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KIF15 kinesin family member 15 [ Homo sapiens (human) ]

Gene ID: 56992, updated on 7-Apr-2024

Summary

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Official Symbol
KIF15provided by HGNC
Official Full Name
kinesin family member 15provided by HGNC
Primary source
HGNC:HGNC:17273
See related
Ensembl:ENSG00000163808 MIM:617569; AllianceGenome:HGNC:17273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLP2; HKLP2; KNSL7; BRDCS2; NY-BR-62
Summary
Predicted to enable microtubule binding activity and microtubule motor activity. Predicted to be involved in microtubule-based movement. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 8.0), bone marrow (RPKM 4.1) and 13 other tissues See more
Orthologs
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Genomic context

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Location:
3p21.31
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44761794..44868687)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44777475..44868975)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44803286..44894748)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 501 Neighboring gene KIAA1143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44801624-44802266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19771 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 77 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19772 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14273 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14274 Neighboring gene microRNA 564 Neighboring gene transmembrane protein 42 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:44925386-44926063 Neighboring gene Sharpr-MPRA regulatory region 3821 Neighboring gene peptidylprolyl isomerase A pseudogene 18 Neighboring gene transglutaminase 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44940040-44940581

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KIF15 is essential for USP10-mediated PGK1 deubiquitination during the glycolysis of pancreatic cancer. Quan G, et al. Cell Death Dis, 2023 Feb 17. PMID 36807568, Free PMC Article
  2. Dynamic regulation of KIF15 phosphorylation and acetylation promotes focal adhesions disassembly in pancreatic cancer. He Z, et al. Cell Death Dis, 2022 Oct 25. PMID 36280663, Free PMC Article
  3. Rare and Common Variants in KIF15 Contribute to Genetic Risk of Idiopathic Pulmonary Fibrosis. Zhang D, et al. Am J Respir Crit Care Med, 2022 Jul 1. PMID 35417304, Free PMC Article
  4. Downregulation of KIF15 inhibits the tumorigenesis of non-small-cell lung cancer via inactivating Raf/MEK/ERK signaling. Luo Y, et al. Histol Histopathol, 2022 Mar. PMID 34908156
  5. KIF15 knockdown suppresses gallbladder cancer development. Wang J, et al. Eur J Cell Biol, 2021 Sep-Nov. PMID 34781077

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIF15 missense variant is associated with the early onset of idiopathic pulmonary fibrosis.
    Title: KIF15 missense variant is associated with the early onset of idiopathic pulmonary fibrosis.
  2. KIF15 knockdown inhibits the development of endometrial cancer by suppressing epithelial-mesenchymal transition and stemness through Wnt/beta-catenin signaling.
    Title: KIF15 knockdown inhibits the development of endometrial cancer by suppressing epithelial-mesenchymal transition and stemness through Wnt/β-catenin signaling.
  3. KIF15 is essential for USP10-mediated PGK1 deubiquitination during the glycolysis of pancreatic cancer.
    Title: KIF15 is essential for USP10-mediated PGK1 deubiquitination during the glycolysis of pancreatic cancer.
  4. Dynamic regulation of KIF15 phosphorylation and acetylation promotes focal adhesions disassembly in pancreatic cancer.
    Title: Dynamic regulation of KIF15 phosphorylation and acetylation promotes focal adhesions disassembly in pancreatic cancer.
  5. PSMD12 promotes the activation of the MEK-ERK pathway by upregulating KIF15 to promote the malignant progression of liver cancer.
    Title: PSMD12 promotes the activation of the MEK-ERK pathway by upregulating KIF15 to promote the malignant progression of liver cancer.
  6. Rare and Common Variants in KIF15 Contribute to Genetic Risk of Idiopathic Pulmonary Fibrosis.
    Title: Rare and Common Variants in KIF15 Contribute to Genetic Risk of Idiopathic Pulmonary Fibrosis.
  7. Downregulation of KIF15 inhibits the tumorigenesis of non-small-cell lung cancer via inactivating Raf/MEK/ERK signaling.
    Title: Downregulation of KIF15 inhibits the tumorigenesis of non-small-cell lung cancer via inactivating Raf/MEK/ERK signaling.
  8. K-fiber bundles in the mitotic spindle are mechanically reinforced by Kif15.
    Title: K-fiber bundles in the mitotic spindle are mechanically reinforced by Kif15.
  9. KIF15 knockdown suppresses gallbladder cancer development.
    Title: KIF15 knockdown suppresses gallbladder cancer development.
  10. Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.
    Title: Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Braddock-carey syndrome 2
MedGen: C5774189 OMIM: 619981 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25667

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity TAS
Traceable Author Statement
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of plus-end kinesin complex TAS
Traceable Author Statement
more info
 PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF15
Names
kinesin-like 7
kinesin-like protein 2
kinesin-like protein 7
serologically defined breast cancer antigen NY-BR-62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020242.3 → NP_064627.1  kinesin-like protein KIF15

    See identical proteins and their annotated locations for NP_064627.1

    Status: VALIDATED

    Source sequence(s)
    AB035898, AK307674, AL832908, DR005852
    Consensus CDS
    CCDS33744.1
    UniProtKB/Swiss-Prot
    Q17RV9, Q69YL6, Q96JX7, Q9H280, Q9NS87
    Related
    ENSP00000324020.4, ENST00000326047.9
    Conserved Domains (5) summary
    smart00129
    Location:26 → 370
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1196
    Location:490 → 1331
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01373
    Location:25 → 373
    KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup
    pfam12711
    Location:463 → 551
    Kinesin-relat_1; Kinesin motor
    pfam15908
    Location:1281 → 1376
    HMMR_C; Hyaluronan mediated motility receptor C-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    44761794..44868687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006884.3 → XP_016862373.1  kinesin-like protein KIF15 isoform X1

  2. XM_011533964.4 → XP_011532266.1  kinesin-like protein KIF15 isoform X3

    See identical proteins and their annotated locations for XP_011532266.1

    Conserved Domains (5) summary
    smart00129
    Location:26 → 370
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1196
    Location:490 → 1265
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01373
    Location:25 → 373
    KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup
    pfam12711
    Location:463 → 551
    Kinesin-relat_1; Kinesin motor
    pfam15908
    Location:1215 → 1310
    HMMR_C; Hyaluronan mediated motility receptor C-terminal

  3. XM_017006885.3 → XP_016862374.1  kinesin-like protein KIF15 isoform X2

  4. XM_017006887.3 → XP_016862376.1  kinesin-like protein KIF15 isoform X4

  5. XM_017006889.3 → XP_016862378.1  kinesin-like protein KIF15 isoform X8

  6. XM_047448602.1 → XP_047304558.1  kinesin-like protein KIF15 isoform X6

  7. XM_047448603.1 → XP_047304559.1  kinesin-like protein KIF15 isoform X7

  8. XM_047448601.1 → XP_047304557.1  kinesin-like protein KIF15 isoform X5

  9. XM_017006890.2 → XP_016862379.1  kinesin-like protein KIF15 isoform X9

  10. XM_006713264.4 → XP_006713327.1  kinesin-like protein KIF15 isoform X10

    See identical proteins and their annotated locations for XP_006713327.1

    UniProtKB/TrEMBL
    C9JKA9
    Related
    ENSP00000389982.1, ENST00000425755.5
    Conserved Domains (3) summary
    COG1196
    Location:125 → 901
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12711
    Location:98 → 186
    Kinesin-relat_1; Kinesin motor
    pfam15908
    Location:916 → 1011
    HMMR_C; Hyaluronan mediated motility receptor C-terminal

RNA

  1. XR_007095708.1 RNA Sequence

    Related
    ENST00000438321.5

  2. XR_007095709.1 RNA Sequence

  3. XR_007095710.1 RNA Sequence

  4. XR_001740214.2 RNA Sequence

  5. XR_001740215.2 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p14 PATCHES

    Range
    287144..378606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331546.1 → XP_054187521.1  kinesin-like protein KIF15 isoform X1

  2. XM_054331548.1 → XP_054187523.1  kinesin-like protein KIF15 isoform X3

  3. XM_054331547.1 → XP_054187522.1  kinesin-like protein KIF15 isoform X2

  4. XM_054331549.1 → XP_054187524.1  kinesin-like protein KIF15 isoform X4

  5. XM_054331551.1 → XP_054187526.1  kinesin-like protein KIF15 isoform X6

  6. XM_054331552.1 → XP_054187527.1  kinesin-like protein KIF15 isoform X7

  7. XM_054331553.1 → XP_054187528.1  kinesin-like protein KIF15 isoform X8

  8. XM_054331550.1 → XP_054187525.1  kinesin-like protein KIF15 isoform X5

  9. XM_054331554.1 → XP_054187529.1  kinesin-like protein KIF15 isoform X9

  10. XM_054331555.1 → XP_054187530.1  kinesin-like protein KIF15 isoform X10

    UniProtKB/TrEMBL
    C9JKA9

RNA

  1. XR_008485721.1 RNA Sequence

  2. XR_008485723.1 RNA Sequence

  3. XR_008485722.1 RNA Sequence

  4. XR_008485724.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    44777475..44868975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347303.1 → XP_054203278.1  kinesin-like protein KIF15 isoform X1

  2. XM_054347305.1 → XP_054203280.1  kinesin-like protein KIF15 isoform X3

  3. XM_054347304.1 → XP_054203279.1  kinesin-like protein KIF15 isoform X2

  4. XM_054347306.1 → XP_054203281.1  kinesin-like protein KIF15 isoform X4

  5. XM_054347308.1 → XP_054203283.1  kinesin-like protein KIF15 isoform X6

  6. XM_054347309.1 → XP_054203284.1  kinesin-like protein KIF15 isoform X7

  7. XM_054347310.1 → XP_054203285.1  kinesin-like protein KIF15 isoform X8

  8. XM_054347307.1 → XP_054203282.1  kinesin-like protein KIF15 isoform X5

  9. XM_054347311.1 → XP_054203286.1  kinesin-like protein KIF15 isoform X9

  10. XM_054347312.1 → XP_054203287.1  kinesin-like protein KIF15 isoform X10

RNA

  1. XR_008486751.1 RNA Sequence

  2. XR_008486753.1 RNA Sequence

  3. XR_008486752.1 RNA Sequence

  4. XR_008486754.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NS87.1 GenPept UniProtKB/Swiss-Prot:Q9NS87

Gene LinkOut

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