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Acss2 acyl-CoA synthetase short-chain family member 2 [ Mus musculus (house mouse) ]

Gene ID: 60525, updated on 31-Mar-2024

Summary

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Official Symbol
Acss2provided by MGI
Official Full Name
acyl-CoA synthetase short-chain family member 2provided by MGI
Primary source
MGI:MGI:1890410
See related
Ensembl:ENSMUSG00000027605 AllianceGenome:MGI:1890410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ACS; ACAS; Acs1; Acas1; Acas2; aceCS; AceCS1; 1110017C11Rik
Summary
Enables acetate-CoA ligase activity and propionate-CoA ligase activity. Acts upstream of or within acetyl-CoA biosynthetic process. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; liver; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 107.5), subcutaneous fat pad adult (RPKM 101.3) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Acss2 in Genome Data Viewer
Location:
2 H1; 2 77.26 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155359963..155404663)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155518043..155562743)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cytochrome c, somatic pseudogene Neighboring gene gamma-glutamyltransferase 7 Neighboring gene STARR-positive B cell enhancer ABC_E1258 Neighboring gene STARR-positive B cell enhancer ABC_E7875 Neighboring gene acyl-CoA synthetase short-chain family member 2, opposite strand Neighboring gene glutathione synthase, opposite strand 2 Neighboring gene glutathione synthetase Neighboring gene STARR-seq mESC enhancer starr_06145 Neighboring gene STARR-positive B cell enhancer ABC_E6005 Neighboring gene myosin, heavy chain 7B, cardiac muscle, beta Neighboring gene microRNA 499

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer's disease. Lin Y, et al. Mol Neurodegener, 2023 Jul 12. PMID 37438762, Free PMC Article
  2. Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation. Vasudevan NP, et al. Int J Mol Sci, 2023 Feb 12. PMID 36835088, Free PMC Article
  3. Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation. Alexander DC, et al. Proc Natl Acad Sci U S A, 2022 Aug 9. PMID 35921439, Free PMC Article
  4. Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma. Li Z, et al. Cell Metab, 2021 Jan 5. PMID 33406405, Free PMC Article
  5. A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling. Nagati JS, et al. PLoS One, 2019. PMID 31725783, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-kappaB pathway.
    Title: Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-κB pathway.
  2. Gut microbiota regulates hepatic ischemia-reperfusion injury-induced cognitive dysfunction via the HDAC2-ACSS2 axis in mice.
    Title: Gut microbiota regulates hepatic ischemia-reperfusion injury-induced cognitive dysfunction via the HDAC2-ACSS2 axis in mice.
  3. Inhibition of ACSS2 attenuates alcoholic liver steatosis via epigenetically regulating de novo lipogenesis.
    Title: Inhibition of ACSS2 attenuates alcoholic liver steatosis via epigenetically regulating de novo lipogenesis.
  4. ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer's disease.
    Title: ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer's disease.
  5. Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation.
    Title: Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation.
  6. Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation.
    Title: Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation.
  7. Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements.
    Title: Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements.
  8. Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma.
    Title: Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma.
  9. Different Effects of Knockouts in ALDH2 and ACSS2 on Embryonic Stem Cell Differentiation.
    Title: Different Effects of Knockouts in ALDH2 and ACSS2 on Embryonic Stem Cell Differentiation.
  10. Results suggest that ACSS2 gene is associated with human alcoholism and ethanol intake in a free-choice animal model, and even the compulsive-like behavior associated with ethanol use. Finally, slight alterations in metabolism could be responsible for the difference between ethanol non-preferring, ethanol-preferring and compulsive-like ethanol consumption.
    Title: Possible involvement of ACSS2 gene in alcoholism.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: Gssos2

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetate-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables acetate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables propionate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in acetyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acetyl-CoA biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in propionate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acetyl-coenzyme A synthetase, cytoplasmic
Names
acetate--CoA ligase
acetyl-CoA synthetase 1
acetyl-Coenzyme A synthetase 1 (AMP forming)
acetyl-Coenzyme A synthetase 2 (ADP forming)
acetyl-Coenzyme A synthetase 2 (AMP forming)
acyl-activating enzyme
propionate--CoA ligase
NP_062785.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019811.3 → NP_062785.2  acetyl-coenzyme A synthetase, cytoplasmic

    See identical proteins and their annotated locations for NP_062785.2

    Status: VALIDATED

    Source sequence(s)
    AL844852
    Consensus CDS
    CCDS16950.1
    UniProtKB/Swiss-Prot
    Q8BK97, Q9QXG4
    UniProtKB/TrEMBL
    Q8C141, Q8C1A8
    Related
    ENSMUSP00000029135.9, ENSMUST00000029135.15
    Conserved Domains (1) summary
    cd05966
    Location:45 → 685
    ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155359963..155404663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXG4.2 GenPept UniProtKB/Swiss-Prot:Q9QXG4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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