itga1 integrin, alpha 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: itga1provided by ZNC
Official Full Name: integrin, alpha 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-091118-115
See related: Ensembl:ENSDARG00000074316 AllianceGenome:ZFIN:ZDB-GENE-091118-115
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-27b3.5
Summary: Predicted to enable metal ion binding activity. Predicted to act upstream of or within cell adhesion and integrin-mediated signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of integrin complex. Orthologous to human ITGA1 (integrin subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (8730940..8841847)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (8897358..9008102)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin alpha-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

8730940..8841847

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479255.1 → XP_021334930.1 integrin alpha-1 isoform X1

UniProtKB/TrEMBL

A0A8M9QKV2

Related

ENSDARP00000114988.1, ENSDART00000145596.3

Conserved Domains (3) summary

smart00191
Location:565 → 618

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:661 → 1070

Integrin_alpha2; Integrin alpha

cl00057
Location:167 → 348

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_021479256.1 → XP_021334931.1 integrin alpha-1 isoform X2

UniProtKB/TrEMBL

A0A8M9QGT0

Conserved Domains (3) summary

smart00191
Location:459 → 512

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:555 → 964

Integrin_alpha2; Integrin alpha

cl00057
Location:61 → 242

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394768.1 Reference GRCz11 ALT_DRER_TU_1

Range

69045..187162

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_694393.7 → XP_699485.5 integrin alpha-1 isoform X1

UniProtKB/TrEMBL

A0A8N7UVP6

Conserved Domains (3) summary

smart00191
Location:565 → 618

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:661 → 1070

Integrin_alpha2; Integrin alpha

cl00057
Location:167 → 348

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...