PAK5 p21 (RAC1) activated kinase 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PAK5provided by HGNC
Official Full Name: p21 (RAC1) activated kinase 5provided by HGNC
Primary source: HGNC:HGNC:15916
See related: Ensembl:ENSG00000101349 MIM:608038; AllianceGenome:HGNC:15916
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PAK7
Summary: The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 4.1), adrenal (RPKM 1.0) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 20p12.2

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (9537370..9839076, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (9580273..9881978, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (9518017..9819724, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAK5 potentiates slug transactivation of N-cadherin to facilitate metastasis of renal cell carcinoma.
Title: PAK5 potentiates slug transactivation of N-cadherin to facilitate metastasis of renal cell carcinoma.
PAK5 is a potential target in myelodysplastic syndrome through interacting with LMO2 and GATA1.
Title: PAK5 is a potential target in myelodysplastic syndrome through interacting with LMO2 and GATA1.
The Predictive Value of PAK7 Mutation for Immune Checkpoint Inhibitors Therapy in Non-Small Cell Cancer.
Title: The Predictive Value of PAK7 Mutation for Immune Checkpoint Inhibitors Therapy in Non-Small Cell Cancer.
Inhibiting p21-activated kinase (PAK7) enhances radiosensitivity in hepatocellular carcinoma.
Title: Inhibiting p21-activated kinase (PAK7) enhances radiosensitivity in hepatocellular carcinoma.
P21-activated kinase 5 potentiates the chemoresistant phenotype of liver cancer.
Title: P21-activated kinase 5 potentiates the chemoresistant phenotype of liver cancer.
PAK5 promotes RNA helicase DDX5 sumoylation and miRNA-10b processing in a kinase-dependent manner in breast cancer.
Title: PAK5 promotes RNA helicase DDX5 sumoylation and miRNA-10b processing in a kinase-dependent manner in breast cancer.
PAK5-stabilized Smuc confers renal cell carcinoma metastasis.
Title: PAK5-stabilized Smuc confers renal cell carcinoma metastasis.
MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating beta-catenin signaling in hyperlipidemia.
Title: MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating β-catenin signaling in hyperlipidemia.
Prognostic significance of PAK family kinases in acute myeloid leukemia.
Title: Prognostic significance of PAK family kinases in acute myeloid leukemia.
PAK5 facilitates the proliferation, invasion and migration in colorectal cancer cells.
Title: PAK5 facilitates the proliferation, invasion and migration in colorectal cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D20S503 (e-PCR)
- UniSTS:150304

G18107 (e-PCR)
- UniSTS:80161

PAK7_1448 (e-PCR)
- UniSTS:277553

AL034531 (e-PCR)
- UniSTS:94281

WI-15350 (e-PCR)
- UniSTS:7266

D20S958 (e-PCR)
- UniSTS:28056

G59174 (e-PCR)
- UniSTS:136348

RH121007 (e-PCR)
- UniSTS:134059

G65503 (e-PCR)
- UniSTS:166583

RH12132 (e-PCR)
- UniSTS:22204

Z94709 (e-PCR)
- UniSTS:80620

D20S723 (e-PCR)
- UniSTS:61938

RH25698 (e-PCR)
- UniSTS:92158

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in cell migration	TAS Traceable Author Statement more info	PubMed
involved_in cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in learning	IEA Inferred from Electronic Annotation more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in memory	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell growth	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase PAK 5

Names: PAK-5; PAK-7; p21 (RAC1) activated kinase 7; p21 protein (Cdc42/Rac)-activated kinase 7; p21(CDKN1A)-activated kinase 7; p21-activated kinase 5; p21-activated kinase 7; p21CDKN1A-activated kinase 7; protein kinase PAK5; serine/threonine-protein kinase PAK 7; serine/threonine-protein kinase PAK7

NP_065074.1

EC 2.7.11.1

NP_817127.1

EC 2.7.11.1

XP_016883449.1

EC 2.7.11.1

XP_016883450.1

EC 2.7.11.1

XP_016883451.1

EC 2.7.11.1

XP_016883453.1

EC 2.7.11.1

XP_016883454.1

EC 2.7.11.1

XP_054179701.1

EC 2.7.11.1

XP_054179702.1

EC 2.7.11.1

XP_054179703.1

EC 2.7.11.1

XP_054179704.1

EC 2.7.11.1

XP_054179705.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020341.5 → NP_065074.1 serine/threonine-protein kinase PAK 5

See identical proteins and their annotated locations for NP_065074.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. This variant and variant 2 encode the same protein.

Source sequence(s)

AB033090, AB040812, AK315820, AL031652, AL034427

Consensus CDS

CCDS13107.1

UniProtKB/Swiss-Prot

A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6

UniProtKB/TrEMBL

B0AZM9

Related

ENSP00000367686.3, ENST00000378429.3

Conserved Domains (2) summary

cd06658
Location:426 → 717

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
NM_177990.4 → NP_817127.1 serine/threonine-protein kinase PAK 5

See identical proteins and their annotated locations for NP_817127.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an internal 5' UTR exon, as compared to variant 1. Both variants encode the same protein.

Source sequence(s)

AB040812, AK307926, AK315820, AL031652, AL034427

Consensus CDS

CCDS13107.1

UniProtKB/Swiss-Prot

A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6

UniProtKB/TrEMBL

B0AZM9

Related

ENSP00000322957.5, ENST00000353224.10

Conserved Domains (2) summary

cd06658
Location:426 → 717

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

9537370..9839076 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017027960.2 → XP_016883449.1 serine/threonine-protein kinase PAK 5 isoform X1

UniProtKB/Swiss-Prot

A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6

UniProtKB/TrEMBL

B0AZM9

Conserved Domains (2) summary

cd06658
Location:426 → 717

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
XM_017027961.2 → XP_016883450.1 serine/threonine-protein kinase PAK 5 isoform X1

UniProtKB/Swiss-Prot

A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6

UniProtKB/TrEMBL

B0AZM9

Conserved Domains (2) summary

cd06658
Location:426 → 717

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
XM_017027962.2 → XP_016883451.1 serine/threonine-protein kinase PAK 5 isoform X1

UniProtKB/Swiss-Prot

A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6

UniProtKB/TrEMBL

B0AZM9

Conserved Domains (2) summary

cd06658
Location:426 → 717

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
XM_017027964.2 → XP_016883453.1 serine/threonine-protein kinase PAK 5 isoform X1

UniProtKB/Swiss-Prot

A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6

UniProtKB/TrEMBL

B0AZM9

Conserved Domains (2) summary

cd06658
Location:426 → 717

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
XM_017027965.2 → XP_016883454.1 serine/threonine-protein kinase PAK 5 isoform X1

UniProtKB/Swiss-Prot

A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6

UniProtKB/TrEMBL

B0AZM9

Conserved Domains (2) summary

cd06658
Location:426 → 717

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...