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USP29 ubiquitin specific peptidase 29 [ Homo sapiens (human) ]

Gene ID: 57663, updated on 4-Jan-2025

Summary

Official Symbol
USP29provided by HGNC
Official Full Name
ubiquitin specific peptidase 29provided by HGNC
Primary source
HGNC:HGNC:18563
See related
Ensembl:ENSG00000131864 MIM:609546; AllianceGenome:HGNC:18563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOM-TES-84/86
Summary
Predicted to enable cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of type I interferon-mediated signaling pathway; and protein K48-linked deubiquitination. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward testis (RPKM 2.8) See more
Orthologs
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Genomic context

See USP29 in Genome Data Viewer
Location:
19q13.43
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57119087..57131926)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60215749..60228591)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57630455..57643294)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372475 Neighboring gene Sharpr-MPRA regulatory region 3098 Neighboring gene zinc finger protein 300 pseudogene Neighboring gene small nucleolar RNA U3 Neighboring gene zinc finger imprinted 3 Neighboring gene DPPA3 pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Clone Names

  • MGC163266, MGC163270

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity  
enables cysteine-type deubiquitinase activity PubMed 
enables cysteine-type endopeptidase activity  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle  
involved_in defense response to virus  
involved_in innate immune response  
involved_in positive regulation of type I interferon-mediated signaling pathway  
involved_in protein K48-linked deubiquitination  
involved_in protein stabilization  
involved_in proteolysis  
involved_in regulation of protein stability  
Component Evidence Code Pubs
is_active_in cytosol  
is_active_in nucleus  
located_in perinuclear region of cytoplasm  

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 29
Names
deubiquitinating enzyme 29
ubiquitin thioesterase 29
ubiquitin thiolesterase 29
ubiquitin-specific processing protease
ubiquitin-specific-processing protease 29
NP_001376572.1
NP_001413334.1
NP_001413335.1
NP_065954.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389643.1NP_001376572.1  ubiquitin carboxyl-terminal hydrolase 29 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC025588
    Consensus CDS
    CCDS33124.1
    UniProtKB/Swiss-Prot
    Q9HBJ7
    Related
    ENSP00000470747.1, ENST00000598197.1
    Conserved Domains (3) summary
    cd02257
    Location:823883
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cd13312
    Location:4106
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:286552
    UCH; Ubiquitin carboxyl-terminal hydrolase
  2. NM_001426405.1NP_001413334.1  ubiquitin carboxyl-terminal hydrolase 29 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CP068259
    UniProtKB/TrEMBL
    A1L447
  3. NM_001426406.1NP_001413335.1  ubiquitin carboxyl-terminal hydrolase 29 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CP068259
    UniProtKB/TrEMBL
    A1L447
  4. NM_020903.3NP_065954.1  ubiquitin carboxyl-terminal hydrolase 29 isoform 1

    See identical proteins and their annotated locations for NP_065954.1

    Status: VALIDATED

    Source sequence(s)
    AC025588
    Consensus CDS
    CCDS33124.1
    UniProtKB/Swiss-Prot
    Q9HBJ7
    Related
    ENSP00000254181.3, ENST00000254181.9
    Conserved Domains (3) summary
    cd02257
    Location:823883
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cd13312
    Location:4106
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:286552
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57119087..57131926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60215749..60228591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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