Cysltr1 cysteinyl leukotriene receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cysltr1provided by MGI
Official Full Name: cysteinyl leukotriene receptor 1provided by MGI
Primary source: MGI:MGI:1926218
See related: Ensembl:ENSMUSG00000052821 AllianceGenome:MGI:1926218
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cyslt1; CysLT1R
Summary: Enables leukotriene receptor activity. Acts upstream of or within several processes, including calcium ion transport; chemotaxis; and inflammatory response to antigenic stimulus. Is integral component of plasma membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in allergic disease; asthma; and rhinitis. Orthologous to human CYSLTR1 (cysteinyl leukotriene receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in placenta adult (RPKM 1.9), bladder adult (RPKM 1.0) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: X 47.36 cM; X D

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (105617952..105647329, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (106576509..106603679, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of astrocyte CysLT1R ameliorates depression-like behaviors in mice by modulating glutamate synaptic transmission.
Title: Deficiency of astrocyte CysLT(1)R ameliorates depression-like behaviors in mice by modulating glutamate synaptic transmission.
Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption.
Title: Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption.
RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R.
Title: RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R.
Montelukast attenuates interleukin IL-1beta-induced oxidative stress and apoptosis in chondrocytes by inhibiting CYSLTR1 (Cysteinyl Leukotriene Receptor 1) and activating KLF2 (Kruppel Like Factor 2).
Title: Montelukast attenuates interleukin IL-1β-induced oxidative stress and apoptosis in chondrocytes by inhibiting CYSLTR1 (Cysteinyl Leukotriene Receptor 1) and activating KLF2 (Kruppel Like Factor 2).
Cysteinyl leukotriene induces eosinophil extracellular trap formation via cysteinyl leukotriene 1 receptor in a murine model of asthma.
Title: Cysteinyl leukotriene induces eosinophil extracellular trap formation via cysteinyl leukotriene 1 receptor in a murine model of asthma.
these findings highlight the essential role of cysLT1R in suppressing pancreatic insulin secretion, and potentially provided a new insight into understanding the mechanical regulation of glucose homeostasis.
Title: Cysteinyl leukotriene receptor 1 regulates glucose-stimulated insulin secretion (GSIS).
Cysteinyl leukotriene receptor 1 (cysLT1R) regulates osteoclast differentiation and bone resorption.
Title: Cysteinyl leukotriene receptor 1 (cysLT1R) regulates osteoclast differentiation and bone resorption.
Montelukast also served a protective role in a murine ovariectomy (OVX) and unloadinginduced bone loss model. Altogether, these results confirmed that the CysLTR1 antagonist exerted an inhibitory effect on OC formation in vitro and in vivo. It may be useful for the treatment of bone diseases associated with excessive bone resorption.
Title: Montelukast inhibits RANKL‑induced osteoclast formation and bone loss via CysLTR1 and P2Y12.
The study presents a genetic approach in a colitis-associated colon cancer model further supporting an important role for CysLT1R signaling in colon tumorigenesis, driving immune mediators to promote immune cell infiltration in tumors.
Title: Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer.
Mechanistically, the effect of montelukast on osteoblastic differentiation acted by activating the extracellular regulated protein kinases (ERK) pathway. The obtained results suggested that montelukast promotes proliferation and differentiation in osteoblasts exposed to overload mechanics.
Title: Antagonism of cysteinyl leukot-riene receptor 1 (cysLT1R) by montelukast regulates differentiation of MC3T3-E1 cells under overloaded mechanical environment.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB147369 (e-PCR)
- UniSTS:186176

PMC30125P1 (e-PCR)
- UniSTS:272475

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables cysteinyl leukotriene receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables leukotriene receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables leukotriene receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chemotaxis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cysteinyl leukotriene receptor 1

Names: LTD4 receptor; cysteinyl leukotriene D4 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001281859.1 → NP_001268788.1 cysteinyl leukotriene receptor 1 isoform a

See identical proteins and their annotated locations for NP_001268788.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AK033476, AL732460

Consensus CDS

CCDS41098.1

UniProtKB/Swiss-Prot

Q544P1, Q99JA4, Q9JJ71, Q9JK47

Related

ENSMUSP00000063520.4, ENSMUST00000064892.4

Conserved Domains (2) summary

pfam00001
Location:55 → 310

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:47 → 264

7tm_4; Olfactory receptor
NM_001281862.1 → NP_001268791.1 cysteinyl leukotriene receptor 1 isoform b

See identical proteins and their annotated locations for NP_001268791.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AL732460

UniProtKB/Swiss-Prot

Q99JA4

Conserved Domains (1) summary

cd15158
Location:26 → 308

7tmA_CysLTR1; cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_021476.5 → NP_067451.2 cysteinyl leukotriene receptor 1 isoform a

See identical proteins and their annotated locations for NP_067451.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AK033476, AL732460

Consensus CDS

CCDS41098.1

UniProtKB/Swiss-Prot

Q544P1, Q99JA4, Q9JJ71, Q9JK47

Related

ENSMUSP00000109108.2, ENSMUST00000113480.2

Conserved Domains (2) summary

pfam00001
Location:55 → 310

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:47 → 264

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

105617952..105647329 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162055.1 → XP_036017948.1 cysteinyl leukotriene receptor 1 isoform X1

Conserved Domains (1) summary

cd15158
Location:26 → 308

7tmA_CysLTR1; cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors