fdft1 farnesyl-diphosphate farnesyltransferase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fdft1provided by ZNC
Official Full Name: farnesyl-diphosphate farnesyltransferase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-081104-242
See related: Ensembl:ENSDARG00000101062 AllianceGenome:ZFIN:ZDB-GENE-081104-242
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch73-107c13.2
Summary: Predicted to enable farnesyl-diphosphate farnesyltransferase activity and squalene synthase activity. Predicted to be involved in cholesterol biosynthetic process and farnesyl diphosphate metabolic process. Predicted to act upstream of or within lipid biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human FDFT1 (farnesyl-diphosphate farnesyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (52907382..52939329, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (53101980..53133912, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables farnesyl-diphosphate farnesyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables farnesyl-diphosphate farnesyltransferase activity	IEA Inferred from Electronic Annotation more info
enables farnesyltranstransferase activity	IEA Inferred from Electronic Annotation more info
enables squalene synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables squalene synthase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring alkyl or aryl (other than methyl) groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in farnesyl diphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: squalene synthase

Names: squalene synthetase

NP_001189454.1

EC 2.5.1.21

XP_021324186.1

EC 2.5.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001202525.1 → NP_001189454.1 squalene synthase

Status: PROVISIONAL

Source sequence(s)

CU207296

UniProtKB/TrEMBL

A0A0R4IVV5, A0A8M1P1T1

Related

ENSDARP00000141194.1, ENSDART00000166508.2

Conserved Domains (1) summary

cl00210
Location:40 → 368

Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

52907382..52939329 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468511.1 → XP_021324186.1 squalene synthase isoform X1

UniProtKB/TrEMBL

A0A8M9PPK1

Conserved Domains (1) summary

cl00210
Location:69 → 397

Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1