Pcbp4 poly(rC) binding protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcbp4provided by MGI
Official Full Name: poly(rC) binding protein 4provided by MGI
Primary source: MGI:MGI:1890471
See related: Ensembl:ENSMUSG00000023495 AllianceGenome:MGI:1890471
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AlphaCP-4; 1200003L19Rik
Summary: Predicted to enable mRNA 3'-UTR binding activity. Acts upstream of or within negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator and negative regulation of mRNA splicing, via spliceosome. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; dorsal root ganglion; lung; metanephros; and olfactory epithelium. Orthologous to human PCBP4 (poly(rC) binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in whole brain E14.5 (RPKM 109.3), CNS E14 (RPKM 91.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 57.54 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (106330181..106341211)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (106452982..106464012)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the p53-PCBP4-ZFP871 axis represents a novel feedback loop in the p53 pathway.
Title: Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW822005 (e-PCR)
- UniSTS:208445

Pcbp4 (e-PCR), detects polymorphism
- UniSTS:479192

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: poly(rC)-binding protein 4

Names: alpha-CP4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021567.5 → NP_067542.3 poly(rC)-binding protein 4

See identical proteins and their annotated locations for NP_067542.3

Status: VALIDATED

Source sequence(s)

AK005383, AK077632, CA321789, CJ162439, CJ174803

Consensus CDS

CCDS23479.1

UniProtKB/Swiss-Prot

P57724, Q91VR3

UniProtKB/TrEMBL

A0A0R4J044, Q8BP63

Related

ENSMUSP00000024260.7, ENSMUST00000024260.14

Conserved Domains (2) summary

cd00105
Location:243 → 305

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:103 → 167

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

106330181..106341211

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511779.4 → XP_006511842.1 poly(rC)-binding protein 4 isoform X1

See identical proteins and their annotated locations for XP_006511842.1

UniProtKB/Swiss-Prot

P57724, Q91VR3

UniProtKB/TrEMBL

A0A0R4J044, Q8BP63

Conserved Domains (2) summary

cd00105
Location:243 → 305

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:103 → 167

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
XM_030244480.1 → XP_030100340.1 poly(rC)-binding protein 4 isoform X1

UniProtKB/Swiss-Prot

P57724, Q91VR3

UniProtKB/TrEMBL

A0A0R4J044, Q8BP63

Conserved Domains (2) summary

cd00105
Location:243 → 305

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:103 → 167

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
XM_030244484.2 → XP_030100344.1 poly(rC)-binding protein 4 isoform X2

Conserved Domains (2) summary

cd00105
Location:243 → 305

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:103 → 167

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
XM_030244482.2 → XP_030100342.1 poly(rC)-binding protein 4 isoform X1

UniProtKB/Swiss-Prot

P57724, Q91VR3

UniProtKB/TrEMBL

A0A0R4J044, Q8BP63

Conserved Domains (2) summary

cd00105
Location:243 → 305

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:103 → 167

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
XM_030244483.1 → XP_030100343.1 poly(rC)-binding protein 4 isoform X1

UniProtKB/Swiss-Prot

P57724, Q91VR3

UniProtKB/TrEMBL

A0A0R4J044, Q8BP63

Conserved Domains (2) summary

cd00105
Location:243 → 305

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:103 → 167

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
XM_006511781.2 → XP_006511844.1 poly(rC)-binding protein 4 isoform X2

Conserved Domains (2) summary

cd00105
Location:243 → 305

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:103 → 167

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
XM_006511782.5 → XP_006511845.1 poly(rC)-binding protein 4 isoform X3

See identical proteins and their annotated locations for XP_006511845.1

Conserved Domains (1) summary

cd02396
Location:103 → 167

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
XM_006511783.5 → XP_006511846.1 poly(rC)-binding protein 4 isoform X4

See identical proteins and their annotated locations for XP_006511846.1

Conserved Domains (1) summary

cd02396
Location:103 → 167

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
XM_030244481.2 → XP_030100341.1 poly(rC)-binding protein 4 isoform X1

UniProtKB/Swiss-Prot

P57724, Q91VR3

UniProtKB/TrEMBL

A0A0R4J044, Q8BP63

Conserved Domains (2) summary

cd00105
Location:243 → 305

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:103 → 167

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...