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Sh3rf1 SH3 domain containing ring finger 1 [ Mus musculus (house mouse) ]

Gene ID: 59009, updated on 5-Mar-2024

Summary

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Official Symbol
Sh3rf1provided by MGI
Official Full Name
SH3 domain containing ring finger 1provided by MGI
Primary source
MGI:MGI:1913066
See related
Ensembl:ENSMUSG00000031642 AllianceGenome:MGI:1913066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Posh; Sh3md2; 2200003J05Rik
Summary
Enables MAP-kinase scaffold activity. Involved in neuron migration; positive regulation of JNK cascade; and regulation of alpha-beta T cell activation. Located in lamellipodium. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human SH3RF1 (SH3 domain containing ring finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 9.0), lung adult (RPKM 8.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B3.1; 8 30.94 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (61677117..61918327)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (61224083..61465293)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21578 Neighboring gene STARR-positive B cell enhancer ABC_E10500 Neighboring gene STARR-positive B cell enhancer ABC_E6639 Neighboring gene predicted gene, 18394 Neighboring gene chloride channel, voltage-sensitive 3 Neighboring gene STARR-positive B cell enhancer ABC_E11383 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 1 Neighboring gene STARR-seq mESC enhancer starr_21581 Neighboring gene RIKEN cDNA 1700001D01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:63837915-63838110 Neighboring gene STARR-positive B cell enhancer mm9_chr8:63838783-63839083 Neighboring gene STARR-seq mESC enhancer starr_21584 Neighboring gene RIKEN cDNA 5730405A17 gene Neighboring gene predicted gene, 40499 Neighboring gene predicted gene 10015 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10501 Neighboring gene STARR-seq mESC enhancer starr_21586 Neighboring gene STARR-seq mESC enhancer starr_21587 Neighboring gene predicted gene, 53435 Neighboring gene STARR-seq mESC enhancer starr_21588 Neighboring gene STARR-seq mESC enhancer starr_21589 Neighboring gene STARR-seq mESC enhancer starr_21591 Neighboring gene carbonyl reductase 4 Neighboring gene palladin, cytoskeletal associated protein Neighboring gene STARR-seq mESC enhancer starr_21593 Neighboring gene predicted gene, 35254

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. POSH Regulates CD4+ T Cell Differentiation and Survival. Cunningham CA, et al. J Immunol, 2016 May 15. PMID 27084103, Free PMC Article
  2. Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs. Kukekov NV, et al. J Biol Chem, 2006 Jun 2. PMID 16571722
  3. POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function. Yao M, et al. Cell Rep, 2022 Apr 5. PMID 35385725
  4. POSH is an intracellular signal transducer for the axon outgrowth inhibitor Nogo66. Dickson HM, et al. J Neurosci, 2010 Oct 6. PMID 20926658, Free PMC Article
  5. The scaffold protein POSH regulates axon outgrowth. Taylor J, et al. Mol Biol Cell, 2008 Dec. PMID 18829867, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function.
    Title: POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function.
  2. The pro-apoptotic JNK scaffold protein POSH mediates CHMP2BIntron5-associated toxicity in animal models of frontotemporal dementia.
    Title: The pro-apoptotic JNK scaffold POSH/SH3RF1 mediates CHMP2BIntron5-associated toxicity in animal models of frontotemporal dementia.
  3. this study shows that POSH is essential for the integration of cell-type-specific signals that regulate the differentiation, survival, and function of T cells
    Title: POSH Regulates CD4+ T Cell Differentiation and Survival.
  4. identify plenty of SH3 (POSH) and JNK-interacting protein 1 (JIP-1) as a multiprotein scaffold network for TCR-mediated JNK1 activation in CD8(+) T cells.
    Title: The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells.
  5. a mechanism by which POSH regulates the localization of activated Rac1 and F-actin assembly to control PCDLP formation and subsequent somal translocation of migratory neurons.
    Title: POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration.
  6. An intracellular signaling pathway for process outgrowth inhibition by Nogo66 implicates the POSH complex as a therapeutic target to enhance axon outgrowth and plasticity in the injured central nervous system.
    Title: POSH is an intracellular signal transducer for the axon outgrowth inhibitor Nogo66.
  7. Results suggest that the molecular scaffold protein POSH assembles an inhibitory complex that links to the actin-myosin network to regulate neuronal process outgrowth.
    Title: The scaffold protein POSH regulates axon outgrowth.
  8. POSH and JIPs directly associate with one another to form a multiprotein complex, PJAC (POSH-JIP apoptotic complex), that includes all of the known kinase components of the pathway.
    Title: Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs.
  9. Siah1 is a binding partner for POSH (plenty of SH3s), a scaffold component of the apoptotic JNK pathway
    Title: Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MAP-kinase scaffold activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of CD4-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of CD8-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase SH3RF1
Names
RING-type E3 ubiquitin transferase SH3RF1
SH3 domain-containing RING finger protein 1
SH3 multiple domains 2
SH3 multiple domains protein 2
plenty of SH3 domains
plenty of SH3s
putative E3 ubiquitin-protein ligase SH3RF1
NP_067481.2
XP_011240533.1
XP_036010097.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021506.3 → NP_067481.2  E3 ubiquitin-protein ligase SH3RF1

    Status: VALIDATED

    Source sequence(s)
    AC117196, AC134339
    Consensus CDS
    CCDS40348.1
    UniProtKB/Swiss-Prot
    O70254, Q3UG42, Q69ZI1, Q6P9M8, Q8BR66, Q8C2T5
    UniProtKB/TrEMBL
    E9QQ33
    Related
    ENSMUSP00000034060.6, ENSMUST00000034060.7
    Conserved Domains (5) summary
    cd11785
    Location:836 → 890
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    cd11930
    Location:200 → 254
    SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
    PHA03247
    Location:539 → 851
    PHA03247; large tegument protein UL36; Provisional
    cd16748
    Location:8 → 55
    RING-HC_SH3RF1; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 1 (SH3RF1) and similar proteins
    cl17036
    Location:455 → 509
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    61677117..61918327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242231.2 → XP_011240533.1  E3 ubiquitin-protein ligase SH3RF1 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GSY0
    Related
    ENSMUSP00000148118.2, ENSMUST00000209611.2
    Conserved Domains (5) summary
    cd11930
    Location:200 → 254
    SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
    PHA03247
    Location:539 → 832
    PHA03247; large tegument protein UL36; Provisional
    cd00162
    Location:12 → 52
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl17036
    Location:455 → 509
    SH3; Src Homology 3 domain superfamily
    cl17238
    Location:8 → 55
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_036154204.1 → XP_036010097.1  E3 ubiquitin-protein ligase SH3RF1 isoform X1

    UniProtKB/Swiss-Prot
    O70254, Q3UG42, Q69ZI1, Q6P9M8, Q8BR66, Q8C2T5
    UniProtKB/TrEMBL
    E9QQ33
    Conserved Domains (5) summary
    cd11785
    Location:836 → 890
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    cd11930
    Location:200 → 254
    SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
    PHA03247
    Location:539 → 851
    PHA03247; large tegument protein UL36; Provisional
    cd16748
    Location:8 → 55
    RING-HC_SH3RF1; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 1 (SH3RF1) and similar proteins
    cl17036
    Location:455 → 509
    SH3; Src Homology 3 domain superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198678.1: Suppressed sequence

    Description
    NM_198678.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZI1.2 GenPept UniProtKB/Swiss-Prot:Q69ZI1

Gene LinkOut

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