Pole3 polymerase (DNA directed), epsilon 3 (p17 subunit) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pole3provided by MGI
Official Full Name: polymerase (DNA directed), epsilon 3 (p17 subunit)provided by MGI
Primary source: MGI:MGI:1933378
See related: Ensembl:ENSMUSG00000028394 AllianceGenome:MGI:1933378
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: YBL1; 1810034K18Rik
Summary: Predicted to enable chromatin DNA binding activity. Predicted to be involved in several processes, including chromatin organization; histone H3 acetylation; and leading strand elongation. Predicted to be located in nucleus. Predicted to be part of CHRAC and epsilon DNA polymerase complex. Is expressed in several structures, including alimentary system; cranium; genitourinary system; nervous system; and sensory organ. Orthologous to human POLE3 (DNA polymerase epsilon 3, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 65.6), liver E14 (RPKM 42.8) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 33.17 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (62440889..62443305, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (62523798..62525014, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA-templated DNA replication	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in leading strand elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ATAC complex	ISO Inferred from Sequence Orthology more info
part_of CHRAC	IBA Inferred from Biological aspect of Ancestor more info
part_of CHRAC	NAS Non-traceable Author Statement more info	PubMed
part_of epsilon DNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of epsilon DNA polymerase complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA polymerase epsilon subunit 3

Names: DNA polymerase II subunit 3; DNA polymerase epsilon subunit p17; NF-YB-like protein; YB-like protein 1

NP_067473.2

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021498.3 → NP_067473.2 DNA polymerase epsilon subunit 3

See identical proteins and their annotated locations for NP_067473.2

Status: VALIDATED

Source sequence(s)

AL732594

Consensus CDS

CCDS18244.1

UniProtKB/TrEMBL

A0A0R4J091

Related

ENSMUSP00000030091.4, ENSMUST00000030091.10

Conserved Domains (1) summary

cl23735
Location:1 → 105

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...