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Prokr1 prokineticin receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 58182, updated on 11-Apr-2024

Summary

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Official Symbol
Prokr1provided by MGI
Official Full Name
prokineticin receptor 1provided by MGI
Primary source
MGI:MGI:1929676
See related
Ensembl:ENSMUSG00000049409 AllianceGenome:MGI:1929676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkr1; Gpr73; Pk-r1; EG-VEGFR1
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and negative regulation of apoptotic process. Predicted to act upstream of or within circadian rhythm. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; eye; gut; metanephros; and reproductive system. Orthologous to human PROKR1 (prokineticin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 3.3), liver E14.5 (RPKM 2.0) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 D1; 6 38.28 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (87555568..87567741, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87578586..87590762, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein 10 Neighboring gene Rho GTPase activating protein 25 Neighboring gene STARR-positive B cell enhancer ABC_E861 Neighboring gene STARR-positive B cell enhancer ABC_E4843 Neighboring gene STARR-positive B cell enhancer ABC_E3663 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:87492045-87492293 Neighboring gene STARR-seq mESC enhancer starr_16556 Neighboring gene STARR-positive B cell enhancer ABC_E680 Neighboring gene STARR-seq mESC enhancer starr_16558 Neighboring gene predicted gene, 34222 Neighboring gene STARR-seq mESC enhancer starr_16560 Neighboring gene predicted gene, 34312 Neighboring gene STARR-seq mESC enhancer starr_16563 Neighboring gene aprataxin and PNKP like factor Neighboring gene predicted gene, 46964

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PROKR1 delivery by cell-derived vesicles restores the myogenic potential of Prokr1-deficient C2C12 myoblasts.
    Title: PROKR1 delivery by cell-derived vesicles restores the myogenic potential of Prokr1-deficient C2C12 myoblasts.
  2. Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to beta-arrestin 2.
    Title: Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.
  3. Prokineticin receptor 1 ameliorates insulin resistance in skeletal muscle.
    Title: Prokineticin receptor 1 ameliorates insulin resistance in skeletal muscle.
  4. Upon high fat diet exposure, PKR1 (tcf-/-) mice displayed excessive fat deposition in the atrioventricular groove, perivascular area, and pericardium, which was accompanied by an impaired vascular network and cardiac dysfunction.
    Title: Prokineticin receptor-1-dependent paracrine and autocrine pathways control cardiac tcf21(+) fibroblast progenitor cell transformation into adipocytes and vascular cells.
  5. The study shows that PK2beta ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through prokineticin receptor 1.
    Title: PK2β ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through PKR1 receptor.
  6. The authors discovered that PKR1 regulates epicardial-mesenchymal transition (EMT) for epicardial-derived progenitor cell (EPDC), formation. This event affects at least three consequential steps during heart development: (i) EPDC and cardiomyocyte proliferation involved in thickening of an outer compact ventricular chamber wall, (ii) rhythmicity, (iii) formation of coronary circulation.
    Title: Prokineticin receptor-1 signaling promotes Epicardial to Mesenchymal Transition during heart development.
  7. These results establish PKR1 via NFATc3 as a crucial modifier of mesenchymal-epithelial transition processing to the development of nephron.
    Title: Prokineticin receptor 1 is required for mesenchymal-epithelial transition in kidney development.
  8. show that MRAP2 significantly and specifically inhibits PKR1 signaling.
    Title: The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1.
  9. Data show that the prokineticins and their receptors PROK2, PKR1 and PKR2 contributes to altered sensitivity in diabetic neuropathy and its inhibition blocked both allodynia and inflammatory events underlying disease.
    Title: Antagonism of the Prokineticin System Prevents and Reverses Allodynia and Inflammation in a Mouse Model of Diabetes.
  10. These results suggest PKR1 to be a crucial player in the preadipocyte proliferation and differentiation.
    Title: Prokineticin receptor 1 as a novel suppressor of preadipocyte proliferation and differentiation to control obesity.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within circadian rhythm TAS
Traceable Author Statement
more info
 PubMed 
involved_in coronary vasculature development TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prokineticin receptor 1
Names
G-protein coupled receptor 73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355655.1 → NP_001342584.1  prokineticin receptor 1

    Status: VALIDATED

    Source sequence(s)
    AC125171
    Consensus CDS
    CCDS20323.1
    UniProtKB/Swiss-Prot
    Q3U0M4, Q6PD11, Q9JKL1
    Related
    ENSMUSP00000144999.2, ENSMUST00000204682.3
    Conserved Domains (1) summary
    cd15204
    Location:63 → 353
    7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_021381.4 → NP_067356.2  prokineticin receptor 1

    See identical proteins and their annotated locations for NP_067356.2

    Status: VALIDATED

    Source sequence(s)
    AC125171, BC059003
    Consensus CDS
    CCDS20323.1
    UniProtKB/Swiss-Prot
    Q3U0M4, Q6PD11, Q9JKL1
    Related
    ENSMUSP00000059034.8, ENSMUST00000050887.9
    Conserved Domains (1) summary
    cd15204
    Location:63 → 353
    7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    87555568..87567741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506433.5 → XP_006506496.1  prokineticin receptor 1 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:18 → 48
    7tm_GPCRs; TM helix 3 [structural motif]
    cl28897
    Location:1 → 234
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_006506432.5 → XP_006506495.1  prokineticin receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006506495.1

    UniProtKB/Swiss-Prot
    Q3U0M4, Q6PD11, Q9JKL1
    Conserved Domains (1) summary
    cd15204
    Location:63 → 353
    7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JKL1.2 GenPept UniProtKB/Swiss-Prot:Q9JKL1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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