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Matk megakaryocyte-associated tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 60450, updated on 11-Apr-2024

Summary

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Official Symbol
Matkprovided by RGD
Official Full Name
megakaryocyte-associated tyrosine kinaseprovided by RGD
Primary source
RGD:69058
See related
Ensembl:ENSRNOG00000020431 AllianceGenome:RGD:69058
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Batk
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in peptidyl-tyrosine phosphorylation. Predicted to be located in cytoplasm and membrane. Orthologous to human MATK (megakaryocyte-associated tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 166.5), Spleen (RPKM 46.0) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9107711..9116864, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8456990..8465947, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11325246..11334311, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tight junction protein 3 Neighboring gene amyloid beta precursor protein binding family A member 3 Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene zinc finger RNA binding protein 2 Neighboring gene ATCAY kinesin light chain interacting caytaxin Neighboring gene uncharacterized LOC134479805

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Purification, crystallization, small-angle X-ray scattering and preliminary X-ray diffraction analysis of the SH2 domain of the Csk-homologous kinase. Gunn NJ, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Mar 1. PMID 21393838, Free PMC Article
  2. Identification and characterization of Batk, a predominantly brain-specific non-receptor protein tyrosine kinase related to Csk. Kuo SS, et al. J Neurosci Res, 1994 Aug 15. PMID 7807586
  3. Csk-homologous kinase interacts with SHPS-1 and enhances neurite outgrowth of PC12 cells. Mitsuhashi H, et al. J Neurochem, 2008 Apr. PMID 17999719
  4. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, et al. Mamm Genome, 2000 Sep. PMID 10967130
  5. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The CHK SH2 was expressed in Escherichia coli and the purified protein was characterized as monomeric by synchrotron small-angle X-ray scattering in-line with size-exclusion chromatography.
    Title: Purification, crystallization, small-angle X-ray scattering and preliminary X-ray diffraction analysis of the SH2 domain of the Csk-homologous kinase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105436

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
megakaryocyte-associated tyrosine-protein kinase
Names
megakaryocyte-associated tyrosine kinase (non-receptor protein tyrosine kinase)
non-receptor protein kinase protein
protein kinase BATK
tyrosine-protein kinase CTK
NP_068631.1
XP_038935769.1
XP_038935770.1
XP_038935771.1
XP_038935772.1
XP_038935773.1
XP_063120269.1
XP_063120270.1
XP_063120271.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021859.2 → NP_068631.1  megakaryocyte-associated tyrosine-protein kinase

    See identical proteins and their annotated locations for NP_068631.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087726
    UniProtKB/Swiss-Prot
    P41243
    UniProtKB/TrEMBL
    A0A8I6GLP3, A6K8A4
    Related
    ENSRNOP00000027730.4, ENSRNOT00000027730.5
    Conserved Domains (3) summary
    cd09937
    Location:77 → 174
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:9 → 67
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:187 → 441
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    9107711..9116864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264200.1 → XP_063120270.1  megakaryocyte-associated tyrosine-protein kinase isoform X3

    UniProtKB/Swiss-Prot
    P41243
    UniProtKB/TrEMBL
    A6K8A4

  2. XM_039079842.2 → XP_038935770.1  megakaryocyte-associated tyrosine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLP3
    Conserved Domains (3) summary
    cd09937
    Location:77 → 174
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:9 → 67
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:187 → 470
    PKc_like; Protein Kinases, catalytic domain

  3. XM_063264201.1 → XP_063120271.1  megakaryocyte-associated tyrosine-protein kinase isoform X4

  4. XM_039079845.2 → XP_038935773.1  megakaryocyte-associated tyrosine-protein kinase isoform X2

    UniProtKB/TrEMBL
    A0A8I6GLP3
    Conserved Domains (3) summary
    cl15255
    Location:77 → 163
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:9 → 67
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:176 → 459
    PKc_like; Protein Kinases, catalytic domain

  5. XM_063264199.1 → XP_063120269.1  megakaryocyte-associated tyrosine-protein kinase isoform X3

    UniProtKB/Swiss-Prot
    P41243
    UniProtKB/TrEMBL
    A6K8A4

  6. XM_039079841.2 → XP_038935769.1  megakaryocyte-associated tyrosine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLP3
    Conserved Domains (3) summary
    cd09937
    Location:77 → 174
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:9 → 67
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:187 → 470
    PKc_like; Protein Kinases, catalytic domain

  7. XM_039079844.2 → XP_038935772.1  megakaryocyte-associated tyrosine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLP3
    Conserved Domains (3) summary
    cd09937
    Location:77 → 174
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:9 → 67
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:187 → 470
    PKc_like; Protein Kinases, catalytic domain

  8. XM_039079843.2 → XP_038935771.1  megakaryocyte-associated tyrosine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLP3
    Conserved Domains (3) summary
    cd09937
    Location:77 → 174
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:9 → 67
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:187 → 470
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41243.1 GenPept UniProtKB/Swiss-Prot:P41243

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