB/TrEMBL
    A0A8I5ZU97, Z4YNW7
    Related
    ENSRNOP00000081049.1

  21. XM_063277529.1 → XP_063133599.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X9

  22. XM_039097062.2 → XP_038952990.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X4

    UniProtKB/TrEMBL
    Z4YNW7
    Related
    ENSRNOP00000041264.5
    Conserved Domains (2) summary
    COG5170
    Location:8 → 449
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:11 → 86
    7WD40; WD40 repeat [structural motif]

  23. XM_063277526.1 → XP_063133596.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36877.2 GenPept UniProtKB/Swiss-Prot:P36877

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