Prmt1 protein arginine methyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prmt1provided by RGD
Official Full Name: protein arginine methyltransferase 1provided by RGD
Primary source: RGD:62020
See related: Ensembl:ENSRNOG00000026109 AllianceGenome:RGD:62020
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hrmt1l2
Summary: Enables identical protein binding activity; protein-arginine N-methyltransferase activity; and snoRNP binding activity. Involved in several processes, including liver regeneration; positive regulation of erythrocyte differentiation; and positive regulation of hemoglobin biosynthetic process. Acts upstream of or within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine. Located in cytosol; membrane; and nucleus. Part of protein-containing complex. Biomarker of asthma. Orthologous to human PRMT1 (protein arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 215.1), Heart (RPKM 204.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (104595339..104605552, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (95458853..95468176, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (100971132..100980411, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing circRNA LRP6 down-regulates PRMT1 to improve the streptozocin-induced pancreatic beta-cell injury and insulin secretion by sponging miR-9-5p.
Title: Silencing circRNA LRP6 down-regulates PRMT1 to improve the streptozocin-induced pancreatic β-cell injury and insulin secretion by sponging miR-9-5p.
Naturally occurring cancer-associated mutations disrupt oligomerization and activity of protein arginine methyltransferase 1 (PRMT1).
Title: Naturally occurring cancer-associated mutations disrupt oligomerization and activity of protein arginine methyltransferase 1 (PRMT1).
PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytes.
Title: PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytes.
PRMT1 may mediate renal fibroblast activation and renal fibrosis development through activation of the TGF-beta/Smad3 signaling pathway.
Title: Protein arginine methyltransferase 1 mediates renal fibroblast activation and fibrogenesis through activation of Smad3 signaling.
PRMT1 might have a potential importance as a therapeutic target for the treatment of Hypobaric hypoxia-induced maladies.
Title: PRMT1 promotes hyperglycemia in a FoxO1-dependent manner, affecting glucose metabolism, during hypobaric hypoxia exposure, in rat model.
Higher levels of asymmetric dimethylarginine are associated with lower DDAH2 and higher PRMT1 in LPS-induced endometritis rat model.
Title: Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher PRMT1 in LPS-Induced Endometritis Rats.
TGF-beta-induced PRMT1 expression participates in fibroblast proliferation and chronic airway inflammation in ovalbumin-induced asthma.
Title: PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation.
The detailed mechanism of PRMT1-catalyzed asymmetric dimethylation, is reported.
Title: Theoretical insights into catalytic mechanism of protein arginine methyltransferase 1.
higher energy barrier of SDMA formation (DeltaDeltaG(double dagger) = 3.2 kcal/mol as compared with ADMA) may explain the small amount of SDMA generated by M48F-PRMT1
Title: A remodeled protein arginine methyltransferase 1 (PRMT1) generates symmetric dimethylarginine.
Study reports that PRMT1 methylates a multisite peptide substrate in a nonstochastic manner, with less C-terminal preference, consistent with the methylation patterns observed in vivo. With a single targeted arginine, PRMT1 catalyzed the dimethylation in a semiprocessive manner.
Title: Substrate-induced control of product formation by protein arginine methyltransferase 1.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hrmt1l2-rs (e-PCR), detects polymorphism
- UniSTS:143403

Hrmt1l2 (e-PCR), detects polymorphism
- UniSTS:275867

BI285876 (e-PCR)
- UniSTS:244917

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GATOR1 complex binding	ISO Inferred from Sequence Orthology more info
enables GATOR1 complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables S-adenosyl-L-methionine binding	IDA Inferred from Direct Assay more info	PubMed
enables S-adenosyl-L-methionine binding	ISO Inferred from Sequence Orthology more info
enables S-adenosyl-L-methionine binding	ISS Inferred from Sequence or Structural Similarity more info
enables S-adenosylmethionine-dependent methyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone H4R3 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4R3 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables methyl-CpG binding	ISO Inferred from Sequence Orthology more info
enables methyl-CpG binding	ISS Inferred from Sequence or Structural Similarity more info
enables mitogen-activated protein kinase p38 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine omega-N asymmetric methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-arginine omega-N asymmetric methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine omega-N asymmetric methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine omega-N monomethyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-arginine omega-N monomethyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine omega-N monomethyltransferase activity	ISO Inferred from Sequence Orthology more info
enables snoRNP binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
involved_in S-adenosylmethionine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to methionine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to methionine	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of megakaryocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of erythrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hemoglobin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of p38MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of megakaryocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
part_of methylosome	ISO Inferred from Sequence Orthology more info
part_of methylosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein arginine N-methyltransferase 1

Names: heterogeneous nuclear ribonucleoproteins methyltransferase-like 2; histone-arginine N-methyltransferase PRMT1

NP_077339.1

EC 2.1.1.319

XP_006229206.1

EC 2.1.1.319

XP_063128571.1

EC 2.1.1.319

XP_063128577.1

EC 2.1.1.319

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024363.1 → NP_077339.1 protein arginine N-methyltransferase 1

See identical proteins and their annotated locations for NP_077339.1

Status: PROVISIONAL

Source sequence(s)

U60882

UniProtKB/Swiss-Prot

Q63009

UniProtKB/TrEMBL

A0A8L2QUM0, A6JAU8

Related

ENSRNOP00000063624.3, ENSRNOT00000064272.4

Conserved Domains (1) summary

cd02440
Location:74 → 174

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

104595339..104605552 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229144.5 → XP_006229206.1 protein arginine N-methyltransferase 1 isoform X1

See identical proteins and their annotated locations for XP_006229206.1

UniProtKB/TrEMBL

A0A8L2QUM0, A6JAU9

Related

ENSRNOP00000084758.1

Conserved Domains (1) summary

cd02440
Location:92 → 192

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_063272507.1 → XP_063128577.1 protein arginine N-methyltransferase 1 isoform X3

UniProtKB/TrEMBL

A6JAV0
XM_063272501.1 → XP_063128571.1 protein arginine N-methyltransferase 1 isoform X2