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Srsf4 serine and arginine-rich splicing factor 4 [ Mus musculus (house mouse) ]

Gene ID: 57317, updated on 21-Apr-2024

Summary

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Official Symbol
Srsf4provided by MGI
Official Full Name
serine and arginine-rich splicing factor 4provided by MGI
Primary source
MGI:MGI:1890577
See related
Ensembl:ENSMUSG00000028911 AllianceGenome:MGI:1890577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SRp75; Sfrs4; MNCb-2616; 5730499P16Rik
Summary
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 39.5), CNS E14 (RPKM 24.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.3; 4 64.53 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (131600841..131629036)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (131873530..131901725)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type U Neighboring gene predicted gene, 52680 Neighboring gene STARR-positive B cell enhancer ABC_E10262 Neighboring gene mitochondrial trans-2-enoyl-CoA reductase Neighboring gene predicted gene 12992 Neighboring gene phosphatidylinositol 3-kinase, catalytic, beta polypeptide pseudogene Neighboring gene transmembrane protein 200B Neighboring gene erythrocyte membrane protein band 4.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A. Yomoda J, et al. Genes Cells, 2008 Mar. PMID 18298798
  2. The SRSF4-GAS5-Glucocorticoid Receptor Axis Regulates Ventricular Hypertrophy. Larrasa-Alonso J, et al. Circ Res, 2021 Sep 3. PMID 34333993, Free PMC Article
  3. Androgen receptor binding to an androgen-responsive element in the promoter of the Srsf4 gene inhibits its expression in mouse Sertoli cells. Guo H, et al. Mol Reprod Dev, 2015 Dec. PMID 26308373
  4. The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes. Änkö ML, et al. Genome Biol, 2012. PMID 22436691, Free PMC Article
  5. Global analysis reveals SRp20- and SRp75-specific mRNPs in cycling and neural cells. Ankö ML, et al. Nat Struct Mol Biol, 2010 Aug. PMID 20639886

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The SRSF4-GAS5-Glucocorticoid Receptor Axis Regulates Ventricular Hypertrophy.
    Title: The SRSF4-GAS5-Glucocorticoid Receptor Axis Regulates Ventricular Hypertrophy.
  2. these results demonstrate that Srsf4 is a direct downstream target of the androgen receptor in mouse Sertoli cells.
    Title: Androgen receptor binding to an androgen-responsive element in the promoter of the Srsf4 gene inhibits its expression in mouse Sertoli cells.
  3. SRSF3 and SRSF4 proteins bind to the 3' ends of the majority of intronless histone transcripts, implicating SRSF3 and SRSF4 in histone mRNA metabolism.
    Title: The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes.
  4. mRNA targets of SRp20 and SRp75 were identified in cycling and neurally induced P19 cells.
    Title: Global analysis reveals SRp20- and SRp75-specific mRNPs in cycling and neural cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific mRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/arginine-rich splicing factor 4
Names
splicing factor, arginine/serine-rich 4 (SRp75)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369308.1 → NP_001356237.1  serine/arginine-rich splicing factor 4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AL607088
    Conserved Domains (3) summary
    cd12600
    Location:109 → 180
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    TIGR01642
    Location:250 → 361
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:42 → 77
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001369309.1 → NP_001356238.1  serine/arginine-rich splicing factor 4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AL607088
    Conserved Domains (3) summary
    cd12600
    Location:109 → 180
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    TIGR01642
    Location:250 → 361
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:42 → 77
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001369310.1 → NP_001356239.1  serine/arginine-rich splicing factor 4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AL607088
    Conserved Domains (3) summary
    cd12600
    Location:109 → 180
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    TIGR01642
    Location:250 → 361
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:42 → 77
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. NM_001369311.1 → NP_001356240.1  serine/arginine-rich splicing factor 4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AL607088
    Conserved Domains (3) summary
    cd12600
    Location:109 → 180
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    TIGR01642
    Location:250 → 361
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:42 → 77
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. NM_001369312.1 → NP_001356241.1  serine/arginine-rich splicing factor 4 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL607088
    Conserved Domains (2) summary
    cd12600
    Location:29 → 100
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    TIGR01642
    Location:170 → 281
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

  6. NM_020587.2 → NP_065612.2  serine/arginine-rich splicing factor 4 isoform b

    See identical proteins and their annotated locations for NP_065612.2

    Status: REVIEWED

    Source sequence(s)
    AK075769, AK077648, AV016063, BY107258
    Consensus CDS
    CCDS51315.1
    UniProtKB/TrEMBL
    Q542V3
    Related
    ENSMUSP00000061474.4, ENSMUST00000053819.6
    Conserved Domains (2) summary
    cd12337
    Location:3 → 72
    RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cd12600
    Location:104 → 175
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    131600841..131629036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320335.2 → XP_017175824.1  serine/arginine-rich splicing factor 4 isoform X2

    Conserved Domains (2) summary
    TIGR01642
    Location:122 → 234
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:1 → 52
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_036164281.1 → XP_036020174.1  serine/arginine-rich splicing factor 4 isoform X2

    Conserved Domains (2) summary
    TIGR01642
    Location:122 → 234
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:1 → 52
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_017320333.3 → XP_017175822.1  serine/arginine-rich splicing factor 4 isoform X1

    Conserved Domains (3) summary
    cd12600
    Location:109 → 180
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    TIGR01642
    Location:250 → 361
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:42 → 77
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_030253687.2 → XP_030109547.1  serine/arginine-rich splicing factor 4 isoform X2

    Conserved Domains (2) summary
    TIGR01642
    Location:122 → 234
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:1 → 52
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. XM_036164282.1 → XP_036020175.1  serine/arginine-rich splicing factor 4 isoform X2

    Conserved Domains (2) summary
    TIGR01642
    Location:122 → 234
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:1 → 52
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VE97.1 GenPept UniProtKB/Swiss-Prot:Q8VE97

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