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BCL3 BCL3 transcription coactivator [ Homo sapiens (human) ]

Gene ID: 602, updated on 5-Mar-2024

Summary

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Official Symbol
BCL3provided by HGNC
Official Full Name
BCL3 transcription coactivatorprovided by HGNC
Primary source
HGNC:HGNC:998
See related
Ensembl:ENSG00000069399 MIM:109560; AllianceGenome:HGNC:998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCL4; D19S37
Summary
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 8.4), small intestine (RPKM 7.7) and 24 other tissues See more
Orthologs
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Genomic context

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See BCL3 in Genome Data Viewer
Location:
19q13.32
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44747705..44760044)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (47566894..47584794)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45251965..45263301)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3873 Neighboring gene uncharacterized LOC107985306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45192479-45192980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45192981-45193480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45199988-45200593 Neighboring gene CEACAM16, CEACAM19 and PVR antisense RNA 1 Neighboring gene CEA cell adhesion molecule 16, tectorial membrane component Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45240385-45240886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10736 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10737 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45258284-45258994 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45259896-45260547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45261851-45262500 Neighboring gene uncharacterized LOC124900431 Neighboring gene microRNA 8085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14772 Neighboring gene Cbl proto-oncogene C Neighboring gene MPRA-validated peak3507 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14773

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure. Gehrke N, et al. Cell Death Dis, 2022 May 31. PMID 35641486, Free PMC Article
  2. Bcl-3: A Double-Edged Sword in Immune Cells and Inflammation. Liu H, et al. Front Immunol, 2022. PMID 35355979, Free PMC Article
  3. The role of B-Cell Lymphoma-3 (BCL-3) in enabling the hallmarks of cancer: implications for the treatment of colorectal carcinogenesis. Legge DN, et al. Carcinogenesis, 2020 May 14. PMID 31930327, Free PMC Article
  4. BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells. Legge DN, et al. Dis Model Mech, 2019 Mar 4. PMID 30792270, Free PMC Article
  5. BCL3 Expression Is a Potential Prognostic and Predictive Biomarker in Acute Myeloid Leukemia of FAB Subtype M2. Niu Y, et al. Pathol Oncol Res, 2019 Apr. PMID 30357752, Free PMC Article

See all (140) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BCL3 rearrangements in B-cell lymphoid neoplasms occur in two breakpoint clusters associated with different diseases.
    Title: BCL3 rearrangements in B-cell lymphoid neoplasms occur in two breakpoint clusters associated with different diseases.
  2. Bcl-3 regulates T cell function through energy metabolism.
    Title: Bcl-3 regulates T cell function through energy metabolism.
  3. Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR-1343-3p/Bcl-3 axis through TGFbeta/Smad3/EMT signaling.
    Title: Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR-1343-3p/Bcl-3 axis through TGFβ/Smad3/EMT signaling.
  4. Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure.
    Title: Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure.
  5. Bcl-3: A Double-Edged Sword in Immune Cells and Inflammation.
    Title: Bcl-3: A Double-Edged Sword in Immune Cells and Inflammation.
  6. Bcl3 Couples Cancer Stem Cell Enrichment With Pancreatic Cancer Molecular Subtypes.
    Title: Bcl3 Couples Cancer Stem Cell Enrichment With Pancreatic Cancer Molecular Subtypes.
  7. Bcl-3 promotes Wnt signaling by maintaining the acetylation of beta-catenin at lysine 49 in colorectal cancer.
    Title: Bcl-3 promotes Wnt signaling by maintaining the acetylation of β-catenin at lysine 49 in colorectal cancer.
  8. PCAT1 induced by transcription factor YY1 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-216a-3p to up-regulate oncogene BCL3.
    Title: PCAT1 induced by transcription factor YY1 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-216a-3p to up-regulate oncogene BCL3.
  9. Bcl-3 promotes multi-modal tumour cell migration via NF-kappaB1 mediated regulation of Cdc42.
    Title: Bcl-3 promotes multi-modal tumour cell migration via NF-κB1 mediated regulation of Cdc42.
  10. BCL-3 and beta-catenin signaling and tumor staging in colorectal cancer.
    Title: BCL-3 and β-catenin signaling and tumor staging in colorectal cancer.
Submit: New GeneRIF Correction See all GeneRIFs (87)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Leukemia/lymphoma, B-cell, 3
MedGen: CN375896 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
EBI GWAS Catalog
Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
EBI GWAS Catalog
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of B-cell CLL/lymphoma 3 (BCL3) in human B cells PubMed
Tat tat HIV-1 Tat upregulates the expression of B-cell CLL/lymphoma 3 (BCL3) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in T cell apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in T-helper 1 type immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in T-helper 2 cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in antimicrobial humoral response IEA
Inferred from Electronic Annotation
more info
  
involved_in canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to protozoan IEA
Inferred from Electronic Annotation
more info
  
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
  
involved_in follicular dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in germinal center formation IEA
Inferred from Electronic Annotation
more info
  
involved_in humoral immune response mediated by circulating immunoglobulin IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in marginal zone B cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of T cell apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of interleukin-8 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of type II interferon production IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA binding IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of non-canonical NF-kappaB signal transduction IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to UV-C IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spleen development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Bcl3-Bcl10 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Bcl3/NF-kappaB2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Bcl3/NF-kappaB2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
B-cell lymphoma 3 protein
Names
B cell CLL/lymphoma 3
B-cell leukemia/lymphoma 3
B-cell lymphoma 3-encoded protein
BCL-3
chronic lymphatic leukemia protein
proto-oncogene BCL3

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052809.1 RefSeqGene

    Range
    11088..22424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005178.5 → NP_005169.2  B-cell lymphoma 3 protein

    See identical proteins and their annotated locations for NP_005169.2

    Status: REVIEWED

    Source sequence(s)
    AC092066, BC064993, BU501187
    Consensus CDS
    CCDS12642.2
    UniProtKB/Swiss-Prot
    P20749
    Related
    ENSP00000164227.5, ENST00000164227.10
    Conserved Domains (2) summary
    sd00045
    Location:241 → 272
    ANK; ANK repeat [structural motif]
    cl39094
    Location:137 → 334
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    44747705..44760044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027110.2 → XP_016882599.1  B-cell lymphoma 3 protein isoform X2

    UniProtKB/TrEMBL
    B7Z3N9
    Related
    ENST00000403534.7
    Conserved Domains (4) summary
    cd00204
    Location:160 → 289
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:170 → 265
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:117 → 172
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:201 → 232
    ANK; ANK repeat [structural motif]

  2. XM_011527198.4 → XP_011525500.3  B-cell lymphoma 3 protein isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    47566894..47584794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321687.1 → XP_054177662.1  B-cell lymphoma 3 protein isoform X4

  2. XM_054321686.1 → XP_054177661.1  B-cell lymphoma 3 protein isoform X3

  3. XM_054321688.1 → XP_054177663.1  B-cell lymphoma 3 protein isoform X5

  4. XM_054321692.1 → XP_054177667.1  B-cell lymphoma 3 protein isoform X2

    UniProtKB/TrEMBL
    B7Z3N9

  5. XM_054321689.1 → XP_054177664.1  B-cell lymphoma 3 protein isoform X6

  6. XM_054321690.1 → XP_054177665.1  B-cell lymphoma 3 protein isoform X7

  7. XM_054321691.1 → XP_054177666.1  B-cell lymphoma 3 protein isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20749.2 GenPept UniProtKB/Swiss-Prot:P20749

Gene LinkOut

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