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ndufs4 NADH:ubiquinone oxidoreductase subunit S4 [ Danio rerio (zebrafish) ]

Gene ID: 573689, updated on 27-Mar-2024

Summary

Official Symbol
ndufs4provided by ZNC
Official Full Name
NADH:ubiquinone oxidoreductase subunit S4provided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-421
See related
Ensembl:ENSDARG00000052840 AllianceGenome:ZFIN:ZDB-GENE-050522-421
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:112289
Summary
Predicted to enable oxidoreductase activity, acting on NAD(P)H. Predicted to act upstream of or within electron transport chain. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be part of mitochondrial respiratory chain complex I. Is expressed in brain; myotome; and pharyngeal arch 3-7. Human ortholog(s) of this gene implicated in Leigh disease and nuclear type mitochondrial complex I deficiency 1. Orthologous to human NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

Location:
chromosome: 5
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (40485530..40501732)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (39885377..39901579)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 15a Neighboring gene heat shock protein, alpha-crystallin-related, b3 Neighboring gene follistatin a Neighboring gene uncharacterized LOC103911097

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Clone Names

  • MGC112289

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within electron transport chain IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Names
NADH dehydrogenase (ubiquinone) Fe-S protein 4, (NADH-coenzyme Q reductase)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020676.1NP_001018512.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

    See identical proteins and their annotated locations for NP_001018512.1

    Status: PROVISIONAL

    Source sequence(s)
    BC095734
    UniProtKB/TrEMBL
    A5PMJ9, F6PF52, Q502E4
    Related
    ENSDARP00000051054.5, ENSDART00000051055.6
    Conserved Domains (1) summary
    pfam04800
    Location:69160
    ETC_C1_NDUFA4; ETC complex I subunit conserved region

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    40485530..40501732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394601.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    310589..326791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)