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Rnf25 ring finger protein 25 [ Mus musculus (house mouse) ]

Gene ID: 57751, updated on 5-Mar-2024

Summary

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Official Symbol
Rnf25provided by MGI
Official Full Name
ring finger protein 25provided by MGI
Primary source
MGI:MGI:1890215
See related
Ensembl:ENSMUSG00000026171 AllianceGenome:MGI:1890215
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AO7; 0610009H16Rik
Summary
Enables ubiquitin protein ligase activity. Involved in protein ubiquitination. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human RNF25 (ring finger protein 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 37.6), limb E14.5 (RPKM 24.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf25 in Genome Data Viewer
Location:
1 C4; 1 38.54 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74632907..74640556, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74593748..74601397, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 142 Neighboring gene STARR-seq mESC enhancer starr_01339 Neighboring gene STARR-positive B cell enhancer ABC_E791 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Neighboring gene serine/threonine kinase 36 Neighboring gene STARR-seq mESC enhancer starr_01341 Neighboring gene tubulin tyrosine ligase-like family, member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit. Asamitsu K, et al. J Biol Chem, 2003 Jul 18. PMID 12748188
  2. EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. Ding W, et al. Proc Natl Acad Sci U S A, 2008 Sep 9. PMID 18757723, Free PMC Article
  3. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Lorick KL, et al. Proc Natl Acad Sci U S A, 1999 Sep 28. PMID 10500182, Free PMC Article
  4. Global gene expression analysis of murine limb development. Taher L, et al. PLoS One, 2011. PMID 22174793, Free PMC Article
  5. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identify an EGFR-independent action of TGF-alpha, in which it protects Naked2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells
    Title: EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.
  2. RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit.
    Title: RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K6-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF25
Names
RING finger protein AO7
RING-type E3 ubiquitin transferase RNF25
NP_001292159.1
NP_067288.2
XP_006496233.1
XP_030111555.1
XP_036008396.1
XP_036008397.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305230.1 → NP_001292159.1  E3 ubiquitin-protein ligase RNF25 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant (1). The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC117610, AK002399, AK011171, BG081026, BP774070
    Consensus CDS
    CCDS78620.1
    UniProtKB/TrEMBL
    E9Q446
    Related
    ENSMUSP00000109350.2, ENSMUST00000113721.8
    Conserved Domains (2) summary
    smart00591
    Location:19 → 127
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam13639
    Location:132 → 198
    zf-RING_2; Ring finger domain

  2. NM_021313.3 → NP_067288.2  E3 ubiquitin-protein ligase RNF25 isoform 1

    See identical proteins and their annotated locations for NP_067288.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC117610, AK002399, BE853767, BP774070
    Consensus CDS
    CCDS15052.1
    UniProtKB/Swiss-Prot
    Q3TAL8, Q9DCW7, Q9QZR0
    Related
    ENSMUSP00000027357.6, ENSMUST00000027357.12
    Conserved Domains (2) summary
    smart00591
    Location:19 → 127
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam13639
    Location:132 → 199
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74632907..74640556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152504.1 → XP_036008397.1  E3 ubiquitin-protein ligase RNF25 isoform X4

    Conserved Domains (1) summary
    cd16470
    Location:22 → 88
    RING-H2_RNF25; RING finger, H2 subclass, found in RING finger protein 25 (RNF25) and similar proteins

  2. XM_036152503.1 → XP_036008396.1  E3 ubiquitin-protein ligase RNF25 isoform X3

    Conserved Domains (1) summary
    cd16470
    Location:22 → 89
    RING-H2_RNF25; RING finger, H2 subclass, found in RING finger protein 25 (RNF25) and similar proteins

  3. XM_030255695.2 → XP_030111555.1  E3 ubiquitin-protein ligase RNF25 isoform X2

    Conserved Domains (2) summary
    smart00591
    Location:6 → 94
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    cd16470
    Location:100 → 166
    RING-H2_RNF25; RING finger, H2 subclass, found in RING finger protein 25 (RNF25) and similar proteins

  4. XM_006496170.3 → XP_006496233.1  E3 ubiquitin-protein ligase RNF25 isoform X1

    Conserved Domains (2) summary
    smart00591
    Location:6 → 94
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    cd16470
    Location:100 → 167
    RING-H2_RNF25; RING finger, H2 subclass, found in RING finger protein 25 (RNF25) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZR0.2 GenPept UniProtKB/Swiss-Prot:Q9QZR0

Gene LinkOut

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