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pfkla phosphofructokinase, liver a [ Danio rerio (zebrafish) ]

Gene ID: 570106, updated on 27-Mar-2024

Summary

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Official Symbol
pfklaprovided by ZNC
Official Full Name
phosphofructokinase, liver aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-121207-1
See related
Ensembl:ENSDARG00000060504 AllianceGenome:ZFIN:ZDB-GENE-121207-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable 6-phosphofructokinase activity; ATP binding activity; and metal ion binding activity. Predicted to act upstream of or within fructose 6-phosphate metabolic process and glycolytic process. Predicted to be located in cytoplasm. Is expressed in liver. Orthologous to human PFKL (phosphofructokinase, liver type). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 9
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (52627323..52678298, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (53087649..53138777, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110440054 Neighboring gene transmembrane protein 169b Neighboring gene si:ch211-45c16.2 Neighboring gene uncharacterized LOC101884915 Neighboring gene transient receptor potential cation channel, subfamily M, member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations. Qi H, et al. Adv Sci (Weinh), 2021 Sep. PMID 34278746, Free PMC Article
  2. High-carbohydrate diet promotes the adaptation to acute hypoxia in zebrafish. Ma Q, et al. Fish Physiol Biochem, 2020 Apr. PMID 31820205
  3. Phoenixin-20 suppresses food intake, modulates glucoregulatory enzymes, and enhances glycolysis in zebrafish. Rajeswari JJ, et al. Am J Physiol Regul Integr Comp Physiol, 2020 May 1. PMID 32208925, Free PMC Article
  4. Mutation of spexin2 promotes feeding, somatic growth, adiposity, and insulin resistance in zebrafish. Zhao T, et al. Am J Physiol Regul Integr Comp Physiol, 2022 May 1. PMID 35293264
  5. Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish. Blanco AM, et al. Sci Rep, 2020 Jul 1. PMID 32612127, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 6-phosphofructokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fructose 6-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycolytic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP-dependent 6-phosphofructokinase, liver type
Names
pfkl

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    52627323..52678298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_693543.8 → XP_698635.3  ATP-dependent 6-phosphofructokinase, liver type

    UniProtKB/TrEMBL
    A0A8N7TBX7, E7F9M6
    Related
    ENSDARP00000079719.4, ENSDART00000085284.7
    Conserved Domains (2) summary
    cd00764
    Location:13 → 773
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
    TIGR02478
    Location:16 → 754
    6PF1K_euk; 6-phosphofructokinase, eukaryotic type
Nucleotide Protein Strain
Heading Accession and Version

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