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Kmo kynurenine 3-monooxygenase [ Rattus norvegicus (Norway rat) ]

Gene ID: 59113, updated on 2-May-2024

Summary

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Official Symbol
Kmoprovided by RGD
Official Full Name
kynurenine 3-monooxygenaseprovided by RGD
Primary source
RGD:620610
See related
Ensembl:ENSRNOG00000003709 AllianceGenome:RGD:620610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables kynurenine 3-monooxygenase activity. Involved in several processes, including carboxylic acid metabolic process; cellular response to interleukin-1; and positive regulation of glutamate secretion, neurotransmission. Located in extracellular space and mitochondrial outer membrane. Used to study schizophrenia. Biomarker of mental depression. Orthologous to human KMO (kynurenine 3-monooxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 356.0), Kidney (RPKM 306.2) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
13q24
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (90089340..90121108)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (87557080..87589334)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (93684324..93715378)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096320 Neighboring gene fumarate hydratase Neighboring gene uncharacterized LOC134481597 Neighboring gene small ribosomal subunit protein eS1-like Neighboring gene opsin 3 Neighboring gene CHM like Rab escort protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The inhibition of the kynurenine pathway prevents behavioral disturbances and oxidative stress in the brain of adult rats subjected to an animal model of schizophrenia. Réus GZ, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2018 Feb 2. PMID 29030243
  2. Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis. Walker AL, et al. J Med Chem, 2017 Apr 27. PMID 28398044
  3. Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model. Rojewska E, et al. Neuropharmacology, 2016 Mar. PMID 26524415
  4. Expression of the kynurenine pathway enzymes in the pancreatic islet cells. Activation by cytokines and glucolipotoxicity. Liu JJ, et al. Biochim Biophys Acta, 2015 May. PMID 25675848
  5. Development of LC/MS/MS, high-throughput enzymatic and cellular assays for the characterization of compounds that inhibit kynurenine monooxygenase (KMO). Winkler D, et al. J Biomol Screen, 2013 Sep. PMID 23690293

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding ISO
Inferred from Sequence Orthology
more info
  
enables FAD binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NAD(P)H oxidase H2O2-forming activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD(P)H oxidase H2O2-forming activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables kynurenine 3-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kynurenine 3-monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kynurenine 3-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables kynurenine 3-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
Inferred from Electronic Annotation
more info
  
involved_in L-kynurenine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NAD metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NAD metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in anthranilate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in kynurenic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in kynurenine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in kynurenine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in kynurenine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of glutamate secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of glutamate secretion, neurotransmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in quinolinate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to salt stress ISO
Inferred from Sequence Orthology
more info
  
involved_in tryptophan catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kynurenine 3-monooxygenase
Names
kynurenine 3-hydroxylase
NP_067604.1
XP_006250387.1
XP_006250389.1
XP_008768017.1
XP_038946972.1
XP_038946973.1
XP_038946974.1
XP_038946975.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021593.2 → NP_067604.1  kynurenine 3-monooxygenase

    See identical proteins and their annotated locations for NP_067604.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    O88867
    UniProtKB/TrEMBL
    A0A8I6AUG8, A6JGB4
    Related
    ENSRNOP00000005005.3, ENSRNOT00000005005.7
    Conserved Domains (2) summary
    COG0654
    Location:24 → 396
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
    cl21454
    Location:55 → 330
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    90089340..90121108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250327.5 → XP_006250389.1  kynurenine 3-monooxygenase isoform X2

    UniProtKB/TrEMBL
    A0A8I6AUG8
    Conserved Domains (2) summary
    COG0654
    Location:7 → 329
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
    cl21454
    Location:51 → 256
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_039091044.2 → XP_038946972.1  kynurenine 3-monooxygenase isoform X1

    UniProtKB/TrEMBL
    A0A8I6AUG8
    Conserved Domains (1) summary
    COG0654
    Location:24 → 396
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]

  3. XM_006250325.5 → XP_006250387.1  kynurenine 3-monooxygenase isoform X1

    UniProtKB/TrEMBL
    A0A8I6AUG8
    Conserved Domains (1) summary
    COG0654
    Location:24 → 396
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]

  4. XM_039091046.2 → XP_038946974.1  kynurenine 3-monooxygenase isoform X5

    Conserved Domains (1) summary
    COG0654
    Location:24 → 323
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]

  5. XM_039091045.2 → XP_038946973.1  kynurenine 3-monooxygenase isoform X3

    UniProtKB/TrEMBL
    A0A8I6AUG8
    Conserved Domains (1) summary
    cl30692
    Location:23 → 315
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]

  6. XM_008769795.4 → XP_008768017.1  kynurenine 3-monooxygenase isoform X4

    Conserved Domains (1) summary
    cl21454
    Location:54 → 221
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  7. XM_039091047.2 → XP_038946975.1  kynurenine 3-monooxygenase isoform X6

    Conserved Domains (2) summary
    cl30692
    Location:47 → 189
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
    cl21454
    Location:89 → 146
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. XR_005492281.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88867.1 GenPept UniProtKB/Swiss-Prot:O88867

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