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Tnip1 TNFAIP3 interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 57783, updated on 5-Mar-2024

Summary

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Official Symbol
Tnip1provided by MGI
Official Full Name
TNFAIP3 interacting protein 1provided by MGI
Primary source
MGI:MGI:1926194
See related
Ensembl:ENSMUSG00000020400 AllianceGenome:MGI:1926194
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nef; VAN; ABIN; Naf1; ABIN1; ABIN-1
Summary
Enables polyubiquitin modification-dependent protein binding activity. Involved in several processes, including MyD88-dependent toll-like receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of inflammatory response. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human TNIP1 (TNFAIP3 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 26.8), duodenum adult (RPKM 23.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 32.13 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54801613..54853766, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54910787..54962956, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1343 Neighboring gene histidine triad nucleotide binding protein 1 Neighboring gene glutathione peroxidase 3 Neighboring gene STARR-positive B cell enhancer ABC_E11481 Neighboring gene STARR-positive B cell enhancer ABC_E1824 Neighboring gene 40S ribosomal protein S11-like Neighboring gene STARR-seq mESC enhancer starr_29522 Neighboring gene STARR-seq mESC enhancer starr_29523 Neighboring gene annexin A6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:54836566-54836859 Neighboring gene predicted gene, 19911 Neighboring gene coiled-coil domain containing 69

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice. Nanda SK, et al. Life Sci Alliance, 2019 Dec. PMID 31694920, Free PMC Article
  2. Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function. Ippagunta SK, et al. Proc Natl Acad Sci U S A, 2016 Oct 11. PMID 27671649, Free PMC Article
  3. An important role for A20-binding inhibitor of nuclear factor-kB-1 (ABIN1) in inflammation-mediated endothelial dysfunction: an in vivo study in ABIN1 (D485N) mice. Akbar N, et al. Arthritis Res Ther, 2015 Feb 4. PMID 25648164, Free PMC Article
  4. Adenoviral gene transfer of the NF-kappa B inhibitory protein ABIN-1 decreases allergic airway inflammation in a murine asthma model. El Bakkouri K, et al. J Biol Chem, 2005 May 6. PMID 15722346
  5. ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis. Bao J, et al. Genet Res (Camb), 2022. PMID 36034412, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression.
    Title: ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression.
  2. ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis.
    Title: ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis.
  3. ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer.
    Title: ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer.
  4. A20-Binding Inhibitor of Nuclear Factor-kappaB Targets beta-Arrestin2 to Attenuate Opioid Tolerance.
    Title: A20-Binding Inhibitor of Nuclear Factor-κB Targets β-Arrestin2 to Attenuate Opioid Tolerance.
  5. The ABIN-1 heterozygosity sensitizes innate immune response of Abin-1(+/)(-) mice in vivo by promoting the production of proinflammatory cytokines, which can be blocked upon inhibition of RIPK1 kinase.
    Title: ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.
  6. The splenic iMo of ABIN1[D485N] mice displayed high expression of mRNAs encoding proteins controlling cell division and were actively dividing; this may underlie the increased pMo and MoDC numbers, which are derived from iMo.
    Title: Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice.
  7. These data show that the disease susceptibility proteins A20 and ABIN-1 synergistically prevent intestinal inflammation by restricting IEC death and preserving tissue integrity.
    Title: A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival.
  8. It has been proposed that ABIN-1 provides a critical link between methionine1 ubiquitylation mediated by the LUBAC complex and lysine63 deubiquitylation by phospho-A20 to modulate the activation of RIPK1.
    Title: ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC.
  9. Reduced expression of TNIP1 was determined in hepatic ischemia/reperfusion (I/R) injury compared to normal mice. Then, TNIP1 transgene mice were used to determine the effects of TNIP1 on mice after treatment for I/R.
    Title: TNIP1 alleviates hepatic ischemia/reperfusion injury via the TLR2-Myd88 pathway.
  10. the data establish Tnip1 as a critical regulator of IL-17 biology and reveal a causal role of keratinocytes in the pathogenesis of psoriasis.
    Title: Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (7)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TNFAIP3-interacting protein 1
Names
A20-binding inhibitor of NF-kappa B activation
Nef-associated factor 1
virion-associated nuclear shuttling protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199275.2 → NP_001186204.1  TNFAIP3-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001186204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AL593846
    Consensus CDS
    CCDS24704.1
    UniProtKB/Swiss-Prot
    Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
    UniProtKB/TrEMBL
    E9QM75
    Related
    ENSMUSP00000099792.2, ENSMUST00000102731.8
    Conserved Domains (2) summary
    COG1196
    Location:311 → 542
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:227 → 264
    MreC; rod shape-determining protein MreC

  2. NM_001199276.2 → NP_001186205.1  TNFAIP3-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001186205.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AL593846
    Consensus CDS
    CCDS56769.1
    UniProtKB/Swiss-Prot
    Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
    Related
    ENSMUSP00000104514.2, ENSMUST00000108886.8
    Conserved Domains (2) summary
    COG1196
    Location:258 → 489
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:174 → 211
    MreC; rod shape-determining protein MreC

  3. NM_001271455.1 → NP_001258384.1  TNFAIP3-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001258384.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AL593846
    Consensus CDS
    CCDS56769.1
    UniProtKB/Swiss-Prot
    Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
    Related
    ENSMUSP00000104513.2, ENSMUST00000108885.8
    Conserved Domains (2) summary
    COG1196
    Location:258 → 489
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:174 → 211
    MreC; rod shape-determining protein MreC

  4. NM_001271456.1 → NP_001258385.1  TNFAIP3-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001258385.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL593846
    Consensus CDS
    CCDS70188.1
    UniProtKB/Swiss-Prot
    Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
    UniProtKB/TrEMBL
    D3Z2W0
    Related
    ENSMUSP00000099791.3, ENSMUST00000102730.9
    Conserved Domains (2) summary
    COG1196
    Location:311 → 542
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:227 → 264
    MreC; rod shape-determining protein MreC

  5. NM_021327.4 → NP_067302.2  TNFAIP3-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_067302.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AL593846
    Consensus CDS
    CCDS24704.1
    UniProtKB/Swiss-Prot
    Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
    UniProtKB/TrEMBL
    E9QM75
    Related
    ENSMUSP00000018482.7, ENSMUST00000018482.13
    Conserved Domains (2) summary
    COG1196
    Location:311 → 542
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:227 → 264
    MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    54801613..54853766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249162.1 → XP_011247464.1  TNFAIP3-interacting protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011247464.1

    UniProtKB/Swiss-Prot
    Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
    UniProtKB/TrEMBL
    D3Z2W0
    Conserved Domains (2) summary
    COG1196
    Location:311 → 542
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:227 → 264
    MreC; rod shape-determining protein MreC

  2. XM_030246197.2 → XP_030102057.1  TNFAIP3-interacting protein 1 isoform X4

    UniProtKB/Swiss-Prot
    Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
    Conserved Domains (2) summary
    COG1196
    Location:258 → 489
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:174 → 211
    MreC; rod shape-determining protein MreC

  3. XM_011249163.4 → XP_011247465.1  TNFAIP3-interacting protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011247465.1

    UniProtKB/Swiss-Prot
    Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
    Conserved Domains (2) summary
    COG1196
    Location:258 → 489
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:174 → 211
    MreC; rod shape-determining protein MreC

  4. XM_030246199.1 → XP_030102059.1  TNFAIP3-interacting protein 1 isoform X6

    UniProtKB/Swiss-Prot
    Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
    Conserved Domains (2) summary
    COG1196
    Location:225 → 456
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:141 → 178
    MreC; rod shape-determining protein MreC

  5. XM_006533848.3 → XP_006533911.1  TNFAIP3-interacting protein 1 isoform X5

    See identical proteins and their annotated locations for XP_006533911.1

    UniProtKB/Swiss-Prot
    Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
    Conserved Domains (2) summary
    COG1196
    Location:225 → 456
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:141 → 178
    MreC; rod shape-determining protein MreC

  6. XM_011249164.3 → XP_011247466.1  TNFAIP3-interacting protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011247466.1

    UniProtKB/Swiss-Prot
    Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
    Conserved Domains (2) summary
    COG1196
    Location:225 → 456
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:141 → 178
    MreC; rod shape-determining protein MreC

  7. XM_006533847.5 → XP_006533910.1  TNFAIP3-interacting protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006533910.1

    UniProtKB/Swiss-Prot
    Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
    Conserved Domains (2) summary
    COG1196
    Location:258 → 489
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:174 → 211
    MreC; rod shape-determining protein MreC

  8. XM_030246196.2 → XP_030102056.1  TNFAIP3-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
    UniProtKB/TrEMBL
    D3Z2W0
    Conserved Domains (2) summary
    COG1196
    Location:311 → 542
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:227 → 264
    MreC; rod shape-determining protein MreC

  9. XM_006533846.5 → XP_006533909.1  TNFAIP3-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006533909.1

    UniProtKB/Swiss-Prot
    Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
    UniProtKB/TrEMBL
    E9QM75
    Related
    ENSMUSP00000104517.4, ENSMUST00000108889.10
    Conserved Domains (2) summary
    COG1196
    Location:311 → 542
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:227 → 264
    MreC; rod shape-determining protein MreC
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUU8.1 GenPept UniProtKB/Swiss-Prot:Q9WUU8

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