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P2ry4 pyrimidinergic receptor P2Y, G-protein coupled, 4 [ Mus musculus (house mouse) ]

Gene ID: 57385, updated on 2-May-2024

Summary

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Official Symbol
P2ry4provided by MGI
Official Full Name
pyrimidinergic receptor P2Y, G-protein coupled, 4provided by MGI
Primary source
MGI:MGI:1926594
See related
Ensembl:ENSMUSG00000044359 AllianceGenome:MGI:1926594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P2Y4; P2Y4R
Summary
Enables G protein-coupled UTP receptor activity. Acts upstream of or within cellular response to prostaglandin E stimulus and transepithelial chloride transport. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Is expressed in skeletal muscle. Orthologous to human P2RY4 (pyrimidinergic receptor P2Y4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 7.1), large intestine adult (RPKM 3.5) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X C3; X 43.72 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (99631964..99638533, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (100588358..100594927, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene diacylglycerol O-acyltransferase 2-like 6 Neighboring gene acyl-CoA wax alcohol acyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_47635 Neighboring gene arrestin 3, retinal Neighboring gene PDZ domain containing 11 Neighboring gene kinesin family member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse P2Y(4) Nucleotide Receptor Is a Negative Regulator of Cardiac Adipose-Derived Stem Cell Differentiation and Cardiac Fat Formation. Lemaire A, et al. Stem Cells Dev, 2017 Mar 1. PMID 27855539
  2. Loss of mouse P2Y4 nucleotide receptor protects against myocardial infarction through endothelin-1 downregulation. Horckmans M, et al. J Immunol, 2015 Feb 15. PMID 25595790
  3. P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia. Li HQ, et al. Mol Cell Biol, 2013 Nov. PMID 24001770, Free PMC Article
  4. Gene deletion of P2Y4 receptor lowers exercise capacity and reduces myocardial hypertrophy with swimming exercise. Horckmans M, et al. Am J Physiol Heart Circ Physiol, 2012 Oct 1. PMID 22865387
  5. P2Y(4) nucleotide receptor: a novel actor in post-natal cardiac development. Horckmans M, et al. Angiogenesis, 2012 Sep. PMID 22437266

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Central role of PD-L1 in cardioprotection resulting from P2Y4 nucleotide receptor loss.
    Title: Central role of PD-L1 in cardioprotection resulting from P2Y(4) nucleotide receptor loss.
  2. These data highlight the P2Y4 receptor as an inhibitor of cardiac fat formation
    Title: Mouse P2Y(4) Nucleotide Receptor Is a Negative Regulator of Cardiac Adipose-Derived Stem Cell Differentiation and Cardiac Fat Formation.
  3. In the brain samples, expressions of P2Y4 and P2X7 were significantly reduced, whereas that of P2Y1 was significantly elevated in an age-dependent manner.
    Title: Viability of SH-SY5Y cells is associated with purinergic P2 receptor expression alterations.
  4. Data show that activation of nucleotide receptor P2Y4 (P2Y4) in the differentiating embryonic stem cells (ESCs) resulted in an increased proportion of neurons expressing vesicular glutamate transporter (vGluT).
    Title: P2Y4 Nucleotide Receptor in Neuronal Precursors Induces Glutamatergic Subtype Markers in Their Descendant Neurons.
  5. present study defines the P2Y4 nucleotide receptor, expressed on cardiac microvascular endothelial cells and involved in postnatal heart development, as an important regulator of the inflammatory response to cardiac ischemia
    Title: Loss of mouse P2Y4 nucleotide receptor protects against myocardial infarction through endothelin-1 downregulation.
  6. Amyloid beta peptide 1-42 induced self-uptake in microglia through pinocytosis, a process involving activation of P2Y4 receptors by autocrine ATP signaling.
    Title: P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia.
  7. P2Y(4) receptor could constitute an important regulator of acute and chronic response to exercise.
    Title: Gene deletion of P2Y4 receptor lowers exercise capacity and reduces myocardial hypertrophy with swimming exercise.
  8. study uncovers mouse P2Y(4) receptor as an essential regulator of cardiac endothelial cell function, and illustrates the involvement of endothelial-cardiomyocyte interactions in post-natal heart development
    Title: P2Y(4) nucleotide receptor: a novel actor in post-natal cardiac development.
  9. Purinergic receptors might represent important new set of molecular targets for theca hyperplasia and polycystic ovarian syndrome.
    Title: Functional expression and intracellular signaling of UTP-sensitive P2Y receptors in theca-interstitial cells.
  10. AQP2-mediated water transport is downregulated not only by basolateral nucleotides, mediated by P2Y(2) receptors, but also by luminal nucleotides, mediated by P2X(2) and/or P2Y(4) receptors.
    Title: Nucleotides downregulate aquaporin 2 via activation of apical P2 receptors.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled UTP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled UTP receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled purinergic nucleotide receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables pyrimidine nucleotide binding IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to prostaglandin E stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of presynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transepithelial chloride transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
P2Y purinoceptor 4
Names
P2Y4 receptor
purinergic receptor P2Y, G-protein coupled, 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020621.4 → NP_065646.1  P2Y purinoceptor 4

    See identical proteins and their annotated locations for NP_065646.1

    Status: VALIDATED

    Source sequence(s)
    AL671299
    Consensus CDS
    CCDS30303.1
    UniProtKB/Swiss-Prot
    Q9JJS7
    UniProtKB/TrEMBL
    Q0VBT7
    Related
    ENSMUSP00000055869.2, ENSMUST00000053373.2
    Conserved Domains (1) summary
    cd15374
    Location:32 → 313
    7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    99631964..99638533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528178.2 → XP_006528241.1  P2Y purinoceptor 4 isoform X1

    See identical proteins and their annotated locations for XP_006528241.1

    UniProtKB/Swiss-Prot
    Q9JJS7
    UniProtKB/TrEMBL
    Q0VBT7
    Conserved Domains (1) summary
    cd15374
    Location:32 → 313
    7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_006528175.2 → XP_006528238.1  P2Y purinoceptor 4 isoform X1

    See identical proteins and their annotated locations for XP_006528238.1

    UniProtKB/Swiss-Prot
    Q9JJS7
    UniProtKB/TrEMBL
    Q0VBT7
    Conserved Domains (1) summary
    cd15374
    Location:32 → 313
    7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_006528176.3 → XP_006528239.1  P2Y purinoceptor 4 isoform X1

    See identical proteins and their annotated locations for XP_006528239.1

    UniProtKB/Swiss-Prot
    Q9JJS7
    UniProtKB/TrEMBL
    Q0VBT7
    Conserved Domains (1) summary
    cd15374
    Location:32 → 313
    7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_006528177.2 → XP_006528240.1  P2Y purinoceptor 4 isoform X1

    See identical proteins and their annotated locations for XP_006528240.1

    UniProtKB/Swiss-Prot
    Q9JJS7
    UniProtKB/TrEMBL
    Q0VBT7
    Conserved Domains (1) summary
    cd15374
    Location:32 → 313
    7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJS7.1 GenPept UniProtKB/Swiss-Prot:Q9JJS7

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