Lmna lamin A/C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lmnaprovided by RGD
Official Full Name: lamin A/Cprovided by RGD
Primary source: RGD:620456
See related: Ensembl:ENSRNOG00000019638 AllianceGenome:RGD:620456
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein phosphatase 1 binding activity. Involved in several processes, including cellular senescence; negative regulation of adipose tissue development; and positive regulation of osteoblast differentiation. Located in nuclear matrix. Used to study transient cerebral ischemia. Biomarker of arteriosclerosis. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 472.1), Lung (RPKM 385.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (176237564..176265301, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (173939751..173960423, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (187842884..187863552, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Compromised Biomechanical Properties, Cell-Cell Adhesion and Nanotubes Communication in Cardiac Fibroblasts Carrying the Lamin A/C D192G Mutation.
Title: Compromised Biomechanical Properties, Cell-Cell Adhesion and Nanotubes Communication in Cardiac Fibroblasts Carrying the Lamin A/C D192G Mutation.
Lamin A/C negatively regulated by miR-124-3p modulates apoptosis of vascular smooth muscle cells during cyclic stretch application in rats.
Title: Lamin A/C negatively regulated by miR-124-3p modulates apoptosis of vascular smooth muscle cells during cyclic stretch application in rats.
Suppressed nuclear envelope proteins activate autophagy of vascular smooth muscle cells during cyclic stretch application.
Title: Suppressed nuclear envelope proteins activate autophagy of vascular smooth muscle cells during cyclic stretch application.
Viscoelastic behavior of cardiomyocytes carrying LMNA mutations.
Title: Viscoelastic behavior of cardiomyocytes carrying LMNA mutations.
lamin A/C interacts with Notch signaling, thereby influencing cellular differentiation, and point mutation in LMNA could halt this interaction
Title: Lamin A/C mutation associated with lipodystrophy influences adipogenic differentiation of stem cells through interaction with Notch signaling.
Our findings establish the pathogenetic role of emerin and lamin A/C repression in stretch-induced VSMC proliferation and suggest mechanobiological mechanism underlying this process that involves the sequence-specific binding of emerin and lamin A/C to specific transcription factor motifs.
Title: Nuclear envelope proteins modulate proliferation of vascular smooth muscle cells during cyclic stretch application.
the knockdown of prelamin A and lamin A inhibited the increase of Runx2, osteocalcin and osteopontin gene expression, calcium deposition, nuclear abnormalities and the RUNX2 protein translocation into the nucleus of the cell.
Title: Lamin A is involved in the development of vascular calcification induced by chronic kidney failure and phosphorus load.
Low shear strength suppresses the expression of Nesprin2 and LaminA, which may subsequently modulate the activation of important transcription factors and eventually lead to endothelial cell dysfunction.
Title: Nuclear envelope proteins Nesprin2 and LaminA regulate proliferation and apoptosis of vascular endothelial cells in response to shear stress.
This differential expression pattern of lamin a in retinal neurons suggests that they may be involved in cellular differentiation and expression of cell-specific genes in individual retinal neurons.
Title: Nuclear lamins are differentially expressed in retinal neurons of the adult rat retina.
These findings are supported by coimmunoprecipitation of prelamin A or progerin with BAF in vivo and suggest that BAF could mediate prelamin A-induced chromatin effects.
Title: Lamin A precursor induces barrier-to-autointegration factor nuclear localization.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141321 (e-PCR)
- UniSTS:223317

MARC_3281-3282:991936958:1 (e-PCR)
- UniSTS:231005

BI277711 (e-PCR)
- UniSTS:243848

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 1 binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info
enables structural constituent of nuclear lamina	IEA Inferred from Electronic Annotation more info
enables structural constituent of nuclear lamina	ISO Inferred from Sequence Orthology more info
enables structural constituent of nuclear lamina	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA double-strand break attachment to nuclear envelope	IEA Inferred from Electronic Annotation more info
involved_in DNA double-strand break attachment to nuclear envelope	ISO Inferred from Sequence Orthology more info
involved_in DNA double-strand break attachment to nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular senescence	IEA Inferred from Electronic Annotation more info
involved_in cellular senescence	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within_positive_effect cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect cellular senescence	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment or maintenance of microtubule cytoskeleton polarity	IEA Inferred from Electronic Annotation more info
involved_in establishment or maintenance of microtubule cytoskeleton polarity	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle organ development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cardiac muscle hypertrophy in response to stress	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle hypertrophy in response to stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mesenchymal cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in nuclear envelope organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear envelope organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear envelope organization	ISO Inferred from Sequence Orthology more info
involved_in nuclear envelope organization	ISO Inferred from Sequence Orthology more info
involved_in nuclear envelope organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear pore localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nucleus organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in ventricular cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ventricular cardiac muscle cell development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in lamin filament	IEA Inferred from Electronic Annotation more info
located_in lamin filament	ISO Inferred from Sequence Orthology more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nuclear lamina	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear lamina	IEA Inferred from Electronic Annotation more info
is_active_in nuclear lamina	ISO Inferred from Sequence Orthology more info
is_active_in nuclear lamina	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	IEA Inferred from Electronic Annotation more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: prelamin-A/C

Names: lamin A; lamin C2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002016.2 → NP_001002016.2 prelamin-A/C

See identical proteins and their annotated locations for NP_001002016.2

Status: VALIDATED

Source sequence(s)

CA338388, DN934590, FM031779, FM060776, JAXUCZ010000002

UniProtKB/Swiss-Prot

P48679

UniProtKB/TrEMBL

A6J680, G3V8L3

Related

ENSRNOP00000026705.4, ENSRNOT00000026705.7

Conserved Domains (2) summary

pfam00038
Location:30 → 386

Filament; Intermediate filament protein

pfam00932
Location:434 → 541

LTD; Lamin Tail Domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

176237564..176265301 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282429.1 → XP_063138499.1 prelamin-A/C isoform X1

UniProtKB/TrEMBL

A6J680, G3V8L3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_021755.1: Suppressed sequence

Description

NM_021755.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.