RLF RLF zinc finger [Homo sapiens (human)] - Gene

Summary

Official Symbol: RLFprovided by HGNC
Official Full Name: RLF zinc fingerprovided by HGNC
Primary source: HGNC:HGNC:10025
See related: Ensembl:ENSG00000117000 MIM:180610; AllianceGenome:HGNC:10025
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZN-15L; ZNF292L
Summary: Predicted to enable DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within histone H3-K4 monomethylation and regulation of DNA methylation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bone marrow (RPKM 13.7), testis (RPKM 7.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p34.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (40161387..40240921)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (40030849..40110388)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (40627059..40706593)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
capsid	gag	The interaction of HIV-1 CA with human cellular rearranged L-myc fusion protein (RLF) is identified by yeast two-hybrid screen	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-74649 (e-PCR)
- UniSTS:69141

SHGC-74651 (e-PCR)
- UniSTS:18729

AL033651 (e-PCR)
- UniSTS:93486

WI-11868 (e-PCR)
- UniSTS:2360

RH143286 (e-PCR)
- UniSTS:232533

A009G05 (e-PCR)
- UniSTS:77674

WI-12261 (e-PCR)
- UniSTS:83056

G32521 (e-PCR)
- UniSTS:117106

SHGC-74705 (e-PCR)
- UniSTS:74099

G20854 (e-PCR)
- UniSTS:40080

A006I34 (e-PCR)
- UniSTS:40081

D1S2131 (e-PCR)
- UniSTS:68550

SHGC-74652 (e-PCR)
- UniSTS:2793

SHGC-74663 (e-PCR)
- UniSTS:6636

GDB:593224 (e-PCR)
- UniSTS:157944

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: zinc finger protein Rlf

Names: Zn-15 related; rearranged L-myc fusion gene protein; rearranged L-myc fusion sequence; zn-15-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012421.4 → NP_036553.2 zinc finger protein Rlf

See identical proteins and their annotated locations for NP_036553.2

Status: VALIDATED

Source sequence(s)

BC113666, BM542854

Consensus CDS

CCDS448.1

UniProtKB/Swiss-Prot

Q13129, Q14CQ1, Q9NU60

UniProtKB/TrEMBL

Q59GL0

Related

ENSP00000361857.4, ENST00000372771.5

Conserved Domains (2) summary

COG5236
Location:645 → 832

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:716 → 736

ZF_C2H2; C2H2 Zn finger [structural motif]