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fynb FYN proto-oncogene, Src family tyrosine kinase b [ Danio rerio (zebrafish) ]

Gene ID: 574422, updated on 11-Apr-2024

Summary

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Official Symbol
fynbprovided by ZNC
Official Full Name
FYN proto-oncogene, Src family tyrosine kinase bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050706-89
See related
Ensembl:ENSDARG00000025319 AllianceGenome:ZFIN:ZDB-GENE-050706-89
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:6908851; zgc:109996; si:dkey-119m7.5
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Acts upstream of or within convergent extension involved in gastrulation; fin regeneration; and regulation of protein kinase activity. Predicted to be located in cytoplasm. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in caudal fin. Human ortholog(s) of this gene implicated in Alzheimer's disease and schizophrenia. Orthologous to human FYN (FYN proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See fynb in Genome Data Viewer
Location:
chromosome: 20
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (328942..397237)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (340308..408303)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene tubulin, epsilon 1 Neighboring gene cellular communication network factor 6 Neighboring gene si:dkey-119m7.4 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4 Neighboring gene G protein-coupled receptor 63

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Protein-tyrosine kinase activity profiling in knock down zebrafish embryos. Lemeer S, et al. PLoS One, 2007 Jul 4. PMID 17611617, Free PMC Article
  2. Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish. Yoo SK, et al. J Cell Biol, 2012 Oct 15. PMID 23045550, Free PMC Article
  3. Fyn/Yes and non-canonical Wnt signalling converge on RhoA in vertebrate gastrulation cell movements. Jopling C, et al. EMBO Rep, 2005 May. PMID 15815683, Free PMC Article
  4. In vivo Host-Pathogen Interaction as Revealed by Global Proteomic Profiling of Zebrafish Larvae. Díaz-Pascual F, et al. Front Cell Infect Microbiol, 2017. PMID 28791256, Free PMC Article
  5. Comparative phosphoproteomics of zebrafish Fyn/Yes morpholino knockdown embryos. Lemeer S, et al. Mol Cell Proteomics, 2008 Nov. PMID 18550893

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within convergent extension involved in gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within fin regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of protein kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase fynb
Names
FYN oncogene related to SRC, FGR, YES b
proto-oncogene c-Fynb
NP_001025140.1
XP_005160359.1
XP_009292762.1
XP_021324187.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029969.1 → NP_001025140.1  tyrosine-protein kinase fynb

    See identical proteins and their annotated locations for NP_001025140.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098534
    UniProtKB/Swiss-Prot
    F1RDG9
    Related
    ENSDARP00000037198.7, ENSDART00000036635.8
    Conserved Domains (4) summary
    cd10418
    Location:152 → 252
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:92 → 147
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:278 → 527
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:268 → 541
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    328942..397237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160302.4 → XP_005160359.1  tyrosine-protein kinase fynb isoform X1

    See identical proteins and their annotated locations for XP_005160359.1

    UniProtKB/Swiss-Prot
    F1RDG9, Q4KMJ8
    UniProtKB/TrEMBL
    A0A8M9P2R3
    Related
    ENSDARP00000133954.1, ENSDART00000169407.2
    Conserved Domains (3) summary
    cd10418
    Location:152 → 252
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:92 → 147
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cl21453
    Location:268 → 541
    PKc_like; Protein Kinases, catalytic domain

  2. XM_009294487.3 → XP_009292762.1  tyrosine-protein kinase fynb isoform X2

    UniProtKB/TrEMBL
    A0A8M3AKJ9
    Conserved Domains (4) summary
    cd12006
    Location:92 → 147
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    pfam07714
    Location:238 → 472
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:152 → 252
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:238 → 474
    PKc_like; Protein Kinases, catalytic domain

  3. XM_021468512.1 → XP_021324187.1  tyrosine-protein kinase fynb isoform X1

    UniProtKB/Swiss-Prot
    F1RDG9, Q4KMJ8
    UniProtKB/TrEMBL
    A0A8M9P2R3
    Conserved Domains (3) summary
    cd10418
    Location:152 → 252
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:92 → 147
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cl21453
    Location:268 → 541
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1RDG9.1 GenPept UniProtKB/Swiss-Prot:F1RDG9

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