fzd8a frizzled class receptor 8a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fzd8aprovided by ZNC
Official Full Name: frizzled class receptor 8aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000328-3
See related: Ensembl:ENSDARG00000045444 AllianceGenome:ZFIN:ZDB-GENE-000328-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fz5; fzc; fz8a; zg05; wu:fd02c05
Summary: Predicted to enable Wnt-activated receptor activity and Wnt-protein binding activity. Acts upstream of or within canonical Wnt signaling pathway; eye field cell fate commitment involved in camera-type eye formation; and neurogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including digestive system; mesoderm; nervous system; neural keel; and pectoral fin. Orthologous to human FZD8 (frizzled class receptor 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (4447634..4450238, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (4415847..4418451, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that Frizzled8a plays a specific role in regulating cell cycle progression during the differentiation of retinal progenitor cells.
Title: Mutation of frizzled8a delays neural retinal cell differentiation and results in microphthalmia in zebrafish.
fzd8a is expressed in the pharyngeal endoderm.
Title: Expression of five frizzleds during zebrafish craniofacial development.
These results demonstrated that overexpression of DNfz8a in Zoep embryos between 7 and 16hpf increased putative forebrain region demarcated by anf and distal-less2 expressions.
Title: Normal forebrain development may require continual Wnt antagonism until mid-somitogenesis in zebrafish.
Fz8a plays a critical role in the specification and maturation of oligodendrocyte progenitor cells (OPCs) in the ventral spinal cord.
Title: Frizzled 8a function is required for oligodendrocyte development in the zebrafish spinal cord.
Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish.
Title: Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish.
wnt11 and Fz5 signaling promotes early eye development through the coordinated antagonism of signals that suppress retinal identity
Title: Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fd02c05.x1 (e-PCR)
- UniSTS:204043

AF060697 (e-PCR)
- UniSTS:205627

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within eye field cell fate commitment involved in camera-type eye formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spinal cord oligodendrocyte cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord radial glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: frizzled-8a

Names: frizzled homolog 8a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130918.2 → NP_570993.2 frizzled-8a precursor

See identical proteins and their annotated locations for NP_570993.2

Status: PROVISIONAL

Source sequence(s)

BC056273

UniProtKB/TrEMBL

Q6P4V8, Q9YI00

Related

ENSDARP00000066834.4, ENSDART00000066835.6

Conserved Domains (2) summary

cd07461
Location:26 → 150

CRD_FZ8; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 8 (Fz8) receptor

cd15250
Location:228 → 537

7tmF_FZD8; class F frizzled subfamily 8, member of 7-transmembrane G protein-coupled receptors