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Pidd1 p53 induced death domain protein 1 [ Mus musculus (house mouse) ]

Gene ID: 57913, updated on 16-Apr-2024

Summary

Official Symbol
Pidd1provided by MGI
Official Full Name
p53 induced death domain protein 1provided by MGI
Primary source
MGI:MGI:1889507
See related
Ensembl:ENSMUSG00000025507 AllianceGenome:MGI:1889507
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrdd; Pidd; 1200011D09Rik
Summary
Predicted to enable endopeptidase activity. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process and extrinsic apoptotic signaling pathway via death domain receptors. Located in cytoplasm. Is expressed in brain; liver; nose; and urinary system. Orthologous to human PIDD1 (p53-induced death domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 13.9), liver E14.5 (RPKM 6.5) and 23 other tissues See more
Orthologs
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Genomic context

See Pidd1 in Genome Data Viewer
Location:
7 F5; 7 86.79 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141018026..141027477, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141438113..141447565, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cell cycle exit and neuronal differentiation 1 Neighboring gene solute carrier family 25 (mitochondrial carrier, glutamate), member 22 Neighboring gene STARR-positive B cell enhancer ABC_E4986 Neighboring gene STARR-positive B cell enhancer ABC_E1097 Neighboring gene ribosomal protein lateral stalk subunit P2 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene STARR-positive B cell enhancer ABC_E9305 Neighboring gene patatin-like phospholipase domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein autoprocessing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of endopeptidase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
p53-induced death domain-containing protein 1
Names
leucine-rich and death domain containing
leucine-rich repeat and death domain-containing protein
p53 protein induced, with death domain
p53-induced protein with a death domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360523.1NP_001347452.1  p53-induced death domain-containing protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (a).
    Source sequence(s)
    AC158224, BC145314
    Related
    ENSMUST00000131980.8
    Conserved Domains (3) summary
    cd08779
    Location:475560
    Death_PIDD; Death Domain of p53-induced protein with a death domain
    pfam10461
    Location:108140
    Peptidase_S68; Peptidase S68
    cl02517
    Location:1285
    ZU5; ZU5 domain
  2. NM_001360524.1NP_001347453.1  p53-induced death domain-containing protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (a).
    Source sequence(s)
    AC158224, BC089373
    Related
    ENSMUST00000147268.8
    Conserved Domains (3) summary
    cd08779
    Location:475560
    Death_PIDD; Death Domain of p53-induced protein with a death domain
    pfam10461
    Location:108140
    Peptidase_S68; Peptidase S68
    cl02517
    Location:1285
    ZU5; ZU5 domain
  3. NM_022654.2NP_073145.1  p53-induced death domain-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_073145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC158224
    Consensus CDS
    CCDS22014.1
    UniProtKB/Swiss-Prot
    A6H6F4, Q9ERV7
    Related
    ENSMUSP00000026580.6, ENSMUST00000026580.12
    Conserved Domains (6) summary
    cd00116
    Location:132295
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:132154
    LRR_RI; leucine-rich repeat [structural motif]
    pfam10461
    Location:426458
    Peptidase_S68; Peptidase S68
    pfam13855
    Location:222280
    LRR_8; Leucine rich repeat
    cl02517
    Location:330403
    ZU5; ZU5 domain
    cl14633
    Location:793878
    DD; Death Domain Superfamily of protein-protein interaction domains

RNA

  1. NR_153591.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC158224
    Related
    ENSMUST00000128703.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141018026..141027477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153304.1XP_036009197.1  p53-induced death domain-containing protein 1 isoform X2

    Conserved Domains (3) summary
    cd08779
    Location:475560
    Death_PIDD; Death Domain of p53-induced protein with a death domain
    pfam10461
    Location:108140
    Peptidase_S68; Peptidase S68
    cl02517
    Location:1285
    ZU5; ZU5 domain
  2. XM_011249849.4XP_011248151.1  p53-induced death domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011248151.1

    Conserved Domains (4) summary
    COG4886
    Location:126285
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:132154
    LRR_RI; leucine-rich repeat [structural motif]
    pfam10461
    Location:426458
    Peptidase_S68; Peptidase S68
    cl02517
    Location:330403
    ZU5; ZU5 domain

RNA

  1. XR_001785592.3 RNA Sequence

  2. XR_389958.5 RNA Sequence

  3. XR_004934157.1 RNA Sequence