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Pdcd2 programmed cell death 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 58934, updated on 13-Apr-2024

Summary

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Official Symbol
Pdcd2provided by RGD
Official Full Name
programmed cell death 2provided by RGD
Primary source
RGD:61887
See related
Ensembl:ENSRNOG00000001490 AllianceGenome:RGD:61887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme binding activity. Involved in programmed cell death. Located in nucleus. Orthologous to human PDCD2 (programmed cell death 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 163.6), Spleen (RPKM 138.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (65158034..65163524, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (56484947..56490437, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (57512968..57518458, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102557016 Neighboring gene proteasome 20S subunit beta 1 Neighboring gene TATA box binding protein Neighboring gene BRCA1 associated RING domain 1, pseudogene 1 Neighboring gene PR/SET domain 9 Neighboring gene uncharacterized LOC102551889

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PDCD2 knockdown inhibits erythroid but not megakaryocytic lineage differentiation of human hematopoietic stem/progenitor cells. Kokorina NA, et al. Exp Hematol, 2012 Dec. PMID 22922207, Free PMC Article
  2. PDCD2, a protein whose expression is repressed by BCL6, induces apoptosis in human cells by activation of the caspase cascade. Baron BW, et al. Blood Cells Mol Dis, 2010 Aug 15. PMID 20605493
  3. Identification of mRNAs associated with programmed cell death in immature thymocytes. Owens GP, et al. Mol Cell Biol, 1991 Aug. PMID 2072913, Free PMC Article
  4. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, et al. Proteomics, 2005 Jul. PMID 15942958
  5. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Armour SM, et al. Mol Cell Biol, 2013 Apr. PMID 23382074, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hematopoietic stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in programmed cell death IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
programmed cell death protein 2
Names
zinc finger protein Rp-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031638.1 → NP_113826.1  programmed cell death protein 2

    See identical proteins and their annotated locations for NP_113826.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    G3V666, P47816
    UniProtKB/TrEMBL
    A6KB50
    Related
    ENSRNOP00000002040.4, ENSRNOT00000002040.5
    Conserved Domains (2) summary
    pfam01753
    Location:134 → 171
    zf-MYND; MYND finger
    pfam04194
    Location:225 → 338
    PDCD2_C; Programmed cell death protein 2, C-terminal putative domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    65158034..65163524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47816.2 GenPept UniProtKB/Swiss-Prot:P47816

Gene LinkOut

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