U.S. flag

An official website of the United States government

Rab2a RAB2A, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 59021, updated on 4-Jan-2025

Summary

Official Symbol
Rab2aprovided by MGI
Official Full Name
RAB2A, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1928750
See related
Ensembl:ENSMUSG00000047187 AllianceGenome:MGI:1928750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rab2; 9330148M11Rik
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in macroautophagy. Located in Golgi apparatus and autophagosome membrane. Is expressed in dorsal root ganglion; eye; foregut; limb; and limb mesenchyme. Orthologous to human RAB2A (RAB2A, member RAS oncogene family). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E18 (RPKM 79.3), adrenal adult (RPKM 75.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rab2a in Genome Data Viewer
Location:
4 A1; 4 3.63 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (8535661..8607708)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (8535469..8607702)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09520 Neighboring gene predicted gene 11810 Neighboring gene ribosomal protein L23 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09521 Neighboring gene predicted gene, 42253 Neighboring gene predicted gene 8273

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding  
enables GDP binding  
enables GTP binding  
enables GTP binding  
enables GTP binding  
enables GTPase activity  
enables GTPase activity  
enables GTPase activity  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in Golgi organization  
involved_in Golgi organization  
acts_upstream_of_or_within intracellular protein transport PubMed 
involved_in macroautophagy PubMed 
involved_in macroautophagy  
involved_in vesicle-mediated transport  
involved_in vesicle-mediated transport  
Component Evidence Code Pubs
is_active_in Golgi apparatus  
located_in Golgi apparatus PubMed 
is_active_in Golgi membrane  
located_in Golgi membrane  
located_in Golgi membrane  
located_in acrosomal vesicle  
located_in autophagosome membrane PubMed 
located_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane  
located_in melanosome  
located_in membrane  
located_in neuronal cell body  
located_in perinuclear region of cytoplasm  
is_active_in synaptic vesicle membrane  

General protein information

Preferred Names
ras-related protein Rab-2A
Names
GTP-binding protein
RAB2, member RAS oncogene family
NP_001398756.1
NP_001398757.1
NP_067493.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411827.1NP_001398756.1  ras-related protein Rab-2A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL732627, AL806521
  2. NM_001411828.1NP_001398757.1  ras-related protein Rab-2A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL732627, AL806521
  3. NM_021518.4NP_067493.1  ras-related protein Rab-2A isoform 1

    See identical proteins and their annotated locations for NP_067493.1

    Status: VALIDATED

    Source sequence(s)
    AL732627, AL806521
    Consensus CDS
    CCDS17955.1
    UniProtKB/Swiss-Prot
    P53994, Q3UK45
    UniProtKB/TrEMBL
    Q0PD65, Q6PDZ3
    Related
    ENSMUSP00000057664.8, ENSMUST00000060232.8
    Conserved Domains (1) summary
    cl27030
    Location:1212
    Ras; Ras family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    8535661..8607708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.