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pcxb pyruvate carboxylase b [ Danio rerio (zebrafish) ]

Gene ID: 58068, updated on 27-Mar-2024

Summary

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Official Symbol
pcxbprovided by ZNC
Official Full Name
pyruvate carboxylase bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-000831-1
See related
Ensembl:ENSDARG00000051939 AllianceGenome:ZFIN:ZDB-GENE-000831-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pc; pyc; PYCb; wu:fb82g08; wu:fj85g01
Summary
Predicted to enable pyruvate carboxylase activity. Acts upstream of or within response to cadmium ion. Predicted to be active in cytoplasm. Is expressed in brain; gill; liver; and musculature system. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See pcxb in Genome Data Viewer
Location:
chromosome: 7
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (60457138..60831082, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (60151901..60525845, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14Bb Neighboring gene BRMS1 transcriptional repressor and anoikis regulator Neighboring gene uncharacterized LOC110439982 Neighboring gene leucine-rich repeat and fibronectin type-III domain-containing protein 4-like Neighboring gene leucine rich repeat and fibronectin type III domain containing 4b Neighboring gene uncharacterized LOC103911428 Neighboring gene uncharacterized LOC110439981

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish fth1, slc3a2, men1, pc, fgf3 and cycd1 genes define two regions of conserved synteny between linkage group 7 and human chromosome 11q13. Yoder JA, et al. Gene, 2000 Dec 31. PMID 11167010
  2. Profiling hepatic microRNAs in zebrafish: fluoxetine exposure mimics a fasting response that targets AMP-activated protein kinase (AMPK). Craig PM, et al. PLoS One, 2014. PMID 24751937, Free PMC Article
  3. In silico and biological analysis of anti-androgen activity of the brominated flame retardants ATE, BATE and DPTE in zebrafish. Pradhan A, et al. Chem Biol Interact, 2015 May 25. PMID 25818047
  4. Conservation of the Nrf2-Mediated Gene Regulation of Proteasome Subunits and Glucose Metabolism in Zebrafish. Nguyen VT, et al. Oxid Med Cell Longev, 2016. PMID 28116036, Free PMC Article
  5. Comparative effects of dietary methylmercury on gene expression in liver, skeletal muscle, and brain of the zebrafish (Danio rerio). Gonzalez P, et al. Environ Sci Technol, 2005 Jun 1. PMID 15984772

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pyruvate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to cadmium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pyruvate carboxylase, mitochondrial
NP_571625.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131550.2 → NP_571625.2  pyruvate carboxylase, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    BX284674, BX294163, BX470085, CT030203, EB794119, EH595604, EH613146
    UniProtKB/TrEMBL
    A0A8N7UZL1, F1QYZ6
    Related
    ENSDARP00000068144.2, ENSDART00000073654.4
    Conserved Domains (7) summary
    cd06850
    Location:1113 → 1179
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:567 → 850
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:377 → 484
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    PRK12999
    Location:38 → 1179
    PRK12999; pyruvate carboxylase; Reviewed
    pfam00289
    Location:39 → 147
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:863 → 1062
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:153 → 360
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    60457138..60831082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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