gart phosphoribosylglycinamide formyltransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gartprovided by ZNC
Official Full Name: phosphoribosylglycinamide formyltransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000616-14
See related: AllianceGenome:ZFIN:ZDB-GENE-000616-14
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb33g04
Summary: Predicted to enable phosphoribosylamine-glycine ligase activity and phosphoribosylformylglycinamidine cyclo-ligase activity. Acts upstream of or within camera-type eye development; chordate embryonic development; and pigmentation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytosol. Is expressed in several structures, including alar plate midbrain region; digestive system; nervous system; pigment cell; and yolk syncytial layer. Orthologous to human GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (973067..1005061, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (139908..188514, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Two recessive zebrafish mutations that affect de novo purine synthesis, gart and paics, were analyzed.
Title: Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development.

Submit: New GeneRIF Correction

General gene information

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Markers

fd02g01.x1 (e-PCR)
- UniSTS:194872

fb33g04 (e-PCR)
- UniSTS:189027

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphoribosylamine-glycine ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoribosylamine-glycine ligase activity	IEA Inferred from Electronic Annotation more info
enables phosphoribosylformylglycinamidine cyclo-ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoribosylformylglycinamidine cyclo-ligase activity	IEA Inferred from Electronic Annotation more info
enables phosphoribosylglycinamide formyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in adenine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within purine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within purine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: trifunctional purine biosynthetic protein adenosine-3

NP_571692.1

EC 2.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131617.1 → NP_571692.1 trifunctional purine biosynthetic protein adenosine-3

See identical proteins and their annotated locations for NP_571692.1

Status: PROVISIONAL

Source sequence(s)

AF257743

UniProtKB/TrEMBL

Q9I9E6

Conserved Domains (7) summary

cd02196
Location:469 → 767

PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...

cd08645
Location:814 → 996

FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)

PRK00885
Location:4 → 427

PRK00885; phosphoribosylamine--glycine ligase; Provisional

PRK05385
Location:436 → 764

PRK05385; phosphoribosylaminoimidazole synthetase; Provisional

pfam01071
Location:105 → 298

GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain

pfam02843
Location:334 → 425

GARS_C; Phosphoribosylglycinamide synthetase, C domain

pfam02844
Location:4 → 104

GARS_N; Phosphoribosylglycinamide synthetase, N domain