abcb11b ATP-binding cassette, sub-family B (MDR/TAP), member 11b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: abcb11bprovided by ZNC
Official Full Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050517-14
See related: Ensembl:ENSDARG00000070078 AllianceGenome:ZFIN:ZDB-GENE-050517-14
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: bsep
Summary: Predicted to enable ABC-type bile acid transporter activity and canalicular bile acid transmembrane transporter activity. Acts upstream of or within bile acid secretion. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in liver. Used to study progressive familial intrahepatic cholestasis 2. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (13223611..13270034)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (13165971..13212375)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables ABC-type bile acid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables canalicular bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bile acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canalicular bile acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain