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Birc2 baculoviral IAP repeat-containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60371, updated on 30-Mar-2024

Summary

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Official Symbol
Birc2provided by RGD
Official Full Name
baculoviral IAP repeat-containing 2provided by RGD
Primary source
RGD:620690
See related
Ensembl:ENSRNOG00000010602 AllianceGenome:RGD:620690
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Api2; rIAP1
Summary
Predicted to enable several functions, including FBXO family protein binding activity; chaperone binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in response to cAMP; response to ethanol; and response to hypoxia. Located in XY body; membrane raft; and nucleus. Part of protein-containing complex. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BIRC2 (baculoviral IAP repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 363.4), Thymus (RPKM 214.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (13253697..13273672, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (4968856..4989325, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (6014014..6036668, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556477 Neighboring gene galectin-8 pseudogene Neighboring gene transmembrane protein 123 Neighboring gene baculoviral IAP repeat-containing 3 Neighboring gene RNA guanine-7 methyltransferase activating subunit, pseudogene 1 Neighboring gene ribosomal protein S7, pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The effects of ethanol and the serotonin(1A) agonist ipsapirone on the expression of the serotonin(1A) receptor and several antiapoptotic proteins in fetal rhombencephalic neurons. Druse MJ, et al. Brain Res, 2006 May 30. PMID 16687129
  2. Inhibitors of apoptosis proteins in human cervical cancer. Espinosa M, et al. BMC Cancer, 2006 Feb 27. PMID 16504151, Free PMC Article
  3. Time-dependent apoptosis of alveolar macrophages from rats exposed to bleomycin: involvement of tnf receptor 2. Zhao HW, et al. J Toxicol Environ Health A, 2004 Sep 10. PMID 15371238
  4. Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2. Dong Z, et al. Am J Pathol, 2003 Aug. PMID 12875985, Free PMC Article
  5. Cyclic AMP increases rat inhibitor of apoptosis protein (RIAP1) mRNA in renal mesangial cells. Manderscheid M, et al. Kidney Int, 2002 Mar. PMID 11849428

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LNC01296 Regulates Apoptosis Genes Birc2 and Bak1 by Targeting miRNA-29c and Participates in Neuroprotection During Cerebral Ischemia/Reperfusion Injury in Rats.
    Title: LNC01296 Regulates Apoptosis Genes Birc2 and Bak1 by Targeting miRNA-29c and Participates in Neuroprotection During Cerebral Ischemia/Reperfusion Injury in Rats.
  2. Baculoviral IAP repeatcontaining protein 2 (Birc2) was confirmed a target of miR205 through a dual luciferase reporter assay and western blotting. It was demonstrated that downregulated miR205 decreased apoptosis in H9c2 cells. The apoptosisassociated proteins were further detected in H9c2 cells and rat tissue.
    Title: Short‑term vagus nerve stimulation reduces myocardial apoptosis by downregulating microRNA‑205 in rats with chronic heart failure.
  3. Tnfrsf1a, Birc2 and Birc3 of Schwann cells, not originally regarded as XIAP, were mainly responsible for the inflammation-mediated anti-apoptosis of peripheral nerves.
    Title: Gene network revealed involvements of Birc2, Birc3 and Tnfrsf1a in anti-apoptosis of injured peripheral nerves.
  4. cIAP1 plays a critical role in beta-cell survival under endoplasmic reticulum stress: by promoting ubiquitination and degradation of C/EBP homologous protein (CHOP)
    Title: Cellular inhibitor of apoptosis protein-1 (cIAP1) plays a critical role in β-cell survival under endoplasmic reticulum stress: promoting ubiquitination and degradation of C/EBP homologous protein (CHOP).
  5. Data show that death resistance of hypoxic cells involves multiple factors targeting different stages of apoptosis, with inhibitor of apoptosis protein-2 suppressing caspases in the cytosol.
    Title: Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables FBXO family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
involved_in necroptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of necroptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of ripoptosome assembly involved in necroptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within placenta development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cAMP IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of CD40 receptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in XY body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
baculoviral IAP repeat-containing protein 2
Names
apoptosis inhibitor 2
inhibitor of apoptosis protein
NP_068520.2
XP_006242556.1
XP_006242557.1
XP_017451371.1
XP_063122133.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021752.3 → NP_068520.2  baculoviral IAP repeat-containing protein 2

    See identical proteins and their annotated locations for NP_068520.2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A9K3Y7W9, F1M6X6, Q6P6S1, Q9QZC6
    Conserved Domains (4) summary
    smart00238
    Location:240 → 308
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd08329
    Location:425 → 514
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:362 → 408
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    pfam13920
    Location:538 → 583
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    13253697..13273672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595882.3 → XP_017451371.1  baculoviral IAP repeat-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    Q9QZC6

  2. XM_006242494.4 → XP_006242556.1  baculoviral IAP repeat-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006242556.1

    UniProtKB/TrEMBL
    A0A9K3Y7W9, F1M6X6, Q6P6S1, Q9QZC6
    Related
    ENSRNOP00000014560.5, ENSRNOT00000014560.7
    Conserved Domains (4) summary
    smart00238
    Location:240 → 308
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd08329
    Location:425 → 514
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:362 → 408
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    pfam13920
    Location:538 → 583
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  3. XM_006242495.5 → XP_006242557.1  baculoviral IAP repeat-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006242557.1

    UniProtKB/TrEMBL
    A0A9K3Y7W9, F1M6X6, Q6P6S1, Q9QZC6
    Conserved Domains (4) summary
    smart00238
    Location:240 → 308
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd08329
    Location:425 → 514
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:362 → 408
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    pfam13920
    Location:538 → 583
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  4. XM_063266063.1 → XP_063122133.1  baculoviral IAP repeat-containing protein 2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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