Ackr2 atypical chemokine receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ackr2provided by MGI
Official Full Name: atypical chemokine receptor 2provided by MGI
Primary source: MGI:MGI:1891697
See related: Ensembl:ENSMUSG00000044534 AllianceGenome:MGI:1891697
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D6; CCR9; CCR10; Ccbp2; Cmkbr9
Summary: Enables C-C chemokine binding activity and C-C chemokine receptor activity. Acts upstream of or within signal transduction. Predicted to be located in several cellular components, including actin filament; cytosol; and nucleus. Predicted to be active in external side of plasma membrane. Is expressed in central nervous system and retina. Orthologous to human ACKR2 (atypical chemokine receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 18.6), spleen adult (RPKM 7.1) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F4; 9 72.71 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (121727421..121740177)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (121898355..121911075)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis.
Title: The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis.
ACKR2 limits skin fibrosis and hair loss through IFN-beta.
Title: ACKR2 limits skin fibrosis and hair loss through IFN-β.
Analysis of lung stromal expression of the atypical chemokine receptor ACKR2 reveals unanticipated expression in murine blood endothelial cells.
Title: Analysis of lung stromal expression of the atypical chemokine receptor ACKR2 reveals unanticipated expression in murine blood endothelial cells.
ACKR2 dampens CCL5 levels and the consequent recruitment of CCR5(+) T helper 1 (Th1).
Title: ACKR2 contributes to pulmonary dysfunction by shaping CCL5:CCR5-dependent recruitment of lymphocytes during influenza A infection in mice.
ACKR2 expression regulates inflammation in tumour-microenvironment.
Title: Role of atypical chemokine receptor ACKR2 in experimental oral squamous cell carcinogenesis.
Atypical chemokine receptor 2 (ACKR2) is a expressed in most hypothalamic cells that is modulated by dietary intervention and acts to reduce diet-induced inflammation, leading to improved glucose tolerance due to improved insulin action.
Title: Hypothalamic expression of the atypical chemokine receptor ACKR2 is involved in the systemic regulation of glucose tolerance.
CKR2 is important in limiting persistent inflammation, tubular loss, and renal fibrosis after ischemic acute kidney injury and, thus, can prevent progression to chronic renal disease.
Title: The Atypical Chemokine Receptor 2 Limits Progressive Fibrosis after Acute Ischemic Kidney Injury.
data indicate that ACKR2 may have a protective role during sepsis, and the absence of ACKR2 leads to exacerbated chemokine accumulation, neutrophil infiltration, and damage to vital organs.
Title: The Atypical Chemokine Receptor ACKR2 is Protective Against Sepsis.
this study shows that Ackr2 constrains NK cell migratory activity and promotes metastasis
Title: The Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis.
ACKR2 controls the CC chemokine expression that drives the influx of CCR2(+) and CCR5(+) IFNgamma-producing gammadeltaT cells, tuning the Th17 response that mediated pulmonary fibrosis triggered by bleomycin instillation.
Title: The atypical chemokine receptor ACKR2 drives pulmonary fibrosis by tuning influx of CCR2(+) and CCR5(+) IFNγ-producing γδT cells in mice.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine binding	IPI Inferred from Physical Interaction more info	PubMed
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables chemokine receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scavenger receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: atypical chemokine receptor 2

Names: C-C chemokine receptor D6; D6 beta-chemokine receptor; chemokine decoy receptor D6; chemokine-binding protein 2; chemokine-binding protein D6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276719.1 → NP_001263648.1 atypical chemokine receptor 2

See identical proteins and their annotated locations for NP_001263648.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC164092, AC165080

Consensus CDS

CCDS23640.1

UniProtKB/Swiss-Prot

O08707, Q8CEG1

Related

ENSMUSP00000148966.2, ENSMUST00000214340.2

Conserved Domains (2) summary

cd14964
Location:48 → 72

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:46 → 322

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_021609.4 → NP_067622.2 atypical chemokine receptor 2

See identical proteins and their annotated locations for NP_067622.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC164092, AC165080

Consensus CDS

CCDS23640.1

UniProtKB/Swiss-Prot

O08707, Q8CEG1

Related

ENSMUSP00000050119.4, ENSMUST00000050327.5

Conserved Domains (2) summary

cd14964
Location:48 → 72

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:46 → 322

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

121727421..121740177

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512203.5 → XP_006512266.1 atypical chemokine receptor 2 isoform X1

See identical proteins and their annotated locations for XP_006512266.1

UniProtKB/Swiss-Prot

O08707, Q8CEG1

Conserved Domains (2) summary

cd14964
Location:48 → 72

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:46 → 322

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily