badb BCL2 associated agonist of cell death b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: badbprovided by ZNC
Official Full Name: BCL2 associated agonist of cell death bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000616-1
See related: Ensembl:ENSDARG00000054937 AllianceGenome:ZFIN:ZDB-GENE-000616-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: bad; fa01b12; wu:fa01b12; wu:fa96d04
Summary: Acts upstream of or within cellular response to ionizing radiation and positive regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including brain; heart; hindbrain neural plate; midbrain hindbrain boundary neural keel; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in endometrial cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to human BAD (BCL2 associated agonist of cell death). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (25129520..25135758, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (24858363..24864601, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Proapoptotic Gene Bad Regulates Brain Development via p53-Mediated Stress Signals in Zebrafish.
Title: The Proapoptotic Gene Bad Regulates Brain Development via p53-Mediated Stress Signals in Zebrafish.
Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish.
Title: Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish.
Bad functions as an essential sensitizer and Puma as an essential activator of IR-induced mitochondrial apoptosis specifically in embryonic neural tissue.
Title: Interdependence of Bad and Puma during ionizing-radiation-induced apoptosis.
Stage-specific expression of TNFalpha regulates bad/bid-mediated apoptosis and RIP1/ROS-mediated secondary necrosis in Birnavirus-infected fish cells.
Title: Stage-specific expression of TNFα regulates bad/bid-mediated apoptosis and RIP1/ROS-mediated secondary necrosis in Birnavirus-infected fish cells.
Results indicate that zebrafish BH3-only proapoptotic protein (BAD) could induce apoptosis in vitro and in vivo and may have biological implications in apoptosis during zebrafish development.
Title: Cloning of zebrafish BAD, a BH3-only proapoptotic protein, whose overexpression leads to apoptosis in COS-1 cells and zebrafish embryos.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to ionizing radiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: BCL2 associated agonist of cell death b; BCL2-antagonist of cell death b

Names: proapoptotic BH3-only protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270595.1 → NP_001257524.1 BCL2 associated agonist of cell death b isoform 1

See identical proteins and their annotated locations for NP_001257524.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).

Source sequence(s)

AA495398, EH561412, EH592357

UniProtKB/TrEMBL

B2GR09, Q4V925

Related

ENSDARP00000071687.3, ENSDART00000077219.5

Conserved Domains (1) summary

pfam10514
Location:51 → 135

Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD
NM_131579.2 → NP_571654.1 BCL2 associated agonist of cell death b isoform 2

See identical proteins and their annotated locations for NP_571654.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AA495398, EH498043, EH561412

UniProtKB/TrEMBL

A0A8N1Z227, Q9I9N2

Related

ENSDARP00000106381.1, ENSDART00000121943.3

Conserved Domains (1) summary

pfam10514
Location:51 → 134

Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD