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Gng7 G protein subunit gamma 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 58979, updated on 5-Mar-2024

Summary

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Official Symbol
Gng7provided by RGD
Official Full Name
G protein subunit gamma 7provided by RGD
Primary source
RGD:61860
See related
Ensembl:ENSRNOG00000019857 AllianceGenome:RGD:61860
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hg3b
Summary
Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of adenylate cyclase activity. Predicted to act upstream of or within behavioral fear response; locomotory behavior; and receptor guanylyl cyclase signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Orthologous to human GNG7 (G protein subunit gamma 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 84.4) and Kidney (RPKM 12.3) See more
Orthologs
human mouse all
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Genomic context

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Location:
7q11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9348148..9411924)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8697458..8761239)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11565740..11629519)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093772 Neighboring gene DIRAS family GTPase 1 Neighboring gene uncharacterized LOC102553301 Neighboring gene transfer RNA proline (anticodon AGG) 48 Neighboring gene growth arrest and DNA-damage-inducible, beta Neighboring gene uncharacterized LOC134479806 Neighboring gene lamin B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GNG7 silencing promotes the proliferation and differentiation of placental cytotrophoblasts in preeclampsia rats through activation of the mTOR signaling pathway. Lai WS, et al. Int J Mol Med, 2019 May. PMID 30864685, Free PMC Article
  2. G-protein gamma 7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatum. Watson JB, et al. J Neurosci Res, 1994 Sep 1. PMID 7807587
  3. Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production. Schwindinger WF, et al. J Biol Chem, 2003 Feb 21. PMID 12488442
  4. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
  5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GNG7 silencing repressed apoptosis and enhanced the proliferation and differentiation of placental cytotrophoblasts in preeclampsia rats through activation of the mTOR signaling pathway.
    Title: GNG7 silencing promotes the proliferation and differentiation of placental cytotrophoblasts in preeclampsia rats through activation of the mTOR signaling pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within behavioral fear response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within receptor guanylyl cyclase signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Names
guanine nucleotide binding protein (G protein), gamma 7 subunit
guanine nucleotide binding protein, gamma 7
heterotrimeric guanine nucleotide-binding protein 3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024138.1 → NP_077052.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

    See identical proteins and their annotated locations for NP_077052.1

    Status: PROVISIONAL

    Source sequence(s)
    L23219
    UniProtKB/Swiss-Prot
    P43425, Q45QK4
    Conserved Domains (1) summary
    smart00224
    Location:8 → 69
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    9348148..9411924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595070.3 → XP_017450559.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

    UniProtKB/Swiss-Prot
    P43425, Q45QK4
    Conserved Domains (1) summary
    smart00224
    Location:8 → 69
    GGL; G protein gamma subunit-like motifs

  2. XM_039079813.2 → XP_038935741.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

    UniProtKB/Swiss-Prot
    P43425, Q45QK4
    Conserved Domains (1) summary
    smart00224
    Location:8 → 69
    GGL; G protein gamma subunit-like motifs

  3. XM_039079814.2 → XP_038935742.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

    UniProtKB/Swiss-Prot
    P43425, Q45QK4
    Conserved Domains (1) summary
    smart00224
    Location:8 → 69
    GGL; G protein gamma subunit-like motifs

  4. XM_039079815.2 → XP_038935743.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

    UniProtKB/Swiss-Prot
    P43425, Q45QK4
    Conserved Domains (1) summary
    smart00224
    Location:8 → 69
    GGL; G protein gamma subunit-like motifs

  5. XM_039079812.2 → XP_038935740.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

    UniProtKB/Swiss-Prot
    P43425, Q45QK4
    Conserved Domains (1) summary
    smart00224
    Location:8 → 69
    GGL; G protein gamma subunit-like motifs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43425.2 GenPept UniProtKB/Swiss-Prot:P43425

Gene LinkOut

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