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Arhgef1 Rho guanine nucleotide exchange factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60323, updated on 3-Apr-2024

Summary

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Official Symbol
Arhgef1provided by RGD
Official Full Name
Rho guanine nucleotide exchange factor 1provided by RGD
Primary source
RGD:620951
See related
Ensembl:ENSRNOG00000020130 AllianceGenome:RGD:620951
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lsc; Lbcl2
Summary
Predicted to enable G protein-coupled receptor binding activity and guanyl-nucleotide exchange factor activity. Involved in negative regulation of cell death. Predicted to be located in cytosol and plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 62. Orthologous to human ARHGEF1 (Rho guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 296.9), Spleen (RPKM 246.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q21
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (89626884..89648823)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (80499026..80520954)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (81769212..81797237)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19 Neighboring gene CD79a molecule Neighboring gene ETS repressor factor like Neighboring gene uncharacterized LOC134485104

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Endothelin-1 up-regulates p115RhoGEF in embryonic rat cardiomyocytes during the hypertrophic response. Porchia F, et al. J Recept Signal Transduct Res, 2008. PMID 18569527
  2. The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms. Eisenhaure TM, et al. J Biol Chem, 2003 Aug 15. PMID 12773540
  3. ROS-dependent activation of RhoA/Rho-kinase in pulmonary artery: Role of Src-family kinases and ARHGEF1. MacKay CE, et al. Free Radic Biol Med, 2017 Sep. PMID 28673614, Free PMC Article
  4. A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin. Dubash AD, et al. J Cell Sci, 2007 Nov 15. PMID 17971419
  5. Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway. Varma H, et al. J Biol Chem, 2010 Nov 26. PMID 20858895, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reactive oxygen species and SrcFK activate RhoA via ARHGEF1 in pulmonary artery.
    Title: ROS-dependent activation of RhoA/Rho-kinase in pulmonary artery: Role of Src-family kinases and ARHGEF1.
  2. results indicate that ROCK and its downstream target molecules, which are involved in inducing the hypertrophic response, are also implicated in signaling the up-regulation of the p115RhoGEF protein.
    Title: Endothelin-1 up-regulates p115RhoGEF in embryonic rat cardiomyocytes during the hypertrophic response.
  3. These data establish a previously uncharacterized role for the exchange factors Lsc/p115 RhoGEF and LARG in linking fibronectin signals to downstream RhoA activation.
    Title: A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC108950

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 1
Names
Lymphoid blast crisis-like 2
Rho guanine nucleotide exchange factor (GEF) 1
lbc's second cousin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021694.3 → NP_067726.3  rho guanine nucleotide exchange factor 1

    See identical proteins and their annotated locations for NP_067726.3

    Status: PROVISIONAL

    Source sequence(s)
    BC091218
    UniProtKB/Swiss-Prot
    Q9Z1I6
    UniProtKB/TrEMBL
    Q5BK37
    Related
    ENSRNOP00000072904.2, ENSRNOT00000080840.2
    Conserved Domains (4) summary
    pfam05887
    Location:303 → 409
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    cd08755
    Location:50 → 242
    RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
    smart00325
    Location:418 → 602
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd14679
    Location:636 → 760
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    89626884..89648823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088933.2 → XP_038944861.1  rho guanine nucleotide exchange factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JU01, E9PTJ8
    Related
    ENSRNOP00000059325.4
    Conserved Domains (4) summary
    cd08755
    Location:50 → 242
    RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
    smart00325
    Location:474 → 658
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PRK14086
    Location:275 → 451
    dnaA; chromosomal replication initiator protein DnaA
    cd14679
    Location:692 → 816
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

  2. XM_063272369.1 → XP_063128439.1  rho guanine nucleotide exchange factor 1 isoform X5

  3. XM_063272371.1 → XP_063128441.1  rho guanine nucleotide exchange factor 1 isoform X6

  4. XM_063272361.1 → XP_063128431.1  rho guanine nucleotide exchange factor 1 isoform X2

  5. XM_063272365.1 → XP_063128435.1  rho guanine nucleotide exchange factor 1 isoform X4

  6. XM_063272358.1 → XP_063128428.1  rho guanine nucleotide exchange factor 1 isoform X1

  7. XM_063272364.1 → XP_063128434.1  rho guanine nucleotide exchange factor 1 isoform X3

    UniProtKB/TrEMBL
    Q5BK37
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1I6.1 GenPept UniProtKB/Swiss-Prot:Q9Z1I6

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