dock1 dedicator of cytokinesis 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dock1provided by ZNC
Official Full Name: dedicator of cytokinesis 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-080108-5
See related: Ensembl:ENSDARG00000099093 AllianceGenome:ZFIN:ZDB-GENE-080108-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within myelination in peripheral nervous system and myoblast fusion. Predicted to be located in cytoplasm and membrane. Predicted to be integral component of membrane. Orthologous to human DOCK1 (dedicator of cytokinesis 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (44362681..44821797, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (43454781..43658265, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_008805362.1 (3058..36201, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrated that Mutations in dock1 disrupt early Schwann cell development.
Title: Mutations in dock1 disrupt early Schwann cell development.
A novel signaling cascade is identified in which ELMO1/DOCK180 regulates vasculature formation in zebrafish.
Title: The Rac1 regulator ELMO1 controls vascular morphogenesis in zebrafish.
The fusion of embryonic fast-twitch myoblasts requires the activities of Dock1 and the closely related Dock5 protein.
Title: A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion.

Submit: New GeneRIF Correction

General gene information

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Markers

G40057 (e-PCR)
- UniSTS:52250

G39588 (e-PCR)
- UniSTS:10963

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myelination in peripheral nervous system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast fusion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dedicator of cytokinesis protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110011.1 → NP_001103481.1 dedicator of cytokinesis protein 1

See identical proteins and their annotated locations for NP_001103481.1

Status: PROVISIONAL

Source sequence(s)

AM888370

UniProtKB/TrEMBL

A8E1V6

Related

ENSDARP00000137898.2, ENSDART00000162888.2

Conserved Domains (4) summary

cd08694
Location:423 → 617

C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins

cd12051
Location:12 → 67

SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5

pfam16172
Location:71 → 415

DOCK_N; DOCK N-terminus

cl06123
Location:1210 → 1609

DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins