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Rps27 ribosomal protein S27 [ Mus musculus (house mouse) ]

Gene ID: 57294, updated on 5-Mar-2024

Summary

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Official Symbol
Rps27provided by MGI
Official Full Name
ribosomal protein S27provided by MGI
Primary source
MGI:MGI:1888676
See related
Ensembl:ENSMUSG00000090733 AllianceGenome:MGI:1888676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3200001M24Rik
Summary
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in rRNA processing and ribosomal small subunit assembly. Predicted to be located in cytosolic ribosome and nucleus. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in postsynaptic density. Is expressed in central nervous system; pancreas epithelium; and retina. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 17. Orthologous to human RPS27 (ribosomal protein S27). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 517.3), limb E14.5 (RPKM 307.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 39.21 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90119974..90120955, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90212667..90213648, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene nucleoporin 210-like Neighboring gene predicted gene, 34865 Neighboring gene predicted gene, 23723 Neighboring gene STARR-seq mESC enhancer starr_08276 Neighboring gene predicted gene, 24185 Neighboring gene STARR-positive B cell enhancer ABC_E1624 Neighboring gene RAB13, member RAS oncogene family Neighboring gene jumping translocation breakpoint

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells. Mardaryev AN, et al. Development, 2014 Jan. PMID 24346698, Free PMC Article
  2. Comparative study of human and mouse postsynaptic proteomes finds high compositional conservation and abundance differences for key synaptic proteins. Bayés A, et al. PLoS One, 2012. PMID 23071613, Free PMC Article
  3. Protein NPM3 interacts with the multifunctional nucleolar protein B23/nucleophosmin and inhibits ribosome biogenesis. Huang N, et al. J Biol Chem, 2005 Feb 18. PMID 15596447
  4. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. Xiong X, et al. Elife, 2014 Aug 21. PMID 25144937, Free PMC Article
  5. p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis. Fessing MY, et al. J Cell Biol, 2011 Sep 19. PMID 21930775, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in translation at postsynapse EXP
Inferred from Experiment
more info
 PubMed 
involved_in translation at postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse EXP
Inferred from Experiment
more info
 PubMed 
involved_in translation at presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in ribosome EXP
Inferred from Experiment
more info
 PubMed 
is_active_in ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
small ribosomal subunit protein eS27
Names
40S ribosomal protein S27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027015.4 → NP_081291.1  small ribosomal subunit protein eS27

    See identical proteins and their annotated locations for NP_081291.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AK166551, BC055693
    Consensus CDS
    CCDS50970.1
    UniProtKB/Swiss-Prot
    Q3TLE3, Q6ZWU9
    UniProtKB/TrEMBL
    A0A0G2JDW7
    Related
    ENSMUSP00000132102.3, ENSMUST00000170122.4
    Conserved Domains (1) summary
    PLN00209
    Location:6 → 82
    PLN00209; ribosomal protein S27; Provisional

RNA

  1. NR_033727.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA036204, AC119825, AI851912, AK166551, BC055693
    Related
    ENSMUST00000200305.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    90119974..90120955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZWU9.3 GenPept UniProtKB/Swiss-Prot:Q6ZWU9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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