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Sult4a1 sulfotransferase family 4A, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 58953, updated on 30-Mar-2024

Summary

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Official Symbol
Sult4a1provided by RGD
Official Full Name
sulfotransferase family 4A, member 1provided by RGD
Primary source
RGD:69292
See related
Ensembl:ENSRNOG00000046975 AllianceGenome:RGD:69292
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ST4A1; Sultx3; Sulta41
Summary
Predicted to enable identical protein binding activity and sulfotransferase activity. Involved in dendrite arborization. Located in cytoplasm. Orthologous to human SULT4A1 (sulfotransferase family 4A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 404.1) See more
Orthologs
human mouse all
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Genomic context

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Location:
7q34
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (117096064..117120714, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (115216066..115240156, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (124958546..124982602, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 6 Neighboring gene uncharacterized LOC120093701 Neighboring gene uncharacterized LOC134479758 Neighboring gene patatin-like phospholipase domain containing 5 Neighboring gene patatin-like phospholipase domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SULT4A1 Modulates Synaptic Development and Function by Promoting the Formation of PSD-95/NMDAR Complex. Culotta L, et al. J Neurosci, 2020 Sep 9. PMID 32801157, Free PMC Article
  2. Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain. Falany CN, et al. Biochem J, 2000 Mar 15. PMID 10698717, Free PMC Article
  3. Cytosolic Aryl sulfotransferase 4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1. Mitchell DJ, et al. Mol Pharmacol, 2009 Aug. PMID 19439498
  4. Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization. Sakakibara Y, et al. Gene, 2002 Feb 20. PMID 12039030
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dendrite arborization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sulfur compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sulfotransferase 4A1
Names
NST
brain sulfotransferase-like protein
nervous system sulfotransferase
rBR-STL
sulfotransferase-related protein
NP_113829.1
XP_017450556.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031641.2 → NP_113829.1  sulfotransferase 4A1

    See identical proteins and their annotated locations for NP_113829.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    P63047
    UniProtKB/TrEMBL
    A6HTA9, A6HTB0
    Related
    ENSRNOP00000066760.1, ENSRNOT00000075099.3
    Conserved Domains (1) summary
    pfam00685
    Location:45 → 277
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    117096064..117120714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595067.3 → XP_017450556.1  sulfotransferase 4A1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AMX8, A6HTB1
    Related
    ENSRNOP00000094830.1
    Conserved Domains (1) summary
    pfam00685
    Location:45 → 230
    Sulfotransfer_1; Sulfotransferase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63047.1 GenPept UniProtKB/Swiss-Prot:P63047

Gene LinkOut

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