Ltb4r leukotriene B4 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ltb4rprovided by RGD
Official Full Name: leukotriene B4 receptorprovided by RGD
Primary source: RGD:620410
See related: AllianceGenome:RGD:620410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BLT1; BLT-1; Ltb4r1; LTB4-R1
Summary: Enables leukotriene receptor activity. Involved in inflammatory response. Located in membrane raft. Used to study carotid artery disease. Orthologous to human LTB4R (leukotriene B4 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 2.8), Spleen (RPKM 2.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (33233120..33235636)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (29263199..29265716)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (34449299..34453352)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study verified that both BLT1 mRNA and BLT1 protein expressions were markedly increased after subarachnoid hemorrhage and elevated BLT1 expressions were mainly found in neurons, microglia and endothelial cells rather than astrocytes. We also demonstrated that there a significant positive correlation between BLT1 and nuclear p65 protein expressions in the same specific time course.
Title: Expression and cell distribution of leukotriene B4 receptor 1 in the rat brain cortex after experimental subarachnoid hemorrhage.
BLT1 and BLT2 were involved in synovial cell proliferation.
Title: [Involvement of leukotrine B4 receptors in the inflammatory responses and immunological regulation in vitro].
LTB4 down-regulates airway contraction and inflammation through activation of the hypothalamic-pituitary-adrenal axis via its BLT1 receptor.
Title: Intracerebroventricular injection of leukotriene B4 attenuates antigen-induced asthmatic response via BLT1 receptor stimulating HPA-axis in sensitized rats.
FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions.
Title: FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions.
phosphorylation-independent mechanisms regulate beta-arrestin association and internalization of BLT1
Title: Phosphorylation-independent beta-arrestin translocation and internalization of leukotriene B4 receptors.
The time-dependent expression of Ltb4r in experimental arthritis was studied.
Title: Time-dependent expression of leukotriene B4 receptors in rat collagen-induced arthritis.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables leukotriene B4 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables leukotriene B4 receptor activity	ISO Inferred from Sequence Orthology more info
enables leukotriene receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in leukotriene signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leukotriene B4 receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021656.2 → NP_067688.1 leukotriene B4 receptor 1

See identical proteins and their annotated locations for NP_067688.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

Q9R0Q2

UniProtKB/TrEMBL

A6KH52

Conserved Domains (1) summary

pfam00001
Location:37 → 285

7tm_1; 7 transmembrane receptor (rhodopsin family)