axin2 axin 2 (conductin, axil) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: axin2provided by ZNC
Official Full Name: axin 2 (conductin, axil)provided by ZNC
Primary source: ZFIN:ZDB-GENE-000403-2
See related: Ensembl:ENSDARG00000100149 AllianceGenome:ZFIN:ZDB-GENE-000403-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: axil; wu:fb37c08; zgc:111942
Summary: Involved in negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification. Acts upstream of or within dorsal/ventral axis specification and heart development. Predicted to be located in cytoplasm. Is expressed in several structures, including anterior neural keel; marginal blastomere; nervous system; pharyngeal arch; and pleuroperitoneal region. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in colorectal cancer and endometrial adenocarcinoma. Orthologous to human AXIN2 (axin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (55631128..55650725, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (55379519..55399116, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of WNT signaling restores the facial deficits in a zebrafish with defects in cholesterol metabolism.
Title: Activation of WNT signaling restores the facial deficits in a zebrafish with defects in cholesterol metabolism.
beta-catenin1 cannot revert the ich phenotype because it may be under the control of a GSK3beta-independent mechanism that required Axin's RGS domain function.
Title: The increase in maternal expression of axin1 and axin2 contribute to the zebrafish mutant ichabod ventralized phenotype.

Submit: New GeneRIF Correction

General gene information

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Markers

fb37c08.x1 (e-PCR)
- UniSTS:190513

fb37c08.x1 (e-PCR)
- UniSTS:190514

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables I-SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dorsal/ventral axis specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of centromeric sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of beta-catenin destruction complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: axin-2

Names: axis inhibition protein 2; etID37069.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131561.1 → NP_571636.1 axin-2

See identical proteins and their annotated locations for NP_571636.1

Status: PROVISIONAL

Source sequence(s)

AB032263

UniProtKB/Swiss-Prot

P57095, Q335M5

Related

ENSDARP00000132477.1, ENSDART00000162413.2

Conserved Domains (4) summary

cd08707
Location:85 → 201

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

pfam00778
Location:732 → 807

DIX; DIX domain

pfam08833
Location:429 → 464

Axin_b-cat_bind; Axin beta-catenin binding domain

pfam16646
Location:5 → 76

AXIN1_TNKS_BD; Axin-1 tankyrase binding domain