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Ptafr platelet-activating factor receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 58949, updated on 3-Apr-2024

Summary

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Official Symbol
Ptafrprovided by RGD
Official Full Name
platelet-activating factor receptorprovided by RGD
Primary source
RGD:61897
See related
Ensembl:ENSRNOG00000013231 AllianceGenome:RGD:61897
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables mitogen-activated protein kinase binding activity and platelet activating factor receptor activity. Involved in several processes, including positive regulation of gene expression; positive regulation of transport; and regulation of cellular extravasation. Located in plasma membrane. Used to study several diseases, including acute kidney failure; neutropenia; perinatal necrotizing enterocolitis; pleurisy; and transient cerebral ischemia. Biomarker of conjunctivitis; sciatic neuropathy; and transient cerebral ischemia. Orthologous to human PTAFR (platelet activating factor receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 63.9), Lung (RPKM 25.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (150049322..150079060)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144765770..144795057)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150746284..150775675)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ATP synthase inhibitory factor subunit 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 Neighboring gene microRNA 3583 Neighboring gene uncharacterized LOC102548282 Neighboring gene EYA transcriptional coactivator and phosphatase 3 Neighboring gene sphingomyelin phosphodiesterase, acid-like 3B Neighboring gene XK related 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Myocardial ischemia-reperfusion injury is probably due to the excessive production of mitochondrial ROS caused by the activation of 5-HT degradation system mediated by PAF receptor. Jin J, et al. Mol Immunol, 2023 Mar. PMID 36682136
  2. Mechanism and dose-effect of Ginkgolide B on severe acute pancreatitis of rats. Ji RL, et al. World J Gastroenterol, 2011 May 7. PMID 21633536, Free PMC Article
  3. Anti-ischaemic effects of bilobalide on neonatal rat cardiomyocytes and the involvement of the platelet-activating factor receptor. Maerz S, et al. Biosci Rep, 2011 Oct. PMID 21391918, Free PMC Article
  4. Platelet activating factor blocks interkinetic nuclear migration in retinal progenitors through an arrest of the cell cycle at the S/G2 transition. Fragel-Madeira L, et al. PLoS One, 2011 Jan 27. PMID 21298035, Free PMC Article
  5. Hepatic stellate cells may be potential effectors of platelet activating factor induced portal hypertension. Chen Y, et al. World J Gastroenterol, 2008 Jan 14. PMID 18186558, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myocardial ischemia-reperfusion injury is probably due to the excessive production of mitochondrial ROS caused by the activation of 5-HT degradation system mediated by PAF receptor.
    Title: Myocardial ischemia-reperfusion injury is probably due to the excessive production of mitochondrial ROS caused by the activation of 5-HT degradation system mediated by PAF receptor.
  2. MiR-30b-5p and miR-22-3p restrain the fibrogenesis of post-myocardial infarction in mice via targeting PTAFR.
    Title: MiR-30b-5p and miR-22-3p restrain the fibrogenesis of post-myocardial infarction in mice via targeting PTAFR.
  3. In hypoxic tissue, PAFR protein expression is up-regulated, but is reduced in the bilobalide treated tissue.
    Title: Anti-ischaemic effects of bilobalide on neonatal rat cardiomyocytes and the involvement of the platelet-activating factor receptor.
  4. These data show the histological localization of PAF synthases and its receptor in the spinal cord following peripheral nerve injury.
    Title: Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury.
  5. PAF inhibition interkinetic nuclear migration (IKNM) in retinal proliferating progenitors depended on the PAF receptor, Erk and p38 pathways and Chk1
    Title: Platelet activating factor blocks interkinetic nuclear migration in retinal progenitors through an arrest of the cell cycle at the S/G2 transition.
  6. Cirrhosis sensitizes hepatic stellate cells to PAF by elevating its receptor level
    Title: Hepatic stellate cells may be potential effectors of platelet activating factor induced portal hypertension.
  7. Platelet activating factor receptor (PAF-R) plays an important role in occurrence and development of severe acute pancreatitis. BN52021 exerts biological effects through competitively inhibiting the binding of increased both PAF and PAF-R expression.
    Title: Significance of platelet activating factor receptor expression in pancreatic tissues of rats with severe acute pancreatitis and effects of BN52021.
  8. PAF receptor gene expression may be subject to down-regulation in the perifocal regions of cerebral infarction after cerebral ischemia-reperfusion.
    Title: Down-regulation of platelet-activating factor receptor gene expression during focal reversible cerebral ischemia in rats.
  9. differential activation of both G(i) and G(q) by PAFR likely mediate specific as well as redundant signaling pathways
    Title: Activation and regulation of platelet-activating factor receptor: role of G(i) and G(q) in receptor-mediated chemotactic, cytotoxic, and cross-regulatory signals.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
  
enables lipopolysaccharide immune receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables platelet activating factor receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables platelet activating factor receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to cAMP IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to fatty acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to gravity IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inositol trisphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in parturition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cellular extravasation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gastro-intestinal system smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of inositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of leukocyte tethering or rolling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of maternal process involved in parturition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neutrophil degranulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to dexamethasone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organophosphorus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to symbiotic bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transcytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
platelet-activating factor receptor
Names
PAF-R
PAFr

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053321.2 → NP_445773.1  platelet-activating factor receptor

    See identical proteins and their annotated locations for NP_445773.1

    Status: PROVISIONAL

    Source sequence(s)
    BC072491
    UniProtKB/Swiss-Prot
    P46002
    UniProtKB/TrEMBL
    A6ISU3
    Related
    ENSRNOP00000079229.1, ENSRNOT00000097551.1
    Conserved Domains (1) summary
    pfam00001
    Location:33 → 292
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    150049322..150079060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288332.1 → XP_063144402.1  platelet-activating factor receptor isoform X1

    UniProtKB/Swiss-Prot
    P46002
    UniProtKB/TrEMBL
    A6ISU3

  2. XM_006239063.5 → XP_006239125.1  platelet-activating factor receptor isoform X1

    See identical proteins and their annotated locations for XP_006239125.1

    UniProtKB/Swiss-Prot
    P46002
    UniProtKB/TrEMBL
    A6ISU3
    Related
    ENSRNOP00000085904.1
    Conserved Domains (1) summary
    pfam00001
    Location:33 → 292
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. XM_006239064.4 → XP_006239126.1  platelet-activating factor receptor isoform X1

    See identical proteins and their annotated locations for XP_006239126.1

    UniProtKB/Swiss-Prot
    P46002
    UniProtKB/TrEMBL
    A6ISU3
    Conserved Domains (1) summary
    pfam00001
    Location:33 → 292
    7tm_1; 7 transmembrane receptor (rhodopsin family)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46002.1 GenPept UniProtKB/Swiss-Prot:P46002

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